Cisplatin-Based Chemotherapy for Merkel Cell Carcinoma of the Skin

Pectasides, Dimitrios; Pectasides, Melina; Psyrri, Amanda; Koumarianou, Anna; Xiros, Nikolaos I.; Pectasides, E.; Gaglia, Asimina; Lianos, Evangelos; Papaxoinis, George; Lampadiari, Vaia; Economopoulos, T.

doi:10.1080/07357900601062354

Cited by 46 publications

(33 citation statements)

References 29 publications

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“…In our study, RT potentiated the effect of systemic CT, and a CR was achieved in 2 patients with locally advanced disease. This is in accordance with other reports that showed the radiosensitivity of MCC [11, 33, 37, 43, 44]. Mortier et al [45] treated some patients only with surgery and some others only with RT with similar outcomes.…”

Section: Discussionsupporting

confidence: 81%

“…In contrast, the role of systemic CT in the treatment of advanced disease is better established [11,32,33,34,37,38,39,40,41]. One of the most studied CT regimens was the combination of a platinum compound, cisplatin or carboplatin, and etoposide.…”

Section: Discussionmentioning

confidence: 99%

“…There are few reports in the literature, with a limited number of patients [3, 13, 27,29,30,31,32,33,34]. The concept of its use was the high rate of response of advanced disease to systemic CT.…”

Section: Discussionmentioning

confidence: 99%

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Merkel Cell Carcinoma of the Skin: A Retrospective Study of 24 Cases by the Hellenic Cooperative Oncology Group

Pectasides

Papaxoinis²,

Pectasides³

et al. 2007

Oncology

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Background: The purpose of this retrospective study was to present the epidemiological and clinical characteristics of 24 patients with Merkel cell carcinoma of the skin (MCC) and their response to various therapeutic modalities. Methods: The tumor registry of the Hellenic Cooperative Oncology Group was used to identify patients with MCC diagnosed between 1986 and 2006. Results: The most frequent primary sites were the extremities (50%), followed by the head (33%) and the trunk (17%). Median time of follow-up was 24 months. Sixteen patients were initially diagnosed with stage I, 5 patients with stage II, and 3 patients with stage III (metastatic) disease. Six patients with stage I disease received adjuvant chemotherapy (CT) and/or radiotherapy (RT). All patients with stage I disease treated only with surgery relapsed, whereas 33% of the patients treated with adjuvant therapy recurred. All patients with stage II disease received adjuvant treatment. Among them, 2 patients relapsed. Disease-free survival (DFS) and overall survival (OS) did not differ significantly between patients with stage I and II disease (stage I: 4-year DFS 27%, 4-year OS 56%; stage II: 4-year DFS 60%, 4-year OS 80%). Patients treated with adjuvant therapy had significantly better DFS than those treated only with surgery (p = 0.012), but OS did not differ significantly (adjuvant group: 4-year DFS 59%, 4-year OS 74%; surgery group: 4-year DFS 10%, 4-year OS 50%). Eleven patients with locally advanced or metastatic disease received CT. The response rate was 73% (complete remission 18%), median progression-free survival was 10 months and median OS was 14 months. Complete remission was achieved in 2 other cases, with the addition of RT after CT. Conclusions: MCC is an aggressive neoplasm with significant chemosensitivity and radiosensitivity, but poor outcome. The role of adjuvant treatment should be further investigated.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Merkel Cell Carcinoma of the Skin: A Retrospective Study of 24 Cases by the Hellenic Cooperative Oncology Group

Pectasides

Papaxoinis²,

Pectasides³

et al. 2007

Oncology

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“…After the response, two patients received RT. The overall median survival was 56 months (range 15-114 months) [26].…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal Merkel Cell Carcinoma without Skin Involvement: Literature Review and One Case Experience

Sota¹,

Vila²,

Giménez³

et al. 2017

Ann Clin Lab Res

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Merkel cell carcinoma (MCC) is an uncommon neuroendocrine tumor that represents a small percentage of skin malignancies, with an aggressive behavior and survival rate at 5 years of 20% to 80%. Among the risk factors, we find Ultraviolet radiation, polyomavirus, other malignancies and immunosuppression.Most of the MCC are diagnosed over 59 years old, being more frequent in men. According to the literature, only 2% to 5% had no skin involvement. Among regions involved, head and neck are the most frequent, followed by limbs and lymph nodes.We described a case of MCC without skin involvement, atypically located in retroperitoneum and given the rarity of both circumstances, we also conducted a review of the reported cases of retroperitoneal MCC without skin tumor.Among retroperitoneal MCC without primary skin involvement, we found 13 reported cases, the average age of these patients was 66 years old, being female only one case. They were all diagnosed by computerized tomography (CT) or Positron emission tomographycomputed tomography (PET-CT). The size of the main mass was variable (15 cm to 3 cm) and selected treatments were chemotherapy, surgery and radiation therapy. Survival rate is unknown in most of them.

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“…Clinical investigators have performed a large number of monotherapies or various combinations of surgery, RT and chemotherapy, but the stage, size and location of the tumours investigated has varied, making retrospective analysis difficult. Therefore, conclusions with regard to these treatment regimens in patients with MCC are controversial (9)(10)(11). It is important to identify the contribution of the treatment regimens.…”

Section: Introductionmentioning

confidence: 99%

Merkel cell carcinoma with lymph node metastasis in the absence of a primary site: Case report and literature review

Zhao

Meng

2012

Oncology Letters

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Abstract. Merkel cell carcinoma (MCC) is a rare malignant skin neoplasm with the potential for local recurrence, spreading to regional lymph nodes (LNs) and distant metastases. Although it has been identified in various anatomical sites, LN metastatic MCC in the absence of a primary site is extremely rare. The present case reports a 54-year-old male who initially underwent histological examination of a biopsy specimen from the right inguinal LNs. A diagnosis of metastatic small cell carcinoma was made. Nine months later, this diagnosis was changed to MCC with multiple metastases following observation of a tumour mass in the right dorsal thigh. Additionally, in the present study a summary is provided of 23 published cases of MCC with initial LN metastasis in the absence of a primary site, with details of clinical characteristics, natural history and pertinent therapy of this uncommon tumour. The present patient with LN metastatic MCC in the absence of a primary site and the other reported cases demonstrate that although multimodal treatment with surgery, radiotherapy (RT) and chemotherapy provides excellent local control, local recurrence and distant metastases commonly develop in this uncommon tumour. LN metastatic MCC in the absence of a primary site is a highly malignant disease and the role of adjuvant postoperative RT and/or chemotherapy remains to be fully determined.

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Cisplatin-Based Chemotherapy for Merkel Cell Carcinoma of the Skin

Cited by 46 publications

References 29 publications

Merkel Cell Carcinoma of the Skin: A Retrospective Study of 24 Cases by the Hellenic Cooperative Oncology Group

Merkel Cell Carcinoma of the Skin: A Retrospective Study of 24 Cases by the Hellenic Cooperative Oncology Group

Retroperitoneal Merkel Cell Carcinoma without Skin Involvement: Literature Review and One Case Experience

Merkel cell carcinoma with lymph node metastasis in the absence of a primary site: Case report and literature review

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