Circulating profiling reveals the effect of a polyunsaturated fatty acid-enriched diet on common microRNAs

Ortega, Francisco; Cardona-Alvarado, Monica I; Mercader, Josep M.; Moreno-Navarrete, José María; Moreno, María; Sabater, Mònica; Fuentes-Batllevell, Núria; Ramı́rez-Chávez, Enrique; Ricart, Wifredo; Molina‐Torres, Jorge; Pérez-Luque, Elva; Fernández-Real, José Manuel

doi:10.1016/j.jnutbio.2015.05.001

Cited by 86 publications

(94 citation statements)

References 41 publications

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“…However, miRNAs in circulation and skeletal muscle have poorly understood in farm animals thus far. Nevertheless, a polyunsaturated fatty acids (PUFAs)-enriched diet might have the potential to alter the expression of c-miRNAs linked to changes in dietary fatty acids (as inferred from plasma fatty acid concentration) [33]. In the present study, we focused on the effects of feeding conditions on c-miRNAs and skeletal muscle miRNAs as well as on muscle target genes in JB cattle, whose beef has high marbling potential, to understand not only the implications of feeding diet and grazing on the expression of the set of miRNAs and their target genes in skeletal muscles, but also the associations between altered muscle gene expression and c-miRNAs.…”

Section: Discussionmentioning

confidence: 99%

Differences in Circulating microRNAs between Grazing and Grain-Fed Wagyu Cattle Are Associated with Altered Expression of Intramuscular microRNA, the Potential Target PTEN, and Lipogenic Genes

et al. 2016

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We aimed to understand the roles of miRNAs in the muscle tissue maturation and those of circulating microRNAs (c-miRNAs) in beef production of Japanese Black (JB) cattle (Wagyu), a breed with genetically background of superior intermuscular fat depot, by comparing different feeding conditions (indoor grain-feeding vs. grazing on pasture). The cattle at 18 months old were assigned to pasture feeding or conventional indoor grain feeding conditions for 5 months. Microarray analysis of c-miRNAs from the plasma extracellular vesicles led to the detection of a total of 202 bovine miRNAs in the plasma, including 15 miRNAs that differed between the feeding conditions. Validation of the microarray results by qPCR showed that the circulating miR-10b level in the grazing cattle was upregulated compared to that of the grain-fed cattle. In contrast, the levels of miR-17-5p, miR-19b, miR-29b, miR-30b-5p, miR-98, miR-142-5p, miR-301a, miR-374b, miR-425-5p, and miR-652 were lower in the grazing cattle than in the grain-fed cattle. Bioinformatic analysis indicated that the predicted target genes of those c-miRNAs were enriched in gene ontology terms associated with blood vessel morphogenesis, plasma membrane, focal adhesion, endocytosis, collagen, ECM-receptor interaction, and phosphorylation. In the grazing cattle, the elevation of miR-10b expression in the plasma was coincident with its elevation in the longissimus lumborum (LL) muscle. Expression of bovine-specific miR-2478, the most plasma-enriched miRNA, tended to be also upregulated in the muscle but not in the plasma. Furthermore, grazing caused the downregulated mRNA expression of predicted miR-10b and/or miR-2478 target genes, such as DNAJB2, PTEN, and SCD1. Thus, the feeding system used for JB cattle affected the c-miRNAs that could be indicators of grain feeding. Among these, miR-10b expression was especially associated with feeding-induced changes and with the expression of the potential target genes responsible for glucose homeostasis and intramuscular fat depot in the LL muscle of JB cattle.

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Section: Discussionmentioning

confidence: 99%

Differences in Circulating microRNAs between Grazing and Grain-Fed Wagyu Cattle Are Associated with Altered Expression of Intramuscular microRNA, the Potential Target PTEN, and Lipogenic Genes

et al. 2016

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“…The underlying mechanisms contributing to these inconsistent results are incompletely understood. 161 …”

Section: Discussionmentioning

confidence: 99%

Nutrition and Diet Factors in Type 2 Diabetes

2018

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“…miR-181a also directly inhibits SIRT1 , resulting in decreased insulin sensitivity [120]. Interestingly, circulating levels of miR-130b increase after an intervention with polyunsaturated fatty acids in women [121]. Another study showed that miR-34 is upregulated in age-related macular degeneration [122].…”

Section: Miragings: What and Which Are They? How Can They Be Modulmentioning

confidence: 99%

“…Interestingly, miR-19b was found to be downregulated in octogenarians, while centenarians and young people conserved the same level of this microRNA [111]. miR-19b could also be a biomarker of polyunsaturated fatty acids intake, as its circulating levels increased in women after eight weeks of a normocaloric diet enriched in these fatty acids [121]. In atherosclerosis, these microRNAs could induce endothelial cell dysfunction through the downregulation of PGC-1α [144].…”

Section: Miragings: What and Which Are They? How Can They Be Modulmentioning

confidence: 99%

“…In this same work, other microRNAs associated with age that regulate the PI3K/AKT pathway and SIRT1, increased in old monkeys submitted to a CR intervention [149]. Apart from these microRNAs, it must be highlighted the role of miR-221 that is downregulated by CR [149] and polyunsaturated fatty acids [121]. In murine models, a group of miRNAs (miR-425, miR-196, miR-155, miR-150, miR-351, miR-16, let-7, miR-34, and miR-138) were differentially expressed between the control and CR groups [164].…”

Section: Miragings: What and Which Are They? How Can They Be Modulmentioning

confidence: 99%

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NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging

Micó

Berninches

Tapia

et al. 2017

IJMS

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Current sociodemographic predictions point to a demographic shift in developed and developing countries that will result in an unprecedented increase of the elderly population. This will be accompanied by an increase in age-related conditions that will strongly impair human health and quality of life. For this reason, aging is a major concern worldwide. Healthy aging depends on a combination of individual genetic factors and external environmental factors. Diet has been proved to be a powerful tool to modulate aging and caloric restriction has emerged as a valuable intervention in this regard. However, many questions about how a controlled caloric restriction intervention affects aging-related processes are still unanswered. Nutrient sensing pathways become deregulated with age and lose effectiveness with age. These pathways are a link between diet and aging. Thus, fully understanding this link is a mandatory step before bringing caloric restriction into practice. MicroRNAs have emerged as important regulators of cellular functions and can be modified by diet. Some microRNAs target genes encoding proteins and enzymes belonging to the nutrient sensing pathways and, therefore, may play key roles in the modulation of the aging process. In this review, we aimed to show the relationship between diet, nutrient sensing pathways and microRNAs in the context of aging.

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Circulating profiling reveals the effect of a polyunsaturated fatty acid-enriched diet on common microRNAs

Cited by 86 publications

References 41 publications

Differences in Circulating microRNAs between Grazing and Grain-Fed Wagyu Cattle Are Associated with Altered Expression of Intramuscular microRNA, the Potential Target PTEN, and Lipogenic Genes

Differences in Circulating microRNAs between Grazing and Grain-Fed Wagyu Cattle Are Associated with Altered Expression of Intramuscular microRNA, the Potential Target PTEN, and Lipogenic Genes

Nutrition and Diet Factors in Type 2 Diabetes

NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging

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