cis-Dichlorodiammine platinum(II) induced aberrations in mouse bone-marrow chromosomes

Tandon, Priti; Sodhi, Ajit

doi:10.1016/0165-1218(85)90063-1

Cited by 18 publications

(4 citation statements)

References 12 publications

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“…It has numerous genotoxic effects which are characteristic of drugs which cause DNA damage. For example, the compound is mutagenic in bacteria 15,16) and mammalian cells 17,18) where it also produces chromosomal abnormalities [19][20][21][22]. It inhibits bacteriophages 23) and transforming DNA [24][25][26].…”

Section: Thetargetmentioning

confidence: 99%

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Johnson

Butour

Villani

et al. 1989

Progress in Clinical Biochemistry and Medicine

164

122

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Cisplatin (cis-diamminedichloroplatinum(II») is widely used in the treatment of testicular and ovarian cancers. A number of biological and biochemical results indicate that the reaction of cisplatin with DNA is responsible for the cytotoxic action of this drug. The effect of platinum compounds on the conformation and stability of DNA has been investigated and several platinum-DNA adducts have been identified in vitro and in vivo. Preliminary experiments have quantified the effect of these different lesions on DNA replication, their capacity to induce mutations and their susceptibility to DNA repair processes. Additional DNA damage may be created by platinum(IV) compounds, perhaps during their reduction to platinum(II) compounds by the cell.

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Section: Thetargetmentioning

confidence: 99%

Metal Antitumor Compounds: The Mechanism of Action of Platinum Complexes

Johnson

Butour

Villani

et al. 1989

Progress in Clinical Biochemistry and Medicine

164

122

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“…We found no significant chromosome abnormalities or micronuclei in either condition. At least in TG cells, compound 1 did not show clastogenic effects like those reported by Tandon in mouse bone-marrow treated with cisplatin [32].…”

Section: Interaction Of H[rucl 2 (Pdta-h 2 )] With Cultured Tumor Cellsmentioning

confidence: 75%

Synthesis, interaction with double-helical DNA and biological activity of the water soluble complex cis-dichloro-1,2-propylenediamine-N,N,N′,N′-tetraacetato ruthenium (III) (RAP)

Vilaplana

Delmani

Manteca

et al. 2006

Journal of Inorganic Biochemistry

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“…Of the various possible binding modes it was suggested that those at the N-7 positions of adenine and guanine were the most likely sites to be involved in reactions with DNA (Zamble andLippard 1995, Fichtinger-Schepman et al 1995). Development of chromsomal aberrations in the cells have been commonly used as the mutagenic bioassays of a drug (Tandon andSodhi 1985, Giri andPrasad 1996 later periods could be due to various possible reasons such as the clearance of drug from the body, post-replication repair process etc because of which many of the Pt-DNA adducts could be cleared. Infact a relation between the drug-sensitivity and poor cisplatin-DNA adducts repair has been established (Dijt et al 1988, Zamble andLippard 1995).…”

Section: Discussionmentioning

confidence: 99%