Citizen petition: Sexual side effects of SSRIs and SNRIs

Healy, David

doi:10.3233/jrs-180745

Cited by 26 publications

(18 citation statements)

References 48 publications

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“…The reduced sensitivity is accompanied by an immediate delay of ejaculation in men and muting of orgasm in both men and women. After a period of treatment, orgasm may stop and there may be a loss of libido (Healy et al ., 2018 a ).…”

Section: Introductionmentioning

confidence: 99%

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Post-SSRI sexual dysfunction & other enduring sexual dysfunctions

Healy

2019

Epidemiol Psychiatr Sci

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Enduring sexual difficulties following treatment with selective serotonin reuptake inhibitor antidepressants have been reported to regulators since 1991, but it was only in 2006 that a formal post-SSRI sexual dysfunction syndrome was reported. The clinical, research and regulatory implications of this syndrome are considerable and researchers using epidemiological methods are well placed to map out the contours of the problem and perhaps pinpoint possible treatments.

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Section: Introductionmentioning

confidence: 99%

“…At present PGAD appears to affect women more than men. This condition seems more likely to happen around the menopause, and while closely related to discontinuation from SSRI medication, can also occur following trauma to the genital area (Healy et al ., 2018 a ).…”

Section: Introductionmentioning

confidence: 99%

Post-SSRI sexual dysfunction & other enduring sexual dysfunctions

Healy

2019

Epidemiol Psychiatr Sci

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“…3,4 PSSD can persist for decades afterward. 2,5 In 2001, persistent genital arousal disorder (PGAD), an enduring disorder of irritable genital sensation, was described. 6 This condition is not linked to enhanced libido and does not stem from psychological issues.…”

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confidence: 99%

Post-SSRI Sexual Dysfunction: A Bioelectric Mechanism?

2020

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Selective serotonin reuptake inhibitor (SSRI) drugs, targeting serotonin transport, are widely used. A puzzling and biomedically important phenomenon concerns the persistent sexual dysfunction following SSRI use seen in some patients. What could be the mechanism of a persistent physiological state brought on by a transient exposure to serotonin transport blockers? In this study, we briefly review the clinical facts concerning this side effect of serotonin reuptake inhibitors and suggest a possible mechanism. Bioelectric circuits (among neural or non-neural cells) could persistently maintain alterations of bioelectric cell properties (resting potential), resulting in long-term changes in electrophysiology and signaling. We present new data revealing this phenomenon in planarian flatworms, in which brief SSRI exposures induce long-lasting changes in resting potential profile. We also briefly review recent data linking neurotransmitter signaling to developmental bioelectrics. Further study of tissue bioelectric memory could enable the design of ionoceutical interventions to counteract side effects of SSRIs and similar drugs.

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“…Immediately on taking a selective serotonin reuptake inhibitor (SSRI), most people have some genital anaesthesia 1. This may be aggravated on withdrawal of the drug and can remain for years after treatment has stopped, constituting post-SSRI sexual dysfunction (PSSD) 2.…”

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confidence: 99%

“…A standard refrain is that randomised clinical trials of short duration and small size have limited ability to detect rare effects of drugs, implying that longer trials are all that’s needed. But as indicated by the sexual effects of SSRIs, which are more common than their mood effects,1 a possibly greater problem lies not in whether we can detect rare adverse events but in our limited ability to detect common ones. Fetishising RCTs as medicine’s only true tool for establishing drug-effect relations may be one reason for this problem.…”

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confidence: 99%