Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose–response meta‐analysis of epidemiologic studies

Rouhani, Parisa; Hajhashemy, Zahra; Saneei, Parvane

doi:10.1111/obr.13314

Cited by 8 publications

(7 citation statements)

References 63 publications

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“…Some systematic reviews and meta-analyses have examined the relationship between blood vitamin D levels and non-communicable disease (NCDs) and their findings were in line with ours ( 17 , 35 – 37 ). Based on our previous analysis, serum vitamin D was found to be inversely linked to odds of abdominal obesity in a dose-response fashion, in adults ( 17 ).…”

Section: Discussionsupporting

confidence: 80%

“…In another investigation, the highest value of serum vitamin D was significantly associated with a 50% lower risk of metabolic syndrome (MetS) in children. Furthermore, for every 10 ng/mL increase in serum vitamin D, the risk of MetS in children was linearly lowered by 12% ( 35 ). Moreover, a previous meta-analysis showed a weak significant inverse correlation between serum vitamin D level and serum triglycerides (TG) levels in the pediatric age group; but no significant correlation was observed in case of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein (HDL-c) concentrations, or total cholesterol (TC) ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

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Serum Vitamin D Levels in Relation to Abdominal Obesity in Children and Adolescents: A Systematic Review and Dose-Response Meta-Analysis

et al. 2022

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BackgroundFindings of epidemiological studies that investigated the relationship between serum vitamin D levels and abdominal obesity were inconsistent. To evaluate the relationship between blood vitamin D levels and abdominal obesity in children and adolescents, we did a comprehensive review and dose-response meta-analysis.MethodsA comprehensive search in electronic databases including Scopus, Web of Science (ISI), MEDLINE (Pubmed), EMBASE, and Google Scholar was conducted, up to May 2021, for epidemiological studies that investigated the linkage between serum vitamin D levels (as the exposure) and abdominal obesity (as the outcome) in children and adolescents.ResultsCombining 19 effect sizes from 14 cross-sectional studies that included 29,353 apparently healthy children illustrated that the highest vs. lowest level of serum vitamin D was related to a 35% reduced odds of abdominal obesity [odds ratio (OR): 0.65; 95% CI: 0.50, 0.84]. Linear dose-response analysis revealed that each 10 ng/ml increase in serum vitamin D levels was related to a 7% decrease in odds of abdominal obesity (OR: 0.93; 95% CI: 0.90, 0.95), only among investigations that used percentiles of waist circumference (>75th or 90th) to define the disorder (including 6,868 total subjects and 1,075 cases with abdominal obesity). Increasing serum vitamin D levels from 20 to 40 ng/ml was related to reduce odds of abdominal obesity in children.ConclusionA negative relationship between blood vitamin D levels and abdominal obesity in children and adolescents was discovered in this meta-analysis of epidemiologic studies. Among investigations that used waist circumference percentiles to define the disorder, the relationship was in a dose-response manner. To affirm this relationship, more research studies are needed, particularly using a prospective design.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021261319, PROSPERO 2021, identifier: CRD42021261319.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Serum Vitamin D Levels in Relation to Abdominal Obesity in Children and Adolescents: A Systematic Review and Dose-Response Meta-Analysis

et al. 2022

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“…Notably, a significant increase in MetS and VD deficiency among young and middle-aged adults has been observed. Yet, previous studies have predominantly focused on children [30,31], postmenopausal women [32,33], and older populations [24,34,35]. Therefore, our study's focus on investigating the association of circulating 25(OH)D and MetS risk in young and middle-aged individuals is a novel and crucial contribution to the field.…”

Section: (2) Reducing Insulinmentioning

confidence: 99%

Relationship between Circulating 25-Hydroxyvitamin D and Metabolic Syndrome in Chinese Adults: A Large Nationwide Longitudinal Study

