Circulatory Response to Tilting after Intravenous Diazepam in Volunteers

Diazepam and Local Analgesia for Lumbar Air Encephalography

“…The patients' retrospective comments gave no cause for concern and serve to demonstrate the very dense amnesic action of diazepam used in this way. During die investigations only small, clinically insignificant changes in the mean blood pressure and pulse rates were observed, as was anticipated on the basis of previously reported studies (Katz, Finestone and Pappas, 1967;Dalen et al, 1969).…”

“…10 mm Hg) not associated with an alteration in peripheral resistance was the only other change found in the cardiovascular system. In a series of fit young volunteers, postural hypotension did not occur when diazepam was given intravenously in doses of 10-15 mg (Katz, Finestone and Pappas, 1967). Besides causing little effect on the cardiovascular system, diazepam in doses of 5-10 mg intravenously was found to cause mild respiratory depression not requiring treatment (Dalen et al, 1969).…”

The haemodynamic and hormonal responses after clonidine occur independently of sedation in essential hypertension.

“…Data from previous studies suggests that the effects of benzodiazepines are dose related. Blood pressure does not fall after oral (Knapp et al, 1977;Elliot et al, 1970;Zweifler et al, 1983) and intravenous (Katz et al, 1967;McClish, 1966) (Rao et al, 1972;Elliot et al, 1970). It should be noted however that even severe intoxication with benzodiazepines does not result in a major fall in blood pressure (Greenblatt & Shader, 1974;Matthew et al, 1972).…”

Diazepam and Flunitrazepam as Induction Agents for Cardiac Surgical Operations

“…The literature on diazepam is now very large, and comparative studies are particularly difficult because of uncertainty in defining a true anaesthetic dose. Most workers agree that it is hypotensive, but comparisons suggest that it is less so than the shortacting barbiturates (STOVNER & ENDRESEN 1965, KATZ et al 1967, BROWN & DUNDEE 1968. HEALY et al (1970) reported a fall in cardiac output from 5.8 to 5.1 1/ min after diazepam 0.2 mg/kg, and JENKINSON et al (1974) reported a similar change.…”