Cis- and trans-dihalotetrakis(dimethyl sulfoxide)ruthenium(II) complexes (RuX2(DMSO)4; X = Cl, Br): synthesis, structure, and antitumor activity

Alessio, Enzo; Mestroni, G.; Nardin, Giorgio; Attia, W. M.; Calligaris, M.; Sava, Gianni; Zorzet, Sonia

doi:10.1021/ic00296a006

Cited by 322 publications

(207 citation statements)

References 6 publications

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“…(ptaMe)CF3SO3 [25] was kindly supplied by Prof. A. Romerosa (U. Almería, Spain). 1 is a light sensitive compound, [9,53] therefore its reactions were studied with the careful exclusion of light.…”

Section: General Remarksmentioning

confidence: 99%

“…[6,7] The ruthenium(II) dimethylsulfoxide complexes, cis-and trans-[RuCl2(dmso)4] are conveniently prepared and easy-to-handle compounds. [8,9] Earlier cis-[RuCl2(dmso)4], 1 was used as precursor for the synthesis of Ru(II)-complexes with aryl, sulfonated aryl, and cyclohexyl phosphanes, both in aqueous and in non-aqueous media. [8,[10][11][12][13][14] In addition, several ligands with N-and O-donor atoms were studied in substitution reactions of both isomers of [RuCl2(dmso)4].…”

Section: Introductionmentioning

confidence: 99%

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The dual role of cis-[RuCl2(dmso)4] in the synthesis of new water-soluble Ru(II)–phosphane complexes and in the catalysis of redox isomerization of allylic alcohols in aqueous–organic biphasic systems

Udvardy

Bényei

Kathó

2012

Journal of Organometallic Chemistry

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New air-stable, water-soluble Ru(II)-phosphane complexes were synthesized in high purity by the reaction of cis-[RuCl2(dmso)4] with 2 equivalents of 1,3,5-triaza-7-phosphaadamantane (pta) and its N-methyl and N-benzyl derivatives (pta-Me and pta-Bn, respectively). All new complexes were characterized by elementary analysis and spectroscopic methods (NMR, ESI  1 and the new complexes actively catalyzed the isomerization of allylic alcohols. MS) and the molecular structures of cis-cis-trans-[RuCl2(dmso)2(pta)2], cis-cis-trans-

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Section: General Remarksmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The dual role of cis-[RuCl2(dmso)4] in the synthesis of new water-soluble Ru(II)–phosphane complexes and in the catalysis of redox isomerization of allylic alcohols in aqueous–organic biphasic systems

Udvardy

Bényei

Kathó

2012

Journal of Organometallic Chemistry

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“…The hydrolytic chemistry of cis-and trans-[RuCl 2 (DMSO) 4 ] has been examined thoroughly in other studies, 35 and is illustrated schematically in Figure 3. Immediately after dissolution in water, trans-[RuCl 2 (DMSO) 4 3-, contains either a 2-or 3-coordinate ruthenium, depending on whether the oligonucleotide is bound to the metal through one or two bases (more below).…”

Section: Reactions Involving Cis-and Trans-[rucl 2 (Dmso) 4 ]mentioning

confidence: 99%

Electrospray ionisation mass spectrometry of ruthenium and palladium complexes with oligonucleotides

Beck¹,

Humphries²,

Sheil³

et al. 1999

Eur. J. Mass Spectrom.

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Electrospray ionisation mass spectrometry (ESI-MS) was used to characterise complexes formed in reactions between[Pd(en)Cl 2 ] reacted more extensively with 5′-GGCTAGCC-3′ than the ruthenium complexes, since ESI mass spectra showed ions arising from complexes containing two, three and four Pd(en) moieties bound to the oligonucleotide. Mass spectra obtained after purifying the reaction mixture by HPLC indicated that the major complex contained only two Pd(en) units bound to the oligonucleotide, suggesting that ions containing three or four Pd(en) units were formed predominantly by gas-phase chemistry in the ion source.

