CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer

Li, Ding; Xie, Zhibing

doi:10.1016/j.yexmp.2021.104704

Cited by 19 publications

(15 citation statements)

References 19 publications

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“…CircRNAs have been reported to play critical roles in the tumorigenesis of NSCLC by acting as oncogenes or tumor suppressors 27–29 . CircWHSC1 serves as an oncogene in ovarian cancer, endometrial cancer, HCC, and breast cancer and improves tumor cell proliferation, migration and invasion 19–22 . Herein, enhanced expression of circWHSC1 was first detected in NSCLC tissues and cells.…”

Section: Discussionmentioning

confidence: 98%

“…[27][28][29] CircWHSC1 serves as an oncogene in ovarian cancer, endometrial cancer, HCC, and breast cancer and improves tumor cell proliferation, migration and invasion. [19][20][21][22] Herein, enhanced expression of circWHSC1 was first detected in NSCLC tissues and cells. In addition, survival analysis suggested that NSCLC patients with high expression of circWHSC1 were expected to have a poor prognosis, demonstrating that circWHSC1 might be utilized as an independent indicator for dynamic monitoring of NSCLC.…”

Section: Discussionmentioning

confidence: 99%

“…In HCC, CircWHSC1 plays a tumor‐promoting role by elevating HOXA1 through sponging miR‐142‐3p 21 . In addition, circWHSC1 accelerated malignancy of breast cancer by the miR‐212‐5p/AKT3 axis 22 or through modulating the miR‐195‐5p/FASN/AMPK/mTOR pathway 23 . Recently, circWHSC1 was reported to regulate the expression of LTBP2 by sponging miR‐532‐3p and promote the tumorigenesis of cervical cancer 24 .…”

Section: Introductionmentioning

confidence: 99%

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CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis

Wang

et al. 2023

Environmental Toxicology

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Dysregulated circWHSC1 has been shown to play potential roles in diverse cancer types, including ovarian cancer, endometrial cancer and hepatocellular carcinoma (HCC). The objective of this study was to investigate its expression, underlying role and regulatory mechanism in non‐small‐cell lung cancer (NSCLC). The expression of circWHSC1 was determined by real‐time PCR. After knockdown of circWHSC1 expression in NSCLC cells, the proliferation, migration, and invasion were detected using CCK‐8, colony formation, and Transwell assays, and the effects of circWHSC1 on NSCLC tumorigenesis in vivo was also investigated. With the help of luciferase reporter and pull‐down assays, we further explored the downstream mechanism of circWHSC1 in NSCLC cells. CircWHSC1 was highly expressed in NSCLC tissues and cell lines. The inhibition of circWHSC1 suppressed the malignant properties of NSCLC cells, as evidenced by the reduction of proliferation, migration and invasion. CircWHSC1 sponged miR‐590‐5p and functioned as an oncogene in NSCLC by increasing sex determining region Y‐boxprotein 5 (SOX5) expression. CircWHSC1 may contribute to the oncogenicity of NSCLC via the regulation of miR‐590‐5p/SOX5 axis, which might be a novel therapeutic target in NSCLC.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis

Wang

et al. 2023

Environmental Toxicology

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“…CircRNAs can be detected in clinical blood samples, saliva, and exosomes. In recent years, a large number of studies have shown that circRNAs are involved in TNBC cell proliferation, apoptosis, migration, and invasion (Chen, Wang, et al, 2021; Ding & Xie, 2021; Tian et al, 2021). Although circRNAs have been reported to be involved in chemoresistance in various cancers, there has been no systematic review of the above studies.…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs in the chemoresistance of triple‐negative breast cancer: A systematic review

Wang

Shan

Peng

et al. 2023

Drug Development Research

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This study aims to assess studies on circular RNAs (circRNAs) in the chemoresistance of triple‐negative breast cancer (TNBC) and provide relevant references for the development of new TNBC chemotherapy sensitivity biomarkers and therapeutic targets. The PubMed, Embase, Web of Knowledge, Cochrane Library, and four Chinese databases were searched up to January 27, 2023, and studies related to TNBC chemoresistance were included. The basic characteristics of the studies and the mechanisms of circRNAs in regulating TNBC chemoresistance were analyzed. A total of 28 studies published between 2018 and 2023 were included, and the chemotherapeutics included adriamycin, paclitaxel, docetaxel, 5‐fluorouracil, lapatinib, and so forth. A total of 30 circRNAs were identified, 86.67% (n = 26) of these circRNAs were reported to act as microRNA (miRNA) sponges to regulate chemotherapy sensitivity, while only two circRNAs (circRNA‐MTO1 and circRNA‐CREIT) interacted with proteins. A total of 14, 12, and 2 circRNAs were reported to be associated with chemoresistance to adriamycin, taxanes, and 5‐fluorouracil, respectively. Six circRNAs were found to act as miRNA sponges that promote chemotherapy resistance by regulating the PI3K/Akt signalling pathway. CircRNAs participate in the regulation of TNBC chemoresistance and can be used as biomarkers and therapeutic targets for improving chemotherapy sensitivity. However, further studies are needed to confirm the role of circRNAs in TNBC chemoresistance.

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“…Growing evidence has demonstrated that cir-cRNAs ate involved in the progression many of cancers [8][9][10], including breast cancer [11]. For instance, cir-cRNA circWHSC1 was highly expressed and promoted the growth, metastasis and glycolysis of BC cells through regulating miR-212-5p and AKT3 [12]. CircPRMT5 was increased in BC and accelerated the proliferation and migration of BC cells [13].…”

Section: Introductionmentioning

confidence: 99%

CircCEP85 upregulates IGF1 expression to promote breast cancer progression via sponging miR-1193

Gao

Han

et al. 2022

Appl Biol Chem

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Background Increasing evidence has suggested that circular RNAs (circRNAs) play critical roles in breast cancer (BC) progression. However, the expression level and potential functional role of circRNA centrosomal protein 85 (circCEP85) in BC remains largely unknown. Here, we aimed to explore the role of circCEP85 in BC. Methods The levels of circCEP85, insuline-like growth factor I (IGF1) mRNA and microRNA-1193 (miR-1193) were examined by quantitative real-time polymerase chain reaction. The protein level was measured by Western blot. Cell proliferation, migration, apoptosis, angiogenesis and stemness were assessed by cell counting kit-8, 5-ethynyl-2’-deoxyuridine assay, transwell assay, flow cytometry, tube formation and sphere formation assays. Xenograft mouse models were conducted to evaluate the effect of circCEP85 in BC in vivo. Moreover, dual-luciferase reporter, RNA pull-down, and RNA immunoprecipitation (RIP) assays were preformed to confirm the interaction between miR-1193 and circCEP85 or IGF1. Results CircCEP85 was upregulated in BC tissues and cells. Silencing of circCEP85 inhibited proliferation, invasion, angiogenesis and stemness, but promoted apoptosis in BC cells in vitro. In addition, circCEP85 silencing inhibited tumor growth in vivo. Mechanistically, circCEP85 elevated IGF1 expression via sponging miR-1193 to promote breast cancer progression. Conclusion The circCEP85-miR-1193-IGF1 axis regulated BC progression via the competitive endogenous RNA (ceRNA) mechanism. CircCEP85 might be a prognostic biomarker and therapeutic target for BC.

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CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer

Cited by 19 publications

References 19 publications

CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis

CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis

Circular RNAs in the chemoresistance of triple‐negative breast cancer: A systematic review

CircCEP85 upregulates IGF1 expression to promote breast cancer progression via sponging miR-1193

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