Citronellal alleviate macro- and micro-vascular damage in high fat diet / streptozotocin - Induced diabetic rats via a S1P/S1P1 dependent signaling pathway

Qiu, Yue; Chao, Chun-Yan; Jiang, Li; Zhang, Jie; Niu, QianQian; Guo, Yongli; Song, Yuting; Li, Peng; Zhu, Mo‐Li; Yin, Yulong

doi:10.1016/j.ejphar.2022.174796

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…However, as shown in Figure 2 B, the trend of CT and DMBG was consistent, indicating that CT and DMBG had no effect on SNP-induced endothelial−independent relaxation. Secondly, ED is a key factor leading to increased cardiovascular complications in T2DM [ 19 ]. The vasodilation of the mesenteric artery was detected using an in vitro micro-vessel culture monitoring system [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Both DMBG and CT were given to rats by gavage for 15 weeks from the 2nd week. The rats of the five non-control groups were injected intraperitoneally with streptozotocin (STZ, 60 mg/kg in 0.1 M citrate buffer; pH 4.5) to induce a T2DM model at the 13th week [ 19 ]. Finally, fifty rats with blood glucose levels higher than 16.7 mmol/L were considered as T2DM model rats and were included in the follow-up experiment.…”

Section: Methodsmentioning

confidence: 99%

“…According to the method reported in the literature [ 19 , 23 ], the rats were anesthetized with 0.4% pentobarbital sodium (1 mL/100 g) and the mesenteric artery of each rat was dissected. The microvascular relaxation function was evaluated by comparing the relaxation ratio of the top and bottom diameters of the blood vessels in the images collected in the experimental groups.…”

Section: Methodsmentioning

confidence: 99%

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Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus

et al. 2022

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In type 2 diabetes mellitus (T2DM), oxidative stress induces endothelial dysfunction (ED), which is closely related to the formation of atherosclerosis. However, there are few effective drugs to prevent and cure it. Citronellal (CT) is an aromatic active substance extracted from citronella plants. Recently, CT has been shown to prevent ED, but the underlying mechanism remains unclear. The purpose of this study was to investigate whether CT ameliorated T2DM-induced ED by inhibiting the TRPM2/NHE1 signal pathway. Transient receptor potential channel M2 (TRPM2) is a Ca2+-permeable cation channel activated by oxidative stress, which damages endothelial cell barrier function and further leads to ED or atherosclerosis in T2DM. The Na+/H+ exchanger 1 (NHE1), a transmembrane protein, also plays an important role in ED. Whether TRPM2 and NHE1 are involved in the mechanism of CT improving ED in T2DM still needs further study. Through the evaluations of ophthalmoscope, HE and Oil red staining, vascular function, oxidative stress level, and mitochondrial membrane potential evaluation, we observed that CT not only reduced the formation of lipid deposition but also inhibited ED and suppressed oxidative stress-induced mitochondrial damage in vasculature of T2DM rats. The expressions of NHE1 and TRPM2 was up-regulated in the carotid vessels of T2DM rats; NHE1 expression was also upregulated in endothelial cells with overexpression of TRPM2, but CT reversed the up-regulation of NHE1 in vivo and in vitro. In contrast, CT had no inhibitory effect on the expression of NHE1 in TRPM2 knockout mice. Our study show that CT suppressed the expression of NHE1 and TPRM2, alleviated oxidative stress-induced mitochondrial damage, and imposed a protective effect on ED in T2DM rats.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus

et al. 2022

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“…The ease of vascular smooth muscle through prostacyclin (PGI2) since inhibition of its synthesis by indomethacin resulted in a contraction of hypertensive rat models develop low blood pressure (Law and Lo, 2021). The properties of Cymbopogon citratus, being antioxidant and anti-inflammatory, prevent the damage of blood vessels as it increased the level of nitric oxide to support its vasodilation (Qiu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Effect of lemongrass powder on hyperlipidemia compared to Orlistat using experimental animals

Abd-Elrahman

Omar

2023

Egyptian Journal of Nutrition and Health

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This study was designed to investigate the effect of lemongrass powder and Orlistat on hyperlipidemia in rats fed on a high fat diet. Twenty four normal male albino rats of Sprague Dawley Strain weighing (15010g), were used in this study and split into 4 equal groups; each group contained 6 rats.One group was conserved as a control negative group (G1), while (G2) were fed on high fat diet, (G3)were fed on high fat diet plus7.5 % lemongrass powder and (G4) fed on high fat diet plus Orlistat (60 mg /Kg body weight). At the end of the experiment, glucose levels, total protein (Albumin and globulin), serum liver functions, and serum lipids were assessed. The results indicated that tests plants improved glucose levels, liver functions, and lipid profile. According to these results, moderate amounts of lemongrass in our diets could be tried for improvement of hyperlipidemic humans.

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Biomedical Perspectives of Citronellal: Biological Activities, Toxicological Profile and Molecular Mechanisms

Rokonuzzman,

Bhuia,

Al‐Qaaneh

et al. 2024

Chemistry & Biodiversity

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Citronellal, known as rhodinal, is a naturally occurring monoterpenoid aldehyde distinctly found in the distilled oils of Cymbopogon species including C. marginatus, C. citratus, C. validus and C. winterianus family Gramineae. It is also obtained from eucalyptus, mentha, melissa, cinnamomum and allium. It is traditionally used in air freshener, cleaner, floor polishing, deodorants, moisturizing hand/body lotion, perfumes, and adhesives due to its lemon characteristic fragrance and therapeutic benefits. This study aimed to summarize the pharmacological activities and underlying mechanisms of citronellal against different diseases, as well as its toxicological profile. The data was collected from various reliable and authentic literatures by searching different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings imply that citronellal demonstrated several pharmacological effects in various preclinical and pharmacological experimental systems. The results indicated that citronellal demonstrated antioxidant, anti‐inflammatory, antibacterial, antifungal, anthelminthic, and anticancer effects with beneficial effects in neurological and cardiovascular diseases. Our findings also indicated the toxic level of the phytochemical. In conclusion, it has been proposed that citronellal has the capability to serve as a hopeful therapeutic agent, so further extensive clinical research is necessary to develop it as a reliable drug.

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Citronellal alleviate macro- and micro-vascular damage in high fat diet / streptozotocin - Induced diabetic rats via a S1P/S1P1 dependent signaling pathway

Cited by 6 publications

References 62 publications

Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus

Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus

Effect of lemongrass powder on hyperlipidemia compared to Orlistat using experimental animals

Biomedical Perspectives of Citronellal: Biological Activities, Toxicological Profile and Molecular Mechanisms

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