cis-Khellactone Inhibited the Proinflammatory Macrophages via Promoting Autophagy to Ameliorate Imiquimod-Induced Psoriasis

Li, Feng; Song, Pingping; Xu, Fang; Xu, Li; Shao, Fenli; Guo, Ming; Huang, Wei; Kong, Ling-Dong; Wu, Xudong; Xu, Qiang

doi:10.1016/j.jid.2019.02.021

Cited by 30 publications

(28 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Psoriasis is a chronic immune-mediated inflammatory disorder, histologically featuring as abnormal proliferation/differentiation of keratinocytes, excessive angiogenesis, and inflammatory cell infiltration in the dermis [ 100 ]. It has a great impact on the physical and psychological health of patients [ 101 – 103 ], but few therapeutic strategies are enough to satisfy.…”

Section: Macrophage Polarization In Vascular Dermatosismentioning

confidence: 99%

Regulating the Polarization of Macrophages: A Promising Approach to Vascular Dermatosis

Peng

Xian

Liu

et al. 2020

Journal of Immunology Research

View full text Add to dashboard Cite

Macrophages, a kind of innate immune cells, derive from monocytes in circulation and play a crucial role in the innate and adaptive immunity. Under the stimulation of the signals from local microenvironment, macrophages generally tend to differentiate into two main functional phenotypes depending on their high plasticity and heterogeneity, namely, classically activated macrophage (M1) and alternatively activated macrophage (M2). This phenomenon is often called macrophage polarization. In pathological conditions, chronic persistent inflammation could induce an aberrant response of macrophage and cause a shift in their phenotypes. Moreover, this shift would result in the alteration of macrophage polarization in some vascular dermatoses; e.g., an increase in proinflammatory M1 emerges from Behcet’s disease (BD), psoriasis, and systemic lupus erythematosus (SLE), whereas an enhancement in anti-inflammatory M2 appears in infantile hemangioma (IH). Individual polarized phenotypes and their complicated cytokine networks may crucially mediate in the pathological processes of some vascular diseases (vascular dermatosis in particular) by activation of T cell subsets (such as Th1, Th2, Th17, and Treg cells), deterioration of oxidative stress damage, and induction of angiogenesis, but the specific mechanism remains ambiguous. Therefore, in this review, we discuss the possible role of macrophage polarization in the pathological processes of vascular skin diseases. In addition, it is proposed that regulation of macrophage polarization may become a potential strategy for controlling these disorders.

show abstract

Section: Macrophage Polarization In Vascular Dermatosismentioning

confidence: 99%

Regulating the Polarization of Macrophages: A Promising Approach to Vascular Dermatosis

Peng

Xian

Liu

et al. 2020

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…2c-d), thus disrupting the induction of innate immunity. Moreover, innate cytokines generated from proin ammatory macrophages directly target effector KCs, leading to the production of in ammatory mediators, such as h-BD2, S100A7, CXCL1 and IL-36R [28]. These inotropic cytokines, in turn, recruit excessive macrophages in ltration to form an innate cytokine loop in psoriatic lesions [6,29].…”

Section: Resultsmentioning

confidence: 99%

A Multifunctional Composite Hydrogel as an Intrinsic and Extrinsic Coregulator for Enhanced Therapeutic Efficacy for Psoriasis

Chen

Chu

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Psoriasis is a chronic relapsing immunological skin disease characterized by multiple cross-talk inflammatory circuits which are relevantly associated with abnormal cross-reactivity between immune cells and keratinocytes (KCs). It may be inadequate to eradicate complicated pathogenesis only via single-mode therapy. To provide optimal combinatory therapeutics, a nanocomposite-based hydrogel was constructed by loading methotrexate (MTX) into ZnO/Ag to realize synergistic multiple target therapy of psoriasis. Results In this composite hydrogel, ZnO hybrid mesoporous microspheres were utilized both as drug carriers and ROS-scavenging nanoparticles. A proper amount of Ag nanoparticle-anchored ZnO nanoparticles (ZnO/Ag) was functionalized with inherent immunoregulatory property. The experiments showed that ZnO/Ag nanoparticles could exhibit a self-therapeutic effect that was attributed to reducing innate cytokine profiles by inactivating p65 in proinflammatory macrophages and abrogating secretion of adaptive cytokines in KCs by downregulating ROS-mediated STAT3-cyclin D1 signaling. A preferable antipsoriatic efficacy was achieved via topical administration of this hydrogel on the IMQ-induced psoriasis mice model, demonstrating the superior transdermal delivery and synergistic enhancement of therapeutic efficacy caused by intrinsic nanoparticles and extrinsic MTX. Conclusion this composite hydrogel could serve as a multifunctional, nonirritating, noninvasive and effective transcutaneous nanoagent against psoriasis.

show abstract

“…They showed that the inhibition of autophagy in hepatocytes increased inflammation cytokines including IL-18 and IL-1 β . However, Yue et al (2019) and Feng et al (2019) showed that the induction of autophagy ameliorates in vitro psoriasis. Our research showed that the ATG5 gene was upregulated in the in vitro cellular psoriatic model.…”

Section: Discussionmentioning

confidence: 99%

The paeonol target gene autophagy-related 5 has a potential therapeutic value in psoriasis treatment

Zhang

Shi

Zhang

et al. 2021

PeerJ

View full text Add to dashboard Cite

Background Paeonol is a potent therapy for psoriasis. This study aimed to screen out paeonol-targeted genes in psoriasis and validate the potential of using paeonol for the management of psoriasis. Methods Microarray datasets were obtained from the Gene Expression Omnibus. The differentially expressed genes (DEGs) in the lesional skin samples and the overlapping genes between DEGs and paeonol- and psoriasis-related genes were defined as potential targets for psoriasis. After being treated with si-ATG5 and pc-ATG5, human HaCaT cells were treated with 100 ng/ml IL-22 and 10 ng/ml TNF-α with and without paeonol. Cell proliferation, apoptosis, and expression of interleukin (IL)-6, IL-1β, Beclin 1, ATG5, and p62 in HaCaT cells were determined using ESLIA, PCR, and Western blot analysis. Results A total of 779 DEGs were identified in the lesional skin samples compared with the non-lesional tissues. The autophagy-related 5 (ATG5) gene was the only gene that overlapped between the DEGs and genes related to paeonol and psoriasis. Cell proliferation, inflammatory cytokines (IL-6 and IL-1β), and ATG5 expression were increased in IL-22/TNF-α-stimulated HaCaT (model) cells compared with control. Paeonol treatment rescued all changes. si-ATG5 transfection increased inflammation and apoptosis in model cells compared with controls. pc-ATG5 prevented IL-22/TNF-α-induced changes in HaCaT cells. Also, si-ATG5 decreased p62 and Beclin 1 proteins, while pc-ATG5 increased them both. Conclusions ATG5-dependent autophagy plays a crucial role in psoriasis. The ATG5 gene might be a therapeutic target for the management of in vitro psoriasis.

show abstract

cis-Khellactone Inhibited the Proinflammatory Macrophages via Promoting Autophagy to Ameliorate Imiquimod-Induced Psoriasis

Cited by 30 publications

References 44 publications

Regulating the Polarization of Macrophages: A Promising Approach to Vascular Dermatosis

Regulating the Polarization of Macrophages: A Promising Approach to Vascular Dermatosis

A Multifunctional Composite Hydrogel as an Intrinsic and Extrinsic Coregulator for Enhanced Therapeutic Efficacy for Psoriasis

The paeonol target gene autophagy-related 5 has a potential therapeutic value in psoriasis treatment

Contact Info

Product

Resources

About