Circumcision bleeding complications: neonatal intensive care infants compared to those in the normal newborn nursery

Litwiller, Abigail; Browne, Courtney; Haas, David M.

doi:10.1080/14767058.2017.1319931

Cited by 6 publications

(8 citation statements)

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“…Despite of the known male bias in preterm births, we found no association between prematurity and the gender bias in US SIDS cases, suggesting the existence of stronger factors that determine the gender bias in US populations. Our analyses confirmed that prematurity increases the risk for SIDS and that premature circumcised infants are at a higher risk, in agreement with recent findings indicating that preterm neonates suffer from high rate of bleeding complications following MNC [80], immaturity of their cerebrovascular control in the first year of life [94], and neurodevelopmental complications [95,96], which likely contribute toward the high mortality [24,25].…”

Section: Evaluating the Contribution Of Prematurity Toward Sidssupporting

confidence: 91%

“…Unsurprisingly, SIDS victims experienced significantly more frequent episodes of OSA [79]. Preterm neonates experience over twice the rate of bleeding complications than full-term neonates [80]. MNC-related complications are unavoidable [13,14,[80][81][82] and in tandem with the lack of evidence of a meaningful and relevant health benefits to the infant, several countries chose to opt out of the operation [83].…”

Section: Evaluating the Contribution Of Nmc Toward Sidsmentioning

confidence: 99%

“…Preterm neonates experience over twice the rate of bleeding complications than full-term neonates [80]. MNC-related complications are unavoidable [13,14,[80][81][82] and in tandem with the lack of evidence of a meaningful and relevant health benefits to the infant, several countries chose to opt out of the operation [83]. For instance, in 1949, Gairdner's report [84] that 16 out of 100,000 UK boys under 1-year old died due to circumcision prompted the British government to exclude circumcision coverage from the National Health Service.…”

Section: Evaluating the Contribution Of Nmc Toward Sidsmentioning

confidence: 99%

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Adversarial childhood events are associated with Sudden Infant Death Syndrome (SIDS): an ecological study

Elhaik

2018

Preprint

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Sudden Infant Death Syndrome (SIDS) is the most common cause of postneonatal infant death. The allostatic load hypothesis posits that SIDS is the result of perinatal cumulative painful, stressful, or traumatic exposures that tax neonatal regulatory systems. To test it, we explored the relationships between SIDS and two common stressors, male neonatal circumcision (MNC) and prematurity, using latitudinal data from 15 countries and over 40 US states during the years 1999-2016. We used linear regression analyses and likelihood ratio tests to calculate the association between SIDS and the stressors. SIDS prevalence was significantly and positively correlated with MNC and prematurity rates. MNC explained 14.2% of the variability of SIDS's male bias in the US, reminiscent of the Jewish myth of Lilith, the killer of infant males. Combined, the stressors increased the likelihood of SIDS. Ecological analyses are useful to generate hypotheses but cannot provide strong evidence of causality. Biological plausibility is provided by a growing body of experimental and clinical evidence linking adversary preterm and early-life events with SIDS. Together with historical evidence, our findings emphasize the necessity of cohort studies that consider these environmental stressors with the aim of improving the identification of at-risk infants and reducing infant mortality.

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Section: Evaluating the Contribution Of Prematurity Toward Sidssupporting

confidence: 91%

Section: Evaluating the Contribution Of Nmc Toward Sidsmentioning

confidence: 99%

Section: Evaluating the Contribution Of Nmc Toward Sidsmentioning

confidence: 99%

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Adversarial childhood events are associated with Sudden Infant Death Syndrome (SIDS): an ecological study

Elhaik

2018

Preprint

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“…Unsurprisingly, SIDS victims experienced significantly more frequent episodes of OSA [122]. Preterm neonates experience over twice the rate of bleeding complications than full-term neonates [123]. MNC-related complications are unavoidable [16][17][18][123][124][125].…”

Section: Evaluating the Contribution Of Mnc Toward Sidsmentioning

confidence: 99%

“…Preterm neonates experience over twice the rate of bleeding complications than full-term neonates [123]. MNC-related complications are unavoidable [16][17][18][123][124][125]. For instance, in 1949, Gairdner reported [126] that 16 out of 100,000 UK boys under 1-year old died due to circumcision.…”

