Citrate-Based Biomaterials and Their Applications in Regenerative Engineering

Tran, Richard T.; Yang, Jian; Ameer, Guillermo A.

doi:10.1146/annurev-matsci-070214-020815

Cited by 115 publications

(101 citation statements)

References 148 publications

(151 reference statements)

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“…Soft tissue engineering has previously been limited by the mismatch of the physical, particularly mechanical, properties of commonly used thermoset materials such as PLA, PLGA and PCL with the native extracellular matrix (ECM) [96]. This mechanical mismatch prompts inflammation and scar formation, limiting the integration of the implanted material with the host tissue.…”

Section: Introductionmentioning

confidence: 99%

“…While materials such as these have formed the cornerstone of tissue engineering, a new generation of biomaterial design must take into consideration the native ECM structure towards improving clinical outcomes. Inspired by the three-dimensional crosslinked ECM network, composed of collagen, glycosaminoglycans and elastin, our group has developed a family of citrate-based elastomers (CBEs) capable of mimicking the mechanical properties and structural integrity of ECM [96]. The mechanical properties, functionality and degradation rate of these elastomers can be readily tuned via modulation of the crosslinking degree, allowing them to be adapted for a number of applications including hernia repair.…”

Section: Introductionmentioning

confidence: 99%

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Design strategies and applications of biomaterials and devices for Hernia repair

Kalaba

Gerhard

Winder

et al. 2016

Bioactive Materials

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118

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Hernia repair is one of the most commonly performed surgical procedures worldwide, with a multi-billion dollar global market. Implant design remains a critical challenge for the successful repair and prevention of recurrent hernias, and despite significant progress, there is no ideal mesh for every surgery. This review summarizes the evolution of prostheses design toward successful hernia repair beginning with a description of the anatomy of the disease and the classifications of hernias. Next, the major milestones in implant design are discussed. Commonly encountered complications and strategies to minimize these adverse effects are described, followed by a thorough description of the implant characteristics necessary for successful repair. Finally, available implants are categorized and their advantages and limitations are elucidated, including non-absorbable and absorbable (synthetic and biologically derived) prostheses, composite prostheses, and coated prostheses. This review not only summarizes the state of the art in hernia repair, but also suggests future research directions toward improved hernia repair utilizing novel materials and fabrication methods.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design strategies and applications of biomaterials and devices for Hernia repair

Kalaba

Gerhard

Winder

et al. 2016

Bioactive Materials

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118

128

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“…Citric acid, a Krebs cycle intermediate is the key component used in the citrate methodology, through which various crosslinkable elastomeric polymers can be synthesized by reacting the multifunctional citric acid with different diols and/or amino acids via a facile polycondensation reaction[10–13]. Unlike natural materials (e.g., silk) or traditional synthetic polymers (e.g., poly lactic-co-glycolic acid (PLGA)) that usually have limited tunability for key optical, mechanical, and/or degradation properties, the family of citrate-based biodegradable elastomers possesses tunable mechanical strengths (from tens of Pascal to mega Pascal), programmable degradation rates (from a few days to over a year), reactive nature between citrate-based polymers, multi-functionalities (e.g., adhesive, fluorescent)[14], and as shown in this work, ultrafine tuning of refractive index (~10 −3 )(Figure 1c). Citrate-based elastomers have been used as implant materials for diverse applications such as soft tissue engineering (blood vessel, nerve, and skin)[15–17], bone tissue engineering[18–21], wound healing and bioadhesives[22–26], theranostic nanoparticles for cancer imaging and drug delivery[12,27–33], and biosensing[34].…”

