Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community.

Peret, Teresa C. T.; Hall, Caroline B.; Schnabel, Kenneth C.; Golub, Joshua A.; Anderson, Larry J.

doi:10.1099/0022-1317-79-9-2221

Cited by 405 publications

(565 citation statements)

References 34 publications

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“…We also provide evidence for the presence of multiple lineages and genotypes of hMPV, as has been previously observed for other respiratory viruses such as RSV (26,27). …”

Section: Discussionsupporting

confidence: 79%

“…Noting the trend in our results, we speculate that the emergence of subgroup B1 virus may eventually have led to the displacement of subgroup A1 as the dominant viral strain in subsequent years. Similar findings in changes of the dominant group of virus that emerges, fostered by a high prevalence of preexisting community immunity to the other major viral group, have been documented for RSV (26–29). Our study, and another from the Southern Hemisphere (21) showed a high prevalence of subgroup A1 in 2001, a finding that suggests that specific strains may coexist across geographic areas in a given epidemic.…”

Section: Discussionsupporting

confidence: 74%

“…We attempted to group the G sequences of the 4 subgroups into genotypes by using the criteria previously described for RSV (26), in which sequences were arbitrarily considered a genotype if they clustered together with bootstrap values of 70% to 100% (internal nodes at the internal branches). When these criteria were used (only on South African isolates), subgroup A1 could be divided into 5 genotypes, subgroup A2 into 2 genotypes, B1 into 2 genotypes, and B2 into 6 possible genotypes.…”

Section: Resultsmentioning

confidence: 99%

“…Using the criteria described for the existence of multiple lineages for RSV (26), we demonstrated that multiple lineages of hMPV are circulating in South Africa; however, these lineages need to be characterized at the antigenic level and the clinical impact characterized.…”

Section: Discussionmentioning

confidence: 99%

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Human Metapneumovirus Genetic Variability, South Africa

Ludewick

Abed

Niekerk

et al. 2005

Emerg. Infect. Dis.

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The molecular epidemiology and genetic diversity of the human metapneumovirus (hMPV) were characterized for a 3-year period (2000–2002) from viruses that were identified in South Africa. Two major genetic groups (A and B) and 2 subgroups (1 and 2) of hMPV were identified, as well as 2–6 possible genotypes within the subgroups. A shift in the predominant group was documented in successive seasons. Whereas the F gene was relatively conserved between subgroups, a high degree of variation was observed in the extracellular domain of the G gene of the virus. The G protein identities between groups A and B were 45.1%–53.1% at the nucleotide level and 22.4%–27.6% at the amino acid level. These results provide evidence for the diversity of both surface glycoproteins of hMPV in Africa, which may be a prerequisite to understanding protective immunity against hMPV.

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“…We also provide evidence for the presence of multiple lineages and genotypes of hMPV, as has been previously observed for other respiratory viruses such as RSV (26,27). …”

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Human Metapneumovirus Genetic Variability, South Africa

Ludewick

Abed

Niekerk

et al. 2005

Emerg. Infect. Dis.

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“…Although both RSV group A and B strains can circulate in the same season, group A usually predominates [18,21], a phenomenon that also occurred in the present study. In the most intense seasons (1996-1997 and 1999-2000) we detected circulation of group A strains exclusively.…”

Section: Discussionsupporting

confidence: 77%

Hospitalization for respiratory syncytial virus in the paediatric population in Spain

et al. 2003

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SUMMARYThe aim of this population-based retrospective study was to determine the incidence of hospitalization for community-acquired, laboratory-confirmed respiratory syncytial virus (RSV) infection in an unselected paediatric population from southern Europe. The study was performed in an area with 15 700 children aged less than 5 years attended by a single hospital. The presence of RSV in nasopharyngeal aspirates from children with acute respiratory infection treated in the hospital was investigated in four seasons (July 1996-June 2000. A total of 390 episodes of hospitalization for RSV infection were detected and 83 . 3% of the children were aged less than 1 year old. The annual hospitalization rate was 37/1000 for infants aged less than 6 months and 25/1000 for those aged less than 1 year. During the study period, 2 . 5 % of the infants younger than 1 year and approximately 5 % of those younger than 3 months were hospitalized for RSV infection. The mean length of hospital stay was 5 . 9 days. Seven per cent of the patients required admission to the intensive care unit and more than half of these children were aged less than 1 month. In Spain, community-acquired RSV infection is a highly frequent cause of hospitalization in young children, especially in those aged less than 1 year. Prevention of RSV infection, through the development of vaccines and/or other strategies, should be a public health priority.

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