Shu,

Xi,

et al. 2024

Nutrients

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Objective: This study investigated the association of circulating levels of 25-hydroxyvitamin D (25[OH]D) with the risk of metabolic syndrome (MetS) and its components in adults. Methods: This nationwide cohort involved 23,810 Chinese adults attending annual health evaluations. Serum 25(OH)D levels, MetS status, and covariates were determined at each examination. Among them, 8146, 3310, and 1971 completed two, three, and more than three evaluations, respectively. A hybrid mixed-effects and Cox regression model was employed to determine the cross-sectional and longitudinal relationships. Results: The odds ratios (ORs) and 95% confidence intervals (CIs) of MetS were significantly lower in individuals within quartile 4 (vs. 1) of serum 25(OH)D for both between-individual (0.43 [0.35, 0.52]) and within-individual comparisons (0.60 [0.50, 0.73]), respectively (all p-trends < 0.001). Among the MetS components, the corresponding ORs (95% CI) in between- and within-individual comparisons were 0.40 (0.29, 0.54) and 0.26 (0.19, 0.36) for abdominal obesity, 0.49 (0.41, 0.58) and 0.78 (0.66, 0.93) for high triglycerides, 0.70 (0.59, 0.82) and 0.75 (0.64, 0.87) for hypertriglyceridemia, 0.48 (0.39, 0.59) and 0.87 (0.71, 1.07) for low HDL cholesterol, and 0.92 (0.76, 1.12) and 0.49 (0.41, 0.59) for hypertension, respectively. Decreased hazard ratios (95% CIs) in quartile 4 (vs. 1) of 25(OH)D were found for MetS (0.80 [0.65, 1.00]), high triglycerides (0.76 [0.62, 0.92]), abdominal obesity (0.77 [0.63, 0.96]), and low HDL cholesterol (0.64 [0.50, 0.81]). Conclusions: Decreased concentrations of serum 25(OH)D correlate significantly to a heightened MetS risk and specific components. Our findings underscore the potential preventive function of circulating vitamin D concerning metabolic disorders.

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“…However, the results in pediatrics remain controversial. 9 In this sense, the present review aimed to observe the correlation between the metabolic syndrome, its individual parameters and hypovitaminosis D in children and adolescents.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome and Hypovitaminosis D in Children and Adolescents: A Systematic Review

Martins

Silva

Santos

et al. 2023

Preprint

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Determine the correlation between metabolic syndrome and hypovitaminosis D in children and adolescents. Data source: systematic review of the literature, PROSPERO registry: CRD42022353545, performed through the evaluation of studies indexed between 2012 and 2022, in the PubMed, ScienceDirect and Web of Science databases. Texts in English and Portuguese were searched for by the DeCS/MeSH descriptors “Metabolic Syndrome” AND “Vitamin D Deficiency” AND Child AND Adolescent. 163 articles were found. After analysis and application of the eligibility criteria, 30 articles were selected. Data synthesis: 28 were observational and 2 were randomized clinical trials. The samples ranged from 29 to 6589 children and adolescents and the age group between 3 and 18 years. A direct relationship between metabolic syndrome and hypovitaminosis D in pediatrics was identified in 15 studies. Regarding the components of the syndrome, 14 articles highlighted obesity, with a higher frequency of vitamin D deficiency or insufficiency in obese children and adolescents. In addition, 10 articles observed an inverse relationship between 25(OH)D levels and glycemic levels. Finally, vitamin D supplementation was associated with improvement in syndrome parameters. Conclusions: Thus, the relationship between metabolic syndrome and hypovitaminosis D in pediatrics is evident. Preventive measures are necessary in order to prevent early and future cardiometabolic complications.

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Circulating serum vitamin D levels in relation to metabolic syndrome in children: A systematic review and dose–response meta‐analysis of epidemiologic studies

Cited by 8 publications

References 63 publications

Serum Vitamin D Levels in Relation to Abdominal Obesity in Children and Adolescents: A Systematic Review and Dose-Response Meta-Analysis

Serum Vitamin D Levels in Relation to Abdominal Obesity in Children and Adolescents: A Systematic Review and Dose-Response Meta-Analysis

Relationship between Circulating 25-Hydroxyvitamin D and Metabolic Syndrome in Chinese Adults: A Large Nationwide Longitudinal Study

Metabolic Syndrome and Hypovitaminosis D in Children and Adolescents: A Systematic Review

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