Section: Introductionmentioning

confidence: 99%

Flexible biodegradable citrate-based polymeric step-index optical fiber

et al. 2017

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Implanting fiber optical waveguides into tissue or organs for light delivery and collection is among the most effective ways to overcome the issue of tissue turbidity, a long-standing obstacle for biomedical optical technologies. Here, we report a citrate-based material platform with engineerable opto-mechano-biological properties and demonstrate a new type of biodegradable, biocompatible, and low-loss step-index optical fiber for organ-scale light delivery and collection. By leveraging the rich designability and processibility of citrate-based biodegradable polymers, two exemplary biodegradable elastomers with a fine refractive index difference and yet matched mechanical properties and biodegradation profiles were developed. Furthermore, we developed a two-step fabrication method to fabricate flexible and low-loss (0.4 db/cm) optical fibers, and performed systematic characterizations to study optical, spectroscopic, mechanical, and biodegradable properties. In addition, we demonstrated the proof of concept of image transmission through the citrate-based polymeric optical fibers and conducted in vivo deep tissue light delivery and fluorescence sensing in a Sprague-Dawley (SD) rat, laying the groundwork for realizing future implantable devices for long-term implantation where deep-tissue light delivery, sensing and imaging are desired, such as cell, tissue, and scaffold imaging in regenerative medicine and in vivo optogenetic stimulation.

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“…The monomers chosen play an important role for determining and controlling the functionality, degradability and biocompatibility of the biomaterials to be produced [12]. Many such elastomers based on multifunctional monomers such as citric acid have been reported [6,[11][12][13].…”

mentioning

confidence: 99%

“…Many such elastomers based on multifunctional monomers such as citric acid have been reported [6,[11][12][13]. Investigations on aconitic acid based monomers are comparative less and Kanitkar et al [10] have synthesized and characterized aconitic acid based polyester.…”

mentioning

confidence: 99%

Synthesis, Characterization and Biological Studies of Novel Biodegradable Aconitic Acid Based Copolyester for Application in Skin Tissue Engineering

Kumar¹,

Nanthini²

2018

Asian J. Chem.

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INTRODUCTIONElastomers are long and highly flexible polymer network with cross-linking between them. The high mobility of these polymer chains, which can reconfigure on stress is attributed to the flexible chain length, whereas the elasticity and mechanical strength is attributed to the cross linking. The combinations of these properties make them suitable as biomaterials in medical fields [1]. Aliphatic polyester elastomers can mimic the tissues in our body, as they can be tailored to give a wide range of physiochemical, mechanical and degradative properties [2,3]. So the focus on synthesis, characterization and application of biodegradable polyester elastomers are drastically increasing and they have emerged as a vital class of biomaterials. These elastomers are relatively beneficial as they can be produced at a lower cost with controlled properties.Many such elastomers have been synthesized in the past, such as poly(glycerol sebacate) [4,5] Biodegradable polyester elastomers have gained a greater attention in the field of skin tissue engineering. A series of novel biodegradable polyesters are synthesized, based on non toxic monomers e.g., aconitic acid, citric acid and 1,12-dodoecanediol, which are usually extracted from natural components. In the present work, a co-polyester poly (1,12-dodecanediol acotinate-co-1,12-dodecanediol citrate) (PACDDL) is synthesized by melt poly-condensation without any toxic catalyst. The chemical structure of the elastomers are then characterized by FT-IR, 1 H NMR and 13 C NMR. TGA, DSC techniques. The biological studies such as, in vitro cyto-compatibility, anticancer activity and CAM assay (angiogenesis) are examined. The physical properties exhibit that the elastomer is suitable for application in tissue engineering. The biological studies reveal that the polymer has excellent cell compatibility, making it suitable as potent biomaterial in skin tissue engineering.

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Citrate-Based Biomaterials and Their Applications in Regenerative Engineering

Cited by 115 publications

References 148 publications

Design strategies and applications of biomaterials and devices for Hernia repair

Design strategies and applications of biomaterials and devices for Hernia repair

Flexible biodegradable citrate-based polymeric step-index optical fiber

Synthesis, Characterization and Biological Studies of Novel Biodegradable Aconitic Acid Based Copolyester for Application in Skin Tissue Engineering

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