Cissampelos sympodialis Eichl. (Menispermaceae), a medicinal plant, presents antimotility and antidiarrheal activity in vivo

Abstract

BackgroundCissampelos sympodialis (Menispermaceae), known as “Milona” has a specific verified medicinal use for the treatment of diarrhea and respiratory tract diseases. This work aims to evaluate the antimotility and antidiarrheal activity of crude ethanolic extract (EtOHE-Cs), and the total alkaloid fraction (TAF-Cs) obtained from aerial parts of C. sympodialis.MethodsNormal intestinal transit and gastric emptying were used to evaluate antimotility activity. Castor oil-induced diarrhea and castor oil-induced enteropooling were used to evaluate antidiarrheal activity.ResultsThe results indicated that EtOHE-Cs has no antimotility activity, but did demonstrate antidiarrheal activity (at 500 mg/kg), and this activity is related to reduction of intestinal fluid accumulation. The TAF-Cs (at 250 and 500 mg/kg) showed antidiarrheal activity by reducing gastrointestinal motility (gastric emptying and normal intestinal transit).ConclusionsThe antidiarrheal activity of C. sympodialis can be attributed to the chemical compounds already isolated and quantified in this species, mainly alkaloids.

Investigating Potential Modes of Actions of Mimusops kummel Fruit Extract and Solvent Fractions for Their Antidiarrheal Activities in Mice

“…On the contrary, the chloroform fraction had a significant inhibition of intestinal fluid accumulation only at the high dose (400 mg/kg). This further supports the significant activity of these fractions on the number and weight of wet feces on the castor oil induced diarrheal model, which is in agreement with other studies by which the antienteropooling effects of the extract are related to its antidiarrheal effect [40]. In fact, the ability of chloroform fraction to reduce the volume and weight of intestinal contents only at 400 mg/kg ( p < 0.05) lends further support to the limited antidiarrheal effects in the castor oil induced diarrheal model.…”

Evaluation of the antidiarrhoeal activity of 80% methanol extract and solvent fractions of the leaves of <i>Lantana camara</i> linn (Verbenaceae) in mice

“…In the GI enteropooling test, the methanol and aqueous fractions significantly reduced the weight and volume of intestinal fluid at all tested doses when compared to the negative control group. This further supports the significant activity of these fractions on the frequency and weight of wet feces on the castor oil induced diarrheal model, which is in line with other study by which the anti-enteropooling effects of the extract is related with its antidiarrheal effect (de Sales et al, 2015). In fact, the ability of chloroform fraction to reduce the weight of intestinal content only at 400 mg/kg (p<0.05) lends further support to this notion.…”

Preparation of Galla Chinensis Oral Solution as well as Its Stability, Safety, and Antidiarrheal Activity Evaluation

“…Meanwhile, various medicinal plants have been found to have spasmolytic activities, which were due to the blockade of the Ca++ channels [ 40 ], such as Terminalia bellirica [ 39 ], Salvia ballotiflora [ 41 ], and Cissampelos sympodialis Eichl. [ 4 ], and they all have demonstrated antidiarrheal activities. Hence, we considered that GOS might affect gastrointestinal motility like loperamide and atropine through anticholinergic activity, or spasmolytic activity by blocking Ca++ channels in the small intestinal smooth muscle.…”

“…Diarrhea is such a disease that always threatens the health of human beings and many species of animals, especially children under five, and lots of young animals like piglets and newborn (suckling) calves [ 1 – 3 ]. It comes with many typical symptoms, including gastrointestinal motility disorders, soft or liquid stools, increasing frequency of defecation, and abdominal pain [ 4 ]. Diarrhea has many types.…”