Citrus flavonoids and their antioxidant evaluation

Wang, Yue; Liu, Xiaojuan; Chen, Jiebiao; Cao, Ji; Li, Xian; Sun, Chongde

doi:10.1080/10408398.2020.1870035

Cited by 124 publications

(78 citation statements)

References 201 publications

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“…The intestinal fate, bioavailability, intestinal metabolism, and interaction with the gut microbiota [12] Flavones Sources, antioxidant, anti-inflammatory, antimicrobial, anticancer properties [13] Flavonoids Chemistry, biosynthesis, composition, extraction techniques, health benefits, and industrial applications [14] Composition, antioxidant evaluation, and regulation of Nrf2-Keap1 pathway by citrus flavonoids [15] Role of citrus flavonoids in brain health: evidence from preclinical and human studies [16] Biosynthesis, location, and distribution of flavonoids in citrus plants, factors affecting biosynthesis, and health-promoting properties [17] In vitro, in vivo, and human studies of citrus flavonoids in minimizing the incidence of inflammatory bowel disease [18] Antidiabetic potential of 19 citrus flavonoids, including diosmin, hesperidin, hesperetin, naringin, naringenin, nobiletin, neohesperidin, quercetin, rutin, and tangeretin [19] Therapeutic potential in diabetes and diabetic cardiomyopathy, endothelial dysfunction, atherosclerosis, and platelet function [20] Chemistry, metabolism, bioavailability, biotransformation and delivery systems, and health benefits [6] Hesperidin and vitamin C Antiviral properties against acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [21] Naringenin Antidiabetic properties; in vitro, in vivo, and human studies [22] Combating oxidative stress disorders: cardiovascular disease, diabetes mellitus, neurodegenerative disease, pulmonary disease, cancer, and nephropathy [23] Nobiletin Beneficial effects against Alzheimer's disease (AD) and Parkinson's disease (PD) [24] Nobiletin, 5-demethylnobiletin, and derivatives…”

Section: Essential Oilmentioning

confidence: 99%

Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Saini

Ranjit²,

Sharma³

et al. 2022

Antioxidants

233

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The increased consumption of fruits, vegetables, and whole grains contributes to the reduced risk of many diseases related to metabolic syndrome, including neurodegenerative diseases, cardiovascular disease (CVD), diabetes, and cancer. Citrus, the genus Citrus L., is one of the most important fruit crops, rich in carotenoids, flavonoids, terpenes, limonoids, and many other bioactive compounds of nutritional and nutraceutical value. Moreover, polymethoxylated flavones (PMFs), a unique class of bioactive flavonoids, abundantly occur in citrus fruits. In addition, citrus essential oil, rich in limonoids and terpenes, is an economically important product due to its potent antioxidant, antimicrobial, and flavoring properties. Mechanistic, observational, and intervention studies have demonstrated the health benefits of citrus bioactives in minimizing the risk of metabolic syndrome. This review provides a comprehensive view of the composition of carotenoids, flavonoids, terpenes, and limonoids of citrus fruits and their associated health benefits.

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Section: Essential Oilmentioning

confidence: 99%

Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Saini

Ranjit²,

Sharma³

et al. 2022

Antioxidants

233

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show abstract

“…Citrus fruits are consumed in large quantities worldwide because of their notable nutritional status and bioactives that have health-promoting effects. Citrus fruits contain bioactives such as carotenoids, flavonoids, essential oils, limonoids, and synephrine, which protect from various disorders, including cancer, cardiovascular, digestive, and inflammatory diseases [ 2 , 3 , 4 ]. In addition, citrus fruits possess an important position worldwide because of their ascorbic acid content, dietary fibers, and carbohydrates such as fructose, sucrose, and glucose contents which decrease cholesterol levels and consequently mitigate devastating problems of the digestive system.…”

Section: Introductionmentioning

confidence: 99%

Phytogenic Selenium Nanoparticles Elicited the Physiological, Biochemical, and Antioxidant Defense System Amelioration of Huanglongbing-Infected ‘Kinnow’ Mandarin Plants

et al. 2022

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Citrus greening or huanglongbing (HLB) is commonly known as yellow dragon disease and affects citrus production worldwide. Therefore, it has a significant impact on and deleterious effects in the agro-industrial sector. Significant efforts have been made to combat this disease and mitigate its destructive impact on citrus production, but still, there is no effective biocompatible treatment available to control HLB disorder. This study is considered the first biocompatible approach to evaluate the potential of phytogenic selenium nanoparticles (SeNPs) to improve the health of HLB-infected ‘Kinnow’ mandarin plants. Polymerase chain reactions (PCRs) with specific primers were used to detect HLB disease in ‘Kinnow’ mandarin plants, and PCR products were sequenced to identify Candidatus Liberibacter asiaticus (CLas), and accession numbers for CLas1 and CLas2, MZ851933 and MZ851934, respectively, were obtained. SeNPs were synthesized by using Allium sativum L. clove extract as a reducing, capping, and stabilizing agent and various techniques such as UV-visible spectrophotometry, energy dispersive X-rays, scanning electron microscopy (SEM), Fourier transformed infrared spectroscopy (FTIR), and X-ray diffraction analysis (XRD) were used to confirm the biogenesis of SeNPs. Different concentrations of SeNPs (25, 50, 75, and 100 mg L–1) were exogenously applied to HLB-infected ‘Kinnow’ mandarin plants and obtained spectacular results. The obtained results from the current study proved that 75 mg L–1 of SeNPs was most effective to improve the chlorophyll, carotenoids, relative water content (RWC), membrane stability index (MSI), total soluble sugar (TSS), superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), total flavonoid content (TFC), and total phenolic content (TPC) and significant decrease was observed in hydrogen peroxide (H2O2), malondialdehyde (MDA), and proline (PRO) contents of HLB-infected ‘Kinnow’ mandarin plants as compared to untreated diseased citrus plants. In conclusion, these results allow us to synthesize the SeNPs formulation as a promising management strategy to treat the HLB disease in citrus plants.

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“…Flavonoids are the main active components in the form of either sugar glucoside or free molecules in natural plants. They possess many bio-activities, including lipid-lowering ( Yao et al, 2014 ), antitumor ( Wang et al, 2020 ), anti-oxidation ( Wang et al, 2021 ), and anti-bacterial ( Rasouli et al, 2019 ). Scutellariae Radix in HLJDT contains a large amount of flavonoids, such as quercetin, rutin, baicalin, wogonin, and chrysin ( Yang et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Study on the Molecular Basis of Huanglian Jiedu Decoction Against Atopic Dermatitis Integrating Chemistry, Biochemistry, and Metabolomics Strategies

Jing

Chen

et al. 2021

Front. Pharmacol.

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Atopic dermatitis (AD) is a common chronic relapsing skin inflammation, which severely affect the quality of life of patients. Inhibiting itching and enhancing immunity to mitigate scratching are key elements in the fight against AD. Huanglian Jiedu decoction (HLJDD) has multiple pharmacological effects in the treatment of AD. However, the effective ingredients and underlying molecular mechanisms have not yet been fully explored. Thus, this study integrates chemistry, biochemistry, and metabolomics strategies to evaluate the active substance basis of HLJDD against AD. First, HLJDD was split to five fractions (CPF, 40AEF, 90AEF, PEF and WEF) and 72 chemical components were identified. NSD (Non-similarity degree) among the different fractions showed significant chemical differences (>81%). Interleukin IL-13, IL-17A, IL-3, IL-31, IL-33, IL4, IL-5, TSLP, IgE, and histamine in the serum, and IL-4Rα, JAK1, and HRH4 levels in skin, participating in inhibiting itching and regulating immunity signaling, were found to be restored to varying degrees in AD treating with HLJDD and its fractions, especially 40AEF and CPF. Untargeted metabolomics analysis demonstