Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new anti-inflammatory agents attenuate arachidonate 5-lipoxygenase

Paulose, Silpa Kunnappilly; Chakraborty, Kajal

doi:10.1007/s00044-021-02790-x

Cited by 3 publications

(3 citation statements)

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“…619 The NP chemistry of shell-less molluscs of the genus Onchidium, covering 1978 to 2020, has been reviewed. 620 The muricid gastropod Chicoreus ramosus was the source of benzochromenone 1452, 621 while cuttlesh Sepia pharaonis afforded spiropharanone 1453, 622 the octopus Cistopus indicus yielded the unusual bislactones cistobislactones A 1454 and B 1455, 623 and terpenoids 1456-1458 were isolated from the squid Uroteuthis duvaucelli. 624 Two new saxitoxin analogues, M5hemiaminal 1459 and M6-hemiaminal 1460, were isolated as likely metabolites of paralytic shellsh toxins from the scallop Patinopecten yessoensis.…”

Section: Molluscsmentioning

confidence: 99%

Marine natural products

et al. 2023

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Section: Molluscsmentioning

confidence: 99%

Marine natural products

et al. 2023

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“…[ 213 ] Cistobislactones A ( 236 ) and B ( 237 ), from a marine octopus Cistopus indicus , are two unprecedented sixteen‐membered spiro‐linked macrocylic bislactones showing anti‐inflammatory activities against arachidonate 5‐lipoxygenas. [ 214 ]…”

Section: Hot‐spot Compoundsmentioning

confidence: 99%

Structural and Biological Insights into the Hot‐Spot Marine Natural Products Reported from 2012 to 2021

Zhang

2022

Chin. J. Chem.

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Comprehensive Summary The vast marine ecosystem contains a sea of natural products, which are potential model molecules for new drug development. With more than one thousand new structures been discovered each year, the past decade has become the golden time for marine natural product discovery, leading to a valuable but extra‐large chemical database. Serving as an epitome of the most promising compounds, which take the ultra‐new skeletons and/or excellent bioactivities, this review covers 243 hot‐spot marine natural products reported from 2012 to 2021, to abstract some important chemical and/or biological inspirations for marine natural product study and marine drug development in the future. In addition, some general rules regarding to the source organism, structure‐specialty, organism‐structure specificity, and organism‐bioactivity relationship of these outstanding compounds will also be presented.

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“…The presently studied marine 'old-woman octopus', Cistopus indicus (Rapp [in F erussac & d'Orbigny], 1835) is ubiquitous in the tropical Indian Ocean and South Pacific waters (Dou et al 2020). Earlier literatures reported various pharmacological activities, such as anti-inflammatory, anti-oxidative, anti-hypertensive, and anti-diabetic properties from cephalopoda molluscs (Krishnan and Chakraborty 2019;Krishnan et al 2020), and reports of secondary metabolites including bislactonic macrodiolides from the studied marine octopus (Paulose and Chakraborty 2021;2022) comprehended the importance of the current work. Thus, in continuation with our ongoing search for structurally diverse and biologically active secondary metabolites from C. indicus collected from the Southwestern coast of the Arabian Sea resulted in the identification of two steroidal glycosides cistoindosides A-B from the organic extract by repetitive chromatographic fractionation.…”

Section: Introductionmentioning

confidence: 99%