Circulating oxidized LDL levels, current smoking and obesity in postmenopausal women

Kassi, Eva; Dalamaga, Maria; Faviou, E.; Hroussalas, G.; Kazanis, K.; Nounopoulos, Ch; Dionyssiou-Asteriou, Amalia

doi:10.1016/j.atherosclerosis.2008.11.006

Cited by 44 publications

(27 citation statements)

References 39 publications

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“…Cardiovascular disease represents one of the leading causes of death in post-menopausal women (van der Schouw, 2009). Menopause is associated with the increase of the visceral adipose tissue (Deibert et al, 2007), the increase of the oxidative stress (Kassi et al, 2009), and alterations in the metabolic and endocrine status that could be related to the development of the metabolic syndrome, atherosclerosis, and cardiovascular disease (Lobo, 2008;Gaspard, 2009). The existence of biomarkers upstream from markers of myocardial necrosis that could provide an earlier assessment of overall patient risk would prevent a number of cardiovascular death (Apple et al, 2005).…”

Section: Human Serum Albumin and Ischemiamentioning

confidence: 99%

Human serum albumin: From bench to bedside

Fanali

Masi

Trezza

et al. 2012

Molecular Aspects of Medicine

1,515

1,452

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Section: Human Serum Albumin and Ischemiamentioning

confidence: 99%

Human serum albumin: From bench to bedside

Fanali

Masi

Trezza

et al. 2012

Molecular Aspects of Medicine

1,515

1,452

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“…atherosclerosis; insulin resistance CHRONIC ALTERATIONS IN LIPID PROFILE have been associated with high circulating levels and resistance to insulin, a condition favoring atherogenesis and acute cardiovascular events (7,9,20). Importantly, the exposure to high plasma levels of free fatty acids (FFAs) might be particularly related to hyperisulinemia (20).…”

mentioning

confidence: 99%

Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome

Montecucco¹,

Bertolotto

Vuilleumier

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

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Metabolic syndrome is a proatherosclerotic condition clustering cardiovascular risk factors, including glucose and lipid profile alterations. The pathophysiological mechanisms favoring atherosclerotic inflammation in the metabolic syndrome remain elusive. Here, we investigated the potential role of the antilipolytic drug acipimox on neutrophil- and monocyte-mediated inflammation in the metabolic syndrome. Acipimox (500 mg) was orally administered to metabolic syndrome patients (n = 11) or healthy controls (n = 8). Serum and plasma was collected before acipimox administration (time 0) as well as 2-5 h afterward to assess metabolic and hematologic parameters. In vitro, the effects of the incubation with metabolic syndrome serum were assessed on human neutrophil and monocyte migration toward the proatherosclerotic chemokine CCL3. Two to five hours after acipimox administration, a significant reduction in circulating levels of insulin and nonesterified fatty acid (NEFA) was shown in metabolic syndrome patients. At time 0 and 2 h after acipimox administration, metabolic syndrome serum increased neutrophil migration to CCL3 compared with healthy controls. No effect was shown in human monocytes. At these time points, serum-induced neutrophil migration positively correlated with serum levels of insulin and NEFA. Metabolic syndrome serum or recombinant insulin did not upregulate CCR5 expression on neutrophil surface membrane, but it increased intracellular JNK1/2 phosphorylation. Insulin immunodepletion blocked serum-induced neutrophil migration and associated JNK1/2 phosphorylation. Although mRNA expression of acipimox receptor (GPR109) was shown in human neutrophils, 5-500 μM acipimox did not affect insulin-induced neutrophil migration. In conclusion, results suggest that acipimox inhibited neutrophil proatherosclerotic functions in the metabolic syndrome through the reduction in circulating levels of insulin

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“…It is known that smokers have elevated levels of oxLDL [33], [34], as cigarette smoke contains large amounts of oxidants and free radicals, which promote oxidative modification of lipids and proteins [35], [36]. Moreover, Hovolet and coworkers demonstrated that current smoking presents one of the strongest risk factor correlates of oxLDL [37].…”

Section: Discussionmentioning

confidence: 99%

“…The two week period of rehabilitation is probably too short to annotate the lack of improvement of certain inflammatory and oxidative markers in smokers only to higher compliance of nonsmokers. It might be that smokers, due to already known higher baseline level of oxidative stress and inflammation [33], [34], [39], [40], need longer periods of time than nonsmokers to reach the level, where the desired effects become clinically shown. Since physical activity and diet may have synergistic effects, it is possible that smokers, who usually present with lower exercise capacity, were therefore less able to exert the beneficial effects of coupled diet and exercise program.…”

Section: Discussionmentioning

confidence: 99%

The effect of cardioprotective diet rich with natural antioxidants on chronic inflammation and oxidized LDL during cardiac rehabilitation in patients after acute myocardial infarction

Mlakar

Salobir

Čobo³

et al. 2015

IJC Heart & Vasculature

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BackgroundChronic inflammation, the fundamental pathogenetic process of atherosclerosis, can be modified by pharmacological and non-pharmacological measures as a part of secondary prevention after acute myocardial infarction (AMI). The aim of our study was to determine the effect of diet, rich with natural antioxidants, added to physical activity (as a part of cardiac rehabilitation (CR) program) on inflammatory markers and ox-LDL, a marker of oxidative stress, closely involved in the process of chronic inflammation.Methods41 male patients after AMI undergoing CR were divided into a diet group (supervised cardioprotective diet throughout the CR), and control group (CR without diet). We measured hsCRP, leucocytes, neutrophils, IL-6, oxLDL, exercise capacity and classic risk factors before and after CR program.ResultsPatients from the diet group presented with a significant decline in classic risk factors (BMI, waist circumference, waist to hip ratio, systolic blood pressure, heart rate, blood glucose, total cholesterol, LDL, TAG) and inflammatory markers (hsCRP, leucocytes, neutrophils) compared to control group. Furthermore, when studying nonsmokers, we observed significant decline of oxLDL in the diet group.ConclusionsThe addition of cardioprotective diet, rich with natural antioxidants, to physical activity as a part of a CR program, positively modifies not just classic risk factors and exercise capacity, but also diminishes chronic inflammation markers. These effects, and oxLDL decline were most prominent in nonsmoking patients.

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Circulating oxidized LDL levels, current smoking and obesity in postmenopausal women

Cited by 44 publications

References 39 publications

Human serum albumin: From bench to bedside

Human serum albumin: From bench to bedside

Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome

The effect of cardioprotective diet rich with natural antioxidants on chronic inflammation and oxidized LDL during cardiac rehabilitation in patients after acute myocardial infarction

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