Circulating vitamin D metabolite concentrations in childhood renal diseases

Chesney, Russell W.; Hamstra, Alan J.; Mazess, Richard B.; Rose, Philip G.; DeLuca, Hector F.

doi:10.1038/ki.1982.9

Cited by 58 publications

(21 citation statements)

References 17 publications

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“…The studies on serum 24,25-(OH)2D3 in anephric pa tients or patients with CRF are conflicting; some authors [12] have shown normal values, others reduced [4,14,21] or undetectable [13,23], This may be explained by an extrarenal C-24 hydroxylase activity which may compen sate for the reduced renal C-24 hydroxylase activity with decreasing renal function.…”

Section: Introductionmentioning

confidence: 93%

Serum Concentrations of Vitamin D Metabolites in Different Degrees of Impaired Renal Function

Rickers

Christiansen

Christensen

et al. 1985

Nephron

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The serum levels of 25-hydroxycholecalciferol, 24,25-dihydroxycholecalciferol, and 1,25-dihydroxycholecalciferol were measured simulataneously in three groups of adults with different renal function: normal (n = 24), glomerular filtration rate (GFR) > 70 ml/min; moderately decreased (n = 15), GFR 5–35 ml/min, and severely decreased (n = 27), GFR < 5 ml/min. 25-hydroxycholecalciferol was normal in both patient groups with decreased renal function. 1,25-dihydroxycholecalciferol was halved in the group with moderately decreased renal function (p < 0.01) and severely decreased (almost undetectable) in the group with severely decreased renal function (p < 0.01). In contrast, 24,25-dihydroxycholecalciferol was normal in the group with moderately decreased renal function and only halved (p < 0.05) in the group with severely decreased renal function. These findings suggest extrarenal C-24 hydroxylase activity which may be stimulated by decreasing renal function, thus decreasing renal C-24 hydroxylase activity.

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Section: Introductionmentioning

confidence: 93%

Serum Concentrations of Vitamin D Metabolites in Different Degrees of Impaired Renal Function

Rickers

Christiansen

Christensen

et al. 1985

Nephron

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“…Numerous other studies have reconfirmed thefindingoflowserum25(OH)D3 concentration in nephrotic patients [20,21,[23][24][25][30][31][32], Low serum concentration of l,25(OH)>D3 was demon strated in adult nephrotic patients by Goldstein et al [23], Lambert et al [31 ], and Haldimann and Trechsei [33] and in some of the nephrotic children studied by Freundlich et al [24] and by A Ion and Chan [25]. The reduction in serum l,25(OH)-2D3 was unlikely due to impairment in the kidney Ia-hydroxylase activity because glomerular filtration rates in the patients were higher than 50 ml/min/1.73 m2 [34,35].…”

Section: Vitamin D and Calcium Metabolismmentioning

confidence: 99%

Calcium and Vitamin D Homeostasis in the Nephrotic Syndrome: Current Status

Alon

Chan²

1984

Nephron

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“…For example, the role of Shigella-like toxins produced by Escherichia coli 1057:H7 and other E. coli strains in the etiology and pathogenesis of HUS is now recognized (50). The role of renal parenchymal atrophy in the failure of the synthesis of 1,25(OH) 2 vitamin D has also been established (51).…”

Section: Research Themes Since 1970mentioning

confidence: 99%

The Development of Pediatric Nephrology

Chesney

2002

Pediatr Res

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The following is the first article in this series. It Pediatric nephrology, as a discipline, arose from descriptive studies of childhood glomerulonephritis in Europe and the field of pediatric metabolism in the United States. While pediatric scientists before 1950 were concerned with fluid and electrolyte metabolism, regulation of intracellular and extracellular fluid, acid-base homeostasis, and parenteral fluid therapy, the defined field of nephrology developed after the Second World War around six major advances: ACTH and glucocorticoid therapy for nephrotic syndrome; renal biopsy to diagnose glomerular disease; the role of immunologic factors in glomerular injury; the use of dialysis as renal replacement therapy; renal transplantation as the optimal form of therapy in children with end stage renal failure; and recognition of renal disease in the etiology of 80% of cases of childhood hypertension. These discoveries led to focused research, the definition of specific training in nephrology, establishment of an American, European, and an International Society of Pediatric Nephrology, as well as an American SubBoard of Pediatric Nephrology, and the inception of a journal, Pediatric Nephrology, now in its 15th year. Major research themes have included developmental nephrology, transplantation immunology, and concerns about growth in children with renal disease. Many clinical entities have been described in detail, some of which are almost confined to children. The scientific basis of pediatric nephrology, ongoing patient care needs, and its technical aspects -renal biopsy, dialysis and transplantationassure its continuing future as a major pediatric discipline on all continents. (Pediatr Res 52: 770-778, 2002) I. THE ORIGINS OF INTEREST IN CHILDHOOD RENAL DISEASES: 1820 -1950The development of the discipline of pediatric nephrology arose from clinical research conducted in the 130-year period from 1820 to 1950. It was during this period that pediatric scientists became interested in the definition of glomerular disorders and in fluid and electrolyte metabolism, the maintenance of normal volume and tonicity and acid-base status, as well as the pathophysiology of such disorders as rickets and diarrhea (1-5) ( Table 1).Pediatric kidney disease was initially considered from a descriptive rather than quantitative perspective. Early treatises on kidney diseases in children were remarkably accurate in terms of their clinical descriptions of various renal disorders, particularly glomerular conditions. In the 11th edition of Eduard Henoch's classic text Kinderkrankheiten (6), he describes

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Circulating vitamin D metabolite concentrations in childhood renal diseases

Cited by 58 publications

References 17 publications

Serum Concentrations of Vitamin D Metabolites in Different Degrees of Impaired Renal Function

Serum Concentrations of Vitamin D Metabolites in Different Degrees of Impaired Renal Function

Calcium and Vitamin D Homeostasis in the Nephrotic Syndrome: Current Status

The Development of Pediatric Nephrology

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