Section: Evaluating the Contribution Of Mnc Toward Sidsmentioning

confidence: 99%

Neonatal circumcision and prematurity are associated with sudden infant death syndrome (SIDS)

Elhaik

2018

J Clin Transl Res

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Background: Sudden infant death syndrome (SIDS) is the most common cause of postneonatal unexplained infant death. The allostatic load hypothesis posits that SIDS is the result of cumulative perinatal painful, stressful, or traumatic exposures that tax neonatal regulatory systems. Aims: To test the predictions of the allostatic load hypothesis we explored the relationships between SIDS and two common phenotypes, male neonatal circumcision (MNC) and prematurity. Methods: We collated latitudinal data from 15 countries and 40 US states sampled during 2009 and 2013. We used linear regression analyses and likelihood ratio tests to calculate the association between SIDS and the phenotypes. Results: SIDS mortality rate was significantly and positively correlated with MNC. Globally (weighted): Increase of 0.06 (95% CI: 0.01-0.1, t = 2.86, p = 0.01) per 1000 SIDS mortality per 10% increase in circumcision rate. US (weighted): Increase of 0.1 (95% CI: 0.03-0.16, t = 2.81, p = 0.01) per 1000 unexplained mortality per 10% increase in circumcision rate. US states in which Medicaid covers MNC had significantly higher MNC rates (χ = 0.72 vs 0.49, p = 0.007) and male/female ratio of SIDS deaths (χ = 1.48 vs 1.125, p = 0.015) than other US states. Prematurity was also significantly and positively correlated with MNC. Globally: Increase of 0.5 (weighted: 95% CI: 0.02-0.086, t = 3.37, p = 0.004) per 1000 SIDS mortality per 10% increase in the prematurity rates. US: Increase of 1.9 (weighted: 95% CI: 0.06-0.32, t = 3.13, p = 0.004) per 1000 unexplained mortalities per 10% increase in the prematurity rates. Combined, the phenotypes increased the likelihood of SIDS. Conclusions: Epidemiological analyses are useful to generate hypotheses but cannot provide strong evidence of causality. Biological plausibility is provided by a growing body of experimental and clinical evidence linking aversive preterm and early-life SIDS events. Together with historical and anthropological evidence, our findings emphasize the necessity of cohort studies that consider these phenotypes with the aim of improving the identification of at-risk infants and reducing infant mortality. Relevance for patients: Preterm birth and neonatal circumcision are associated with a greater risk of SIDS, and efforts should be focused on reducing their rates.

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Systematic review of complications arising from male circumcision

2021

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Background: Neonatal male circumcision is the most common procedure performed on paediatric patients (Simpson et al., 2014) and one of the most common surgical procedures in the world (American Academy of Pediatrics, 2012).Methods: A search was conducted for articles about complications arising from male circumcision surgeries by entering the term 'male circumcision' into PubMed on June 16, 2020. Six thousand six hundred forty-one articles published from 1945 to 2020 were found. Seventy-eight articles were ultimately selected for the systematic review.Results: The 78 articles selected from the literature search were entered into one of three tables. The first table includes 15 articles pertaining to chart reviews and cohort studies and report complication rates. The second table reports specific complications from 51 case reports and case series, and the third table is a summary from 12 articles regarding physician questionnaires and society recommendations. Additionally, the 78 articles were used to compile a list of 47 specific complications arising from male circumcision surgeries.Conclusions: Complications from neonatal male circumcisions are common and healthcare providers need to be better informed of the potential complications of the surgery so that they can more effectively counsel their patients about potential risks, likelihood of complications and what can be done to prevent them. While experienced providers who practice in sterile settings have better outcomes with fewer complications, encouraging parents to take into account who is performing their son's circumcision, what was their training, how clean is their practice and how much experience they have and reminding them they have the option to decline the procedure entirely allow the parents to get a more complete picture and play an essential role in the decision-making process.

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Circumcision bleeding complications: neonatal intensive care infants compared to those in the normal newborn nursery

Cited by 6 publications

References 4 publications

Adversarial childhood events are associated with Sudden Infant Death Syndrome (SIDS): an ecological study

Adversarial childhood events are associated with Sudden Infant Death Syndrome (SIDS): an ecological study

Neonatal circumcision and prematurity are associated with sudden infant death syndrome (SIDS)

Systematic review of complications arising from male circumcision

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