Circumscribed palmar hypokeratosis: Successful treatment with fluorouracil cream

Wilk, Michael; Zelger, Bettina; Zelger, Bernhard

doi:10.1007/s13555-011-0002-2

Cited by 13 publications

(10 citation statements)

References 12 publications

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“…On that occasion, biopsy of 1 of the thenar lesions showed the specific findings of circumscribed hypokeratosis. 38 There was no improvement after the use of topical 5-fluorouracil in 2 other patients. 21,24 Topical calcipotriol was effective in 1 case, with complete regression after prolonged use for more than 4 years; the patient presented a slow but progressive improvement of a lesion that had been present and stable in size and shape for around 30 years.…”

Section: Treatmentmentioning

confidence: 86%

“…Most lesions were located on the right palm, mainly affecting the thenar region (44 of 79 lesions). Lesions affecting the digits have been detected in isolated cases, 2,11,16,24,27,31,34,38,41 most commonly on the thumb, 2,11,16,27,31,34 but in 1 case on the dorsum of the index finger. 24 Lesions have also been reported on the palm, 26 on the dorsum or border of the feet, 24,34,44 and on the sole.…”

Section: Clinical Presentationmentioning

confidence: 99%

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Circumscribed Palmar or Plantar Hypokeratosis 10 Years After the First Description: What Is Known and the Issues Under Discussion

Urbina¹,

Pérez²,

Requena³

et al. 2014

Actas Dermo-Sifiliográficas (English Edition)

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This review of the literature on palmoplantar hypokeratosis, a process that was first indentified only 10 years ago, discusses the current state of our understanding, the therapeutic options available, and the debate about etiology. Forty-four publications reporting 69 cases were found. Palmar or plantar hypokeratosis occurs mainly in women (76.8%) and age at the time of a first visit to a physician ranges from 42 to 84 years. Most cases present between the ages of 51 and 70 years. The majority of patients have had solitary lesions usually located on the right palm, particularly in the regions of the thenar (in 44/79 lesions [55.7%]) or hypothenar eminences (in 11/79 lesions [13.9%]). In only 8 cases was there a history of prior trauma at the site. Studies using polymerase chain reaction techniques to identify human papillomavirus involvement were negative in most cases. These hypokeratotic lesions are localized epidermal depressions formed by an abrupt thinning of the stratum corneum, providing a singular histopathologic feature. This condition can currently be considered a localized keratinization disorder affecting zones where there is a thick stratum corneum. The precipitating cause is unknown and a definitive treatment remains to be found. The mechanism would be the localized failure of a clone of keratinocytes during differentiation toward normal palmoplantar hyperkeratinization. Palmas y plantas; Hipoqueratosis circunscrita palmar o plantar. Conocimientos y controversias tras 10 años de su descripciónResumen Se revisa el estado actual de un nuevo proceso y los avances que han ido apareciendo en la literatura respecto a su estudio, posibilidades terapéuticas y controvertida etiología, tras ଝ Please cite this article as: Urbina F, Pérez A, Requena L, Rütten A. Hipoqueratosis circunscrita palmar o plantar. Conocimientos y controversias tras 10 años de su descripción. Actas Dermosifiliogr. 2014;105:574---582.Palmar or Plantar Hypokeratosis 575 Palmoplantar; Queratinización; Queratinocito justo una década de su descripción inicial. Hemos encontrado 44 publicaciones al respecto, con 69 casos. Predomina en mujeres (76,8%), con edades entre los 42 y 84 años para toda la casuística en el momento de la consulta, siendo el rango más frecuente de aparición de las lesiones entre los 51 y 70 años. La gran mayoría de las veces fueron lesiones únicas y se localizaron predominantemente en la palma derecha, preferentemente en la región tenar, con 44/79 lesiones (55,7%) y luego en la hipotenar, con 11/79 lesiones (13,9%). Solo en 8 casos se obtuvo el antecedente de un traumatismo previo. Los estudios mediante PCR en búsqueda de papiloma virus humano han sido negativos la gran mayoría de las veces. Las lesiones consistieron en una depresión focalizada de la epidermis producida por una brusca disminución de espesor de la capa córnea, delimitando un singular concepto histolopatológico. En la actualidad puede ser considerada como un trastorno focalizado de la queratinización, que afecta zonas con un estrato córneo grueso, cuya c...

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Section: Treatmentmentioning

confidence: 86%

Section: Clinical Presentationmentioning

confidence: 99%

Circumscribed Palmar or Plantar Hypokeratosis 10 Years After the First Description: What Is Known and the Issues Under Discussion

Urbina¹,

Pérez²,

Requena³

et al. 2014

Actas Dermo-Sifiliográficas (English Edition)

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“…Plantar lesions show a decreased expression of these proteins compared to palmar lesions . Loss of palm‐skin‐specific differentiation is hypothesized as the cause of CPH without keratin 9 expression …”

mentioning

confidence: 99%

“…Clinical examination usually reveals a rounded, well‐circumscribed erythematous depressed lesion with a slightly raised scaly border. Its size ranges from a few mm up to 6 cm, most frequently measuring around 15 mm . The lesion is usually asymptomatic and persists for several years without morphological or size changes …”

mentioning

confidence: 99%

“…The second feature is the well‐demarcated homogeneous erythema with regularly‐distributed tiny white spots, better seen with oil immersion . The erythematous base might result from a combination of a thinned stratum corneum that highlights the dermal vessels through the epidermis, dilated capillaries in the papillary dermis (which explains the small red dots commonly seen over the basal erythema), and chronic inflammatory infiltrate .…”

mentioning

confidence: 99%

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Circumbscribed palmar hypokeratosis

et al. 2019

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Inherited Disorders of Cornification

Oji

Metze

Traupe

2016

Rook's Textbook of Dermatology, Ninth Edition

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The majority of keratinization disorders are referred to as Mendelian disorders of cornification. This is a very broad group, clinically characterized by hyperkeratosis or visible scaling or both. This chapter deals with the ichthyoses, palmoplantar keratodermas (PPKs) and miscellaneous cornification disorders such as porokeratoses. It is aimed primarily at dermatologists and physician scientists who have to make a clinical diagnosis and provide adequate management for their patients. Therefore a nosology and classification scheme has been chosen that is based on clinicogenetic and morphological features. Clinical diagnoses are then discussed with their molecular pathology. Part of the chapter addresses the management of congenital ichthyoses. Various tables provide an overview on clinical and/or pathophysiologically related groups of diseases. Finally, several cornification disorders are discussed that do not have a genetic basis, but are acquired or are of unknown aetiology (e.g. acquired ichthyoses/PPKs or perforating keratotic disorders).

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Circumscribed palmar hypokeratosis: Successful treatment with fluorouracil cream

Cited by 13 publications

References 12 publications

Circumscribed Palmar or Plantar Hypokeratosis 10 Years After the First Description: What Is Known and the Issues Under Discussion

Circumscribed Palmar or Plantar Hypokeratosis 10 Years After the First Description: What Is Known and the Issues Under Discussion

Circumbscribed palmar hypokeratosis

Inherited Disorders of Cornification

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