Citri Reticulatae Pericarpium (Chenpi): Botany, ethnopharmacology, phytochemistry, and pharmacology of a frequently used traditional Chinese medicine

Yu, Xingwen; Sun, Shuang; Guo, Yuan‐ji; Yan, Liu; Yang, Dayu; Li, Guoyu; Lü, Shaowa

doi:10.1016/j.jep.2018.03.031

Cited by 237 publications

(156 citation statements)

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“…The pericarps are peeled and dried under ventilation, making traditional Chinese medicines to treat diseases. They also has a high edible value and a wide range of applications, being used in medicated diet and food therapy (X. Yu et al, ). Modern pharmacology studies indicate that CRP has a wide range of pharmacological antioxidant (Yi, Yu, Liang, & Zeng, ) and anti‐inflammatory effects (Chen, Tait, & Kitts, ), improves the cardiovascular system and regulates lipids in the body (J. Yu, Su, & Lv, ), has a protective effect on the liver (Green, Wheatley, McGrowder, Dilworth, & Asemota, ), suppresses adipogenesis (Sheu, Chuang, & Chien, ) and anti‐lipase activity (Zeng et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…They also has a high edible value and a wide range of applications, being used in medicated diet and food therapy (X. Yu et al, 2018). Modern pharmacology studies indicate that CRP has a wide range of pharmacological antioxidant (Yi, Yu, Liang, & Zeng, 2008) and anti-inflammatory effects (Chen, Tait, & Kitts, 2017), improves the cardiovascular system and regulates lipids in the body (J.…”

Section: Discussionmentioning

confidence: 99%

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Nontargeted urine metabolomics analysis of the protective and therapeutic effects of Citri Reticulatae Chachiensis Pericarpium on high‐fat feed‐induced hyperlipidemia in rats

Zeng

Huang

Luo

et al. 2020

Biomedical Chromatography

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In this study, we focused on studying the changes in urine metabolites in hyperlipidemic rats using ultra‐performance liquid chromatography coupled with quadrupole time‐of‐fight mass spectrometry (UPLC–Q‐TOF/MS) and metabolomics, as well as the effect of Citri Reticulatae Chachiensis Pericarpium (CRCP) on hyperlipidemia. These urine samples were examined by UPLC–Q‐TOF/MS to obtain MS data. The MS data were analyzed by principal component analysis and partial least squares‐discriminant analysis to identify the differential metabolites. CRCP reduced the body weight and levels of triglycerides, total cholesterol and low‐density lipoprotein cholesterol and abnormally decreased high‐density lipoprotein cholesterol in hyperlipidemic rats, which were significantly raised by a high‐fat diet. Twenty‐seven potential biomarkers were identified within the complex sample matrix of urine. Fourteen biomarkers increased in the hyperlipidemia rats compared with normal rats. Meanwhile, 13 biomarkers decreased. CRCP reversed abnormal changes in biomarkers, including 5‐l‐glutamyl‐taurine, 5‐aminopentanoic acid, cis‐4‐octenedioic acid and 2‐octenedioic acid. These biomarkers show that hyperlipidemia is related to the metabolic pathways of taurine and hypotaurine metabolism, fatty acid biosynthesis, and arginine and proline metabolism. CRCP mainly prevents hyperlipidemia by intervening in these metabolic pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nontargeted urine metabolomics analysis of the protective and therapeutic effects of Citri Reticulatae Chachiensis Pericarpium on high‐fat feed‐induced hyperlipidemia in rats

Zeng

Huang

Luo

et al. 2020

Biomedical Chromatography

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“…Citri Reticulatae Pericarpium (CRP), derived from the pericarp of mature fruits of Citrus reticulata Blanco and its cultivars, is an important common Chinese medicinal material . CRP was first documented in Variorum of Shennong's Classic of Materia Medica (Shennong Bencao Jing, ad 200–300) and has been used for the treatment of respiratory and digestive diseases for thousands of years . Owing to its low toxicity and various pharmacological activities, CRP is widely used in traditional medicine and cuisine in China.…”

Section: Introductionmentioning

confidence: 99%

“…In fact, CRP is contained in more than 10% of all formulae in the latest edition of the Chinese Pharmacopoeia (2015 version) . Moreover, it is marketed widely as a dietary ingredient in China and Southeast Asia …”

