Cisplatin Alters Sodium Excretion and Renal Clearance in Rats: Gender and Drug Dose Related

Abstract

Background:Nephrotoxicity is one of the side effects of cisplatin (CP) therapy which is gender related. CP disturbs renal function through glomerular filtration rate and electrolytes transport disturbances. This study was designed to compare some markers related to renal function in two protocols of CP treatment in rats.Materials and Methods:Male and female rats were subjected to receive single (treat 1; 7.5 mg/kg) and continues doses (treat 2; 3 mg/kg/day for 5 days) of CP, and the measurements were compared with control animals.Results:The serum level of blood urea nitrogen (BUN) and creatinine (Cr), and Cr-clearance, kidney tissue damage score, kidney weight, body weight change, and Na excretion was altered significantly (P < 0.05) in animals treated with continuous dose of CP (treat 2), while alteration of BUN and Cr was gender related. The kidney levels of malondialdehyde and nitrite were significantly different between male and female in two protocols of treatments.Conclusion:Renal function after CP therapy alters in rats’ gender dependently, and it is related to protocol of treatment.

Hepato and Nephrotoxicity Caused by Sub-Chronic Exposure to Relevant Concentrations of Human Exposure to Glyphosate-Based Herbicide: An Experimental Study in Rats

“…The levels of urea and creatinine can also be influenced by gender in humans (Tzamaloukas et al, 1998). A study on the exposure of rats to cisplatin demonstrated that females had higher levels of urea and creatinine than males (Jilanchi et al, 2018). Like other studies, higher levels of AST, ALT, and urea were observed in females exposed to GBH than those in males in this study; however, no gender-based distinctions were observed in the histological parameters (structural damage and NOR numbers).…”

Sinapic acid attenuates cisplatin-induced nephrotoxicity through peroxisome proliferator-activated receptor gamma agonism in rats

“…Several studies indicate that cisplatin accumulation in kidneys results in inflammation, increases lipid peroxidation, and reduces the level of antioxidant, mitochondrial dysfunction, along with deoxyribonucleic acid (DNA) adduct formation and activation of apoptotic pathways. [ 9 ] Moreover, the accumulation of cisplatin is found to be more than five times in kidney as compared to the blood. As a result of which, the concentration of cisplatin in kidney is very high (resulting in toxicity) as compared to the concentration in the blood which is generally nontoxic.…”