Circulating sclerostin levels in relation to nutritional status, sex hormones and selected bone turnover biochemical markers levels in peri- and postmenopausal women

Abstract

Objectives:Hormonal changes during the peri-and postmenopausal age, especially decreasing estradiol levels as the result of the expired ovarian function, are an established link of the pathogenesis of postmenopausal osteoporosis. The objective of the study was to examine the association between the circulating sclerostin levels and nutritional status, sex hormones and selected bone markers turnover levels in peri-and postmenopausal women. Material and methods:The study enrolled 84 stable-body mass women (31 perimenopausal and 54 postmenopausal). Anthropometric measurements and serum estrone, testosterone, androstenedione, DHEA-S, osteocalcin, β-CTx, 25-OH-Vitamin D and sclerostin levels were obtained.Results: There were not any differences between body mass, BMI, body fat and waist circumference between the study groups. The serum androstenedione and DHEA-S levels were similar in both study groups. However, estrone and total testosterone levels were observed to be notably higher in the perimenopausal group, unlike in the postmenopausal group (124.1 pg/mL vs. 98.3 pg/mL, p < 0.01 and 0.3 pg/mL vs. 0.22 pg/mL, p < 0.01, respectively). Higher plasma osteocalcin and β-CTx levels were shown in the postmenopausal rather than in the perimenopausal group (19.8 ng/mL vs. 16.8 ng/mL, p < 0.001 and 0.35 ng/mL vs. 0.29 ng/mL, p < 0.05, respectively). Plasma sclerostin and 25-OH-Vitamin D levels were similar. There was not any correlation between plasma sclerostin levels and the other studied parameters. In the multivariate regression analyses, sclerostin levels were proportional to the androstenedione ones (b = 0.06; p < 0.05) but inversely related to the log10(testosterone) levels (b = -0.18; p < 0.05). Conclusions:Circulating sclerostin levels are similar in peri-and postmenopausal women and are related to the androstenedione and testosterone levels regardless of the nutritional status.

Circulating bioactive sclerostin levels in an Austrian population-based cohort

“…In kidney transplant recipients, a positive correlation between sclerostin and vitamin D has been found [27]. Nevertheless, in this study in line with a recent investigation of perimenopausal and postmenopausal women [28] no correlation between vitamin D and bioactive sclerostin levels could be detected. Median values of all bone turnover markers were within the normal range.…”

A Risk Assessment Tool for Identifying Osteoporosis in Older Women with Type 2 Diabetes Mellitus

“…Our data are in accordance with previous studies which showed higher serum CTX levels in osteoporotic patients than in non-osteoporosis groups 38 39 . Serum CTX levels are negatively correlated with estrone levels in males and positively correlated with SHBG levels in peri- and postmenopausal women with osteoporosis 40 41 , suggesting a close relationship between the level of BTMs and sex hormones.…”

Evaluation of Trabecular Bone Microarchitecture and Bone Mineral Density in Young Women, Including Selected Hormonal Parameters

“…This protein is already a documented inhibitor of osteoblast proliferation and differentiation, which can lead to bone demineralization [46]. Studies have suggested that one of the important factors that lead to an increase in sclerostin secretion is fluctuations in estrogen concentrations and deficiency, as well as a reduction in bone loading (mechanical stress), leading to a significant loss of bone mass [47,48]. It has also been noted that when thyroid hormone concentrations fluctuate (e.g., thyroid hormone excess), sclerostin levels are high, and after treatment of thyrotoxicosis, sclerostin concentrations decrease [49,50].…”