Section: Introductionmentioning

confidence: 99%

“…1 Moreover, it is marketed widely as a dietary ingredient in China and Southeast Asia. 2,8 Citrus reticulata Blanco comprises various cultivars such as "Chachi", "Ponkan", "Unshiu", "Zhuhong", "Shiyue Ju", etc, and thus lead to multiple origins for CRP. In particular, the pericarp of C. reticulata "Chachi" from Xinhui County (Guangdong Province, China), called "Guangchenpi" (GCP) in Chinese, is traditionally considered to possess superior qualities compared with CRP derived from other cultivars (collectively known as "Chenpi" in Chinese, CP).…”

mentioning

confidence: 99%

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Characterisation and classification of Citri Reticulatae Pericarpium varieties based on UHPLC‐Q‐TOF‐MS/MS combined with multivariate statistical analyses

Zheng

Zeng

Peng

et al. 2018

Phytochemical Analysis

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Introduction Citri Reticulatae Pericarpium (CRP), comprising dried pericarps of Citrus reticulata Blanco and its cultivars, is popularly used for its great medicinal and dietary values. Generally, the pericarps from C. reticulate “Chachi” (“Guangchenpi” in Chinese, GCP) is considered to have superior qualities and merit premium price compared with CRP derived from other cultivars (collectively called “Chenpi” in Chinese, CP). Since its multiple origins and derived economic adulteration, it is significant to systematically compare the chemical profiles of different CRP varieties. Objective The main objective of this work was to identify the chemical profiles of CRP from different varieties and find out potential chemical markers for differentiating GCP and CP. Methods In the present study, a total of 42 CRP samples from 10 varieties (including GCP and CP) were analysed by ultra‐high performance liquid chromatography‐quadrupole‐time‐of‐flight tandem mass spectrometry (UHPLC‐Q‐TOF‐MS/MS) for chemical profiling. Obtained MS/MS data were further employed in multivariate statistical methods to screen the main compounds which contributed to the characterisation and classification of CRP. Results As a result, 73 compounds (mainly flavonoids) were identified or tentatively characterised in these CRP samples. Based on the obtained chemical profiles data, GCP and CP samples could be easily discriminated from each other by statistical analyses. Moreover, seven compounds were selected as having the most discriminating features which contributed to the classification of CRP. Conclusion This work obtains a better understanding of the chemical profiles of different CRP varieties and provides a practical strategy for the authentication of GCP and CP.

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Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

Hou

Guo

et al. 2022

Anim Models and Exp Med

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Inflammation is a common disease involved in the pathogenesis, complications, and sequelae of a large number of related diseases, and therefore considerable research has been directed toward developing anti‐inflammatory drugs for the prevention and treatment of these diseases. Traditional Chinese medicine (TCM) has been used to treat inflammatory and related diseases since ancient times. According to the review of abundant modern scientific researches, it is suggested that TCM exhibit anti‐inflammatory effects at different levels, and via multiple pathways with various targets, and recently a series of in vitro and in vivo anti‐inflammatory models have been developed for anti‐inflammation research in TCM. Currently, the reported classic mechanisms of TCM and experimental models of its anti‐inflammatory effects provide reference points and guidance for further research and development of TCM. Importantly, the research clearly confirms that TCM is now and will continue to be an effective form of treatment for many types of inflammation and inflammation‐related diseases.

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Citri Reticulatae Pericarpium (Chenpi): Botany, ethnopharmacology, phytochemistry, and pharmacology of a frequently used traditional Chinese medicine

Cited by 237 publications

References 60 publications

Nontargeted urine metabolomics analysis of the protective and therapeutic effects of Citri Reticulatae Chachiensis Pericarpium on high‐fat feed‐induced hyperlipidemia in rats

Nontargeted urine metabolomics analysis of the protective and therapeutic effects of Citri Reticulatae Chachiensis Pericarpium on high‐fat feed‐induced hyperlipidemia in rats

Characterisation and classification of Citri Reticulatae Pericarpium varieties based on UHPLC‐Q‐TOF‐MS/MS combined with multivariate statistical analyses

Classic mechanisms and experimental models for the anti‐inflammatory effect of traditional Chinese medicine

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