Cytotoxic effect of a polymer–copper(II) complex containing 2,2′-bipyridyl ligand on human lung cancer cells

Abstract

The cytotoxic activity of the polymer-copper(II) complex, [Cu(bpy) 2 (BPEI)]Cl 2 Á4H 2 O (bpy = 2,2 0 -bipyridine, BPEI = branched polyethyleneimine) on NCI-H460 human lung cancer cells was determined adopting MTT assay and specific staining techniques. Many of the cultured NCI-H460 cancer cells treated with this complex suffered loss of viability and death mostly through apoptosis and/or necrosis as evidenced by the changes in the nuclear morphology and cytoplasmic features.

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

“…Polyethyleneimine (PEI) is a cationic polymer studied as an alternative to liposomal routes of gene delivery [80]. This polymer acts as chelating agent, has good water solubility, a high number of functional groups and stability [81][82][83][84][85].…”

“…These pcc showed a good antimicrobial activity against some bacteria and fungi, comparable with that of standard drugs ciprofloxacin and clotrimazole, respectively. On the other hand, the systems [Cu(phen) 2 [84,85], besides good antimicrobial activity, exhibited cytotoxicity against human lung cancer cells (NCI-H460). Cytological changes, such as chromatin fragmentation, binucleation, cytoplasmic vacuolation, nuclear swelling, cytoplasmic blebbing as well as late apoptosis and/or necrosis, were also observed during this experiments.…”

Metal-containing and related polymers for biomedical applications

“…The Arunachalam group reported the cytotoxic property of a Cu-containing polymer against human lung cancer cells. 161 The Cu-containing polymer was synthesized from copper ion and 2,2′-bipyridyl ligand and branched polyethyleneimine. It was found that most of the NCI-H460 human lung cancer cells were killed through apoptosis and/or necrosis after treatment with the Cu-containing polymers.…”

TAGUCHİ DENEY TASARIMI KULLANILARAK UÇUCU KÜL İLE Ni (II) GİDERİMİNDE BAZI ADSORPSİYON PARAMETRELERİNİN ETKİNLİĞİNİN İRDELENMESİ

“…Endüstriyel işlemlerde de kullanılan ağır metaller, atık sularında çözünmüş halde bulunur. Atık sulardaki ağır metaller sadece insan sağlığına değil, çevreye de zarar verir [5,6]. Her iki zararın etkisi düşünüldüğünde, arıtma işlemlerinin ne derece önemli olduğu sonucuna varılır.…”