Cis-platinum chemotherapy for ocular basal cell carcinoma.

Abstract

We have used intravenous cis-platinum chemotherapy in the treatment of three patients with basal cell carcinoma of the lid extending into the orbit. Cis-platinum chemotherapy caused a reduction in tumour size and thereby delayed surgery in all cases. It allowed for local resection in one case, appeared to delay a patient's exenteration in a second case, and was used prior to radiotherapy in a third case. While not curative, cis-platinum may be useful as an adjuvant to decrease tumour mass prior to local excision and for patients who refuse or must delay exenteration.

Basal Cell Carcinoma Associated with Orbital Invasion: Clinical Features and Treatment Options

“…Although cisplatinbased therapy may not be curative alone, it may be employed to decrease tumor size before surgery or used as adjuvant therapy in patients who have failed surgery and/or radiation therapy. 27 In conclusion, periocular BCC must be addressed and treated in a timely manner. Inspection of the medial canthi and eyelids should be part of a complete skin examination.…”

Malignant Lesions of the Eyelids

“…If the disease involves the regional lymph nodes, surgery with radiation should be considered. Distant spread is obviously associated with a poor prognosis, but chemotherapeutic treatments are available in these situations 15,16 …”

Cytotoxic effect of a polymer–copper(II) complex containing 2,2′-bipyridyl ligand on human lung cancer cells

“…It is highly effective in treating many cancers (Morley et al, 1991;Go and Adjei, 1999). However, the severe toxic side effects of cisplatin, including nephrotoxicity, neurotoxicity, and emetogenesis, limit the dose of this drug in cancer therapy (Wong and Giandomenico, 1999).…”