Citrinin-induced fluidization of the plasma membrane of the fission yeast Schizosaccharomyces pombe

Blaskó, Ágnes; Mike, Nóra; Gróf, Pál; Gazdag, Zoltán; Czibulya, Zsuzsanna; Nagy, Lı́via; Kunsági‐Máté, Sándor; Pesti, Miklós

doi:10.1016/j.fct.2013.07.006

Cited by 10 publications

(5 citation statements)

References 61 publications

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“…The effects of the chemically related ST have not been studied in yeasts in detail although a Saccharomyces strain was susceptible to the mutagenic effect of this toxin . At high concentrations of citrinin, which typically co‐occurs with OTA and is toxic for the fission yeast S. pombe , a direct interaction was suggested between the toxin and the free sulfhydryl groups of plasma membrane proteins, leading to dose‐dependent membrane fluidization . Additionally, citrinin treatment initiated oxidative stress, induced cytotoxic processes with cell cycle arrest and also fragmentation of nuclei.…”

Section: Applications Of Yeastsmentioning

confidence: 99%

Mycotoxins – prevention and decontamination by yeasts

Pfliegler

Pusztahelyi

Pócsi

2015

J. Basic Microbiol.

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The application of yeasts has great potential in reducing the economic damage caused by toxigenic fungi in the agriculture. Some yeasts may act as biocontrol agents inhibiting the growth of filamentous fungi. These species may also gain importance in the preservation of agricultural products and in the reduction of their mycotoxin contamination, yet the extent of mycotoxin production in the presence of biocontrol agents is relatively less understood. The application of yeasts in various technological processes may have a direct inhibitory effect on the toxin production of certain molds, which is independent of their growth suppressing effect. Furthermore, several yeast species are capable of accumulating mycotoxins from agricultural products, thereby effectively decontaminating them. Probiotic yeasts or products containing yeast cell wall are also applied to counteract mycotoxicosis in livestock. Several yeast strains are also able to degrade toxins to less-toxic or even non-toxic substances. This intensively researched field would greatly benefit from a deeper knowledge on the genetic and molecular basis of toxin degradation. Moreover, yeasts and their biotechnologically important enzymes may exhibit sensitivity to certain mycotoxins, thereby mounting a considerable problem for the biotechnological industry. It is noted that yeasts are generally regarded as safe; however, there are reports of toxin degrading species that may cause human fungal infections. The aspects of yeast-mycotoxin relations with a brief consideration of strain improvement strategies and genetic modification for improved detoxifying properties and/or mycotoxin resistance are reviewed here.

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Section: Applications Of Yeastsmentioning

confidence: 99%

Mycotoxins – prevention and decontamination by yeasts

Pfliegler

Pusztahelyi

Pócsi

2015

J. Basic Microbiol.

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“…To date, CIT has been extensively studied for its toxic proper-ties (Blasko et al 2013), including nephrotoxicity, hepatotox-icity (Bennett and Klich 2003, Flajs and Peracia 2009, EFSA, 2012, Shi and Pan 2012, cytotoxicity and genotoxicity (Chang et al 2009). In our study, AEPc, CIT and DIC-A induced cytotoxicity at all concentrations, where these sub-stances increased the number of cells in interphases and reduced the number of dividing cells in A. cepa meristematic cells (Table 2).…”

Section: Cytotoxic and Mutagenic Effects Of Aepc Cit And Dic-ain A Cepamentioning

confidence: 99%

Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum

Filho

Andrade

Lima

et al. 2020

Drug and Chemical Toxicology

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“…27,28 Additionally, citrinin also can produce acute toxicity to fission yeast cells by affecting the plasma membrane. 29 However, there are limited reports about its phytotoxic effects. Several studies indicated that citrinin can inhibit seed germination and seedling growth of Amaranthus hypochondriacus, Echinochloa crus-galli and Picea glehnii, and seedling growth of Allium cepa.…”

Section: Introductionmentioning

confidence: 99%

“…Citrinin can be toxic to animals, 25,26 and it also has antibacterial and antifungal activities 27,28 . Additionally, citrinin also can produce acute toxicity to fission yeast cells by affecting the plasma membrane 29 . However, there are limited reports about its phytotoxic effects.…”

Section: Introductionmentioning

confidence: 99%

Action of the fungal compound citrinin, a bioherbicide candidate, on photosystem II

Yang

Guo

Wang

et al. 2023

Pest Management Science

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BACKGROUNDBioherbicides are becoming more attractive as safe weed control tools towards sustainable agriculture. Natural products constitute an important source chemicals and chemical leads for discovery and development of novel pesticide target sites. Citrinin is a bioactive compound produced by fungi of the genera Penicillium and Aspergillus. However, its physiological‐biochemical mechanism as a phytotoxin remains unclear.RESULTSCitrinin causes visible leaf lesions on Ageratina adenophora similar to those produced by the commercial herbicide bromoxynil. Phytotoxicity bioassay tests using 24 plant species confirmed that citrinin has a broad activity spectrum and therefore has potential as a bioherbicide. Based on chlorophyll fluorescence studies, citrinin mainly blocks PSII electron flow beyond plastoquinone QA at the acceptor side, resulting in the inactivation of PSII reaction centers. Furthermore, molecular modeling of citrinin docking to the A. adenophora D1 protein suggests that it binds to the plastoquinone QB site by a hydrogen bond between the O1 hydroxy oxygen atom of citrinin and the histidine 215 of the D1 protein, the same way as classical phenolic PSII herbicides do. Finally, 32 new citrinin derivatives were designed and sorted according to free energies on the basis of the molecular model of an interaction between the citrinin molecule and the D1 protein. Five of the modeled compounds had much higher ligand binding affinity within the D1 protein compared with lead compound citrinin.CONCLUSIONCitrinin is a novel natural PSII inhibitor that has the potential to be developed into a bioherbicide or utilized as a lead compound for discovery of new derivatives with high herbicidal potency. © 2023 Society of Chemical Industry.

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Citrinin-induced fluidization of the plasma membrane of the fission yeast Schizosaccharomyces pombe

Cited by 10 publications

References 61 publications

Mycotoxins – prevention and decontamination by yeasts

Mycotoxins – prevention and decontamination by yeasts

Cytogenotoxic evaluation of the acetonitrile extract, citrinin and dicitrinin-A from Penicillium citrinum

Action of the fungal compound citrinin, a bioherbicide candidate, on photosystem II

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