Circulatory effects of internal jugular vein compression: A computer simulation study

Bošnjak, Roman; Kordaš, M.

doi:10.1007/bf02345075

Cited by 16 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So far, mathematical studies of the cranial system have addressed issues such as the coupling between the CSF and the vascular compartment, CSF production and absorption, cerebral autoregulation and the transient behaviour of the CSF system (MARMAROU et al, 1978;SCHMIDT et al, 1997;TAKEMAE et al, 1987;URSINO, 1988a;URSINO and DI GIMMARCO, 1991;URSINO et al, 1995;BOSNJAK and KORDAS, 2002). However, the non-linear nature of the venous system is usually either ignored or addressed indirectly by the parameters of the venous circulation being forced to match the experimental observations in a limited range of PcsF.…”

Section: Da Vcsr CC ---(1) Dpcsfmentioning

confidence: 97%

Mathematical study of the role of non-linear venous compliance in the cranial volume-pressure test

Cirovic

Walsh²,

Fraser

2003

Med. Biol. Eng. Comput.

View full text Add to dashboard Cite

The role of the cerebral venous bed in the cranial volume-pressure test was examined by means of a mathematical model. The cerebral vascular bed was represented by a single arterial compartment and two venous compartments in series. The lumped-parameter formulation for the vascular compartments was derived from a one-dimensional theory of flow in collapsible tubes. It was assumed in the model that the cranial volume is constant. The results show that most of the additional volume of cerebrospinal fluid (deltaV(CSF)) was accommodated by collapse of the cerebral venous bed. This profoundly altered the venous haemodynamics and was reflected in the cranial pressure P(CSF). The cranial volume-pressure curve obtained from the model was consistent with experimental data; the curve was flat for 0 < or = deltaV(CSF) < or = 20 ml and 35 < or = deltaV(CSF) < or = 40 ml, and steep for 20 < or = deltaV(CSF) < or = 35 ml and deltaV(CSF) > or = 40 ml. For deltaV(CSF) > 25 ml and P(CSF) > 5.3 kPa (40 mmHg), cerebral blood flow dropped. When P(CSF) was greater than the mean arterial pressure, all the veins collapsed. The conclusion of the study was that the shape of the cranial volume-pressure curve can be explained by changes in the venous bed caused by various degrees of collapse and/or distension.

show abstract

Section: Da Vcsr CC ---(1) Dpcsfmentioning

confidence: 97%

Mathematical study of the role of non-linear venous compliance in the cranial volume-pressure test

Cirovic

Walsh²,

Fraser

2003

Med. Biol. Eng. Comput.

View full text Add to dashboard Cite

show abstract

“…Because the adult brain is surrounded by the inflexible cranial bones, if arterial flow remains constant but venous flow decreases acutely, blood will accumulate in the capillary system to induce brain swelling, leading to cerebral venous hypertension. One study showed that compression of the internal jugular vein, increasing its pressure from 5 to 10 mm Hg, raises intracranial pressure (ICP) from 9 to 22 mm Hg and cerebrospinal fluid volume from 120 to 145 mL [4]. Elevated cerebral venous pressure subsequently decreases cerebral blood flow and increases ICP, leading to pressure-dependent blood brain barrier disruption [5].…”

Section: Commentmentioning

confidence: 99%

Complete Neurological Recovery After Acute Total Occlusion of the Superior Vena Cava

Liang

Kaiser

Danter

2017

The Annals of Thoracic Surgery

View full text Add to dashboard Cite

Superior vena cava (SVC) syndrome, characterized by swelling of the upper torso, can result from a wide range of causes. The presence and severity of clinical symptoms depends on the degree of stenosis, the location of stenosis, the speed of development of stenosis, and existing collateral flow. Acute complete occlusion of the SVC frequently leads to poor neurologic outcomes such as coma or death. We report a case of a patient who had complete neurologic recovery after 26 minutes of acute total occlusion of the SVC. This report highlights the importance of meticulous management during acute SVC occlusion to improve patient outcome.

show abstract

“…[3][4][5] IJV compression and engorgement of the cranial venous system enlarges the brain and increases brain turgor (makes stiffer) through changes in vascular dynamics and cerebrospinal fluid (CSF) absorption. 3,[6][7][8][9][10][11] This reduces relative motion, or slosh, between the brain and the skull and diminishes deformation of the brain. Two previous animal studies have shown a striking reduction in axonal injury through pre-injury application of a customized cervical collar introducing IJV compression.…”

Section: Introductionmentioning

confidence: 97%

Effect of Internal Jugular Vein Compression on Intracranial Hemorrhage in a Porcine Controlled Cortical Impact Model

Sindelar

Bailes

Sherman

et al. 2017

Journal of Neurotrauma

View full text Add to dashboard Cite

Internal jugular vein (IJV) compression has been shown to reduce axonal injury in pre-clinical traumatic brain injury (TBI) models and clinical concussion studies. However, this novel approach to prophylactically mitigating TBI through venous congestion raises concerns of increasing the propensity for hemorrhage and hemorrhagic propagation. This study aims to test the safety of IJV compression in a large animal controlled cortical impact (CCI) injury model and the resultant effects on hemorrhage. Twelve swine were randomized to placement of a bilateral IJV compression collar (CCI+collar) or control/no collar (CCI) prior to CCI injury. A histological grading of the extent of hemorrhage, both subarachnoid (SAH) and intraparenchymal (IPH), was conducted in a blinded manner by two neuropathologists. Other various measures of TBI histology were also analyzed including: β-amyloid precursor protein (β-APP) expression, presence of degenerating neurons, extent of cerebral edema, and inflammatory infiltrates. Euthanized 5 h after injury, the CCI+collar animals exhibited a significant reduction in total SAH (p = 0.024-0.026) and IPH scores (p = 0.03-0.05) compared with the CCI animals. There was no statistically significant difference in scoring for the other markers of TBI (β-APP, neuronal degeneration, cerebral edema, or inflammatory infiltration). In conclusion, IJV compression was shown to reduce hemorrhage (SAH and IPH) in the porcine CCI model when applied prior to injury. These results suggest the role of IJV compression for mitigation of not only axonal, but also hemorrhagic injury following TBI.

show abstract

Circulatory effects of internal jugular vein compression: A computer simulation study

Cited by 16 publications

References 15 publications

Mathematical study of the role of non-linear venous compliance in the cranial volume-pressure test

Mathematical study of the role of non-linear venous compliance in the cranial volume-pressure test

Complete Neurological Recovery After Acute Total Occlusion of the Superior Vena Cava

Effect of Internal Jugular Vein Compression on Intracranial Hemorrhage in a Porcine Controlled Cortical Impact Model

Contact Info

Product

Resources

About