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“…Recent publications have focused on the chemistry of geometrical isomers of ruthenium(I1) sulfoxide complexes of the type [RuX,(drnso),], where X = C1, Br; dmso = dimethylsulfoxide, with special emphasis on their pronounced antitumor activity (1,2). These complexes can strongly bind to guanine bases, and by analogy to cisplatin they seem to inhibit the restriction enzymes that recognize DNA sequences containing two or more adjacent guanines (3).…”

Section: Introductionmentioning

confidence: 99%

Linkage isomerization and electrochemical behavior of two geometrical isomers of dichlorobis(dimethylsulfoxide)bis(t-butylpyridine)ruthenium(II)

Silva¹,

Toma²

1994

Can. J. Chem.

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DENISE 0 . SILVA and HENRIQUE E. TOMA. Can. J. Chem. 72, 1705Chem. 72, (1994. The reaction of cis- [RuCl,(dmso),] (dmso = dimethylsulfoxide) with 4-tert-butylpyridine (tbpy) in chloroform leads to the all cis (ccc) and the cis,cis,trans (cct) geometrical isomers of [RuCl,(S-dmso),(tbpy),]. The cct isomer exhibits a reversible cyclic voltammogram, ascribed to the RU"'"' redox couple with Ell, = 1.12 V versus SHE. The ccc isomer can be oxidized at Ell, = 1.27 V; however, the oxidized species undergoes a relaxation equilibrium, (K,,, = 1.59), involving the S-to-0 linkage isomerization of a coordinated dmso ligand (k,,, 1.9 s-I and kojS = 1.2 s-I). The isomerization reaction in the RU"' ccc isomer is discussed in terms of the competitive effects between the S-bound dmso and the tbpy ligands. DENISE 0 . SUVA et HENRIQUE E. TOMA. Can. J. Chem. 72, 1705 (1994). La rkaction du cis-[RuCl,(dmso),] (dmso = dimCthylsulfoxyde) avec la 4-tert-butylpyridine (tbpy) dans le chloroforme conduit B la formation des isomkres gkomktriques complktement cis (ccc) et cis,cis,trans (cct) du [RuCl,(drnso),(tbpy),]. L'isomkre cct prksente un voltampCrogramme cyclique rkversible, attribuC au couple rkdox R U~~" ' , avec Ell, = 1,12 V versus SHE.L'isomkre ccc peut Ctre oxydC i i E,/, = 1.27 V; toutefois, les espkces oxydCes subissent un Cquilibre de relaxation (K,,, = 1,59) impliquant 1'isomCrisation d'un coordinat dmso de la liaison S vers 0 (k,,, = 1,9 s-I et k, , , = 1,2 s-I). On discute de la rkaction d7isomCrisation de l'isomkre ccc du RU"' en fonction des effets compktitifs entres les coordinats tbpy et dmso liC par le S.[Traduit par la redaction]

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Cis- and trans-dihalotetrakis(dimethyl sulfoxide)ruthenium(II) complexes (RuX2(DMSO)4; X = Cl, Br): synthesis, structure, and antitumor activity

Abstract: cisand trans-Dihalotetrakis(dimethyl sulfoxide)ruthenium(II) Complexes (RuX2(DMSO)4; X = Cl, Br): Synthesis, Structure

Cited by 322 publications

References 6 publications

The dual role of cis-[RuCl2(dmso)4] in the synthesis of new water-soluble Ru(II)–phosphane complexes and in the catalysis of redox isomerization of allylic alcohols in aqueous–organic biphasic systems

The dual role of cis-[RuCl2(dmso)4] in the synthesis of new water-soluble Ru(II)–phosphane complexes and in the catalysis of redox isomerization of allylic alcohols in aqueous–organic biphasic systems

Electrospray ionisation mass spectrometry of ruthenium and palladium complexes with oligonucleotides

Linkage isomerization and electrochemical behavior of two geometrical isomers of dichlorobis(dimethylsulfoxide)bis(t-butylpyridine)ruthenium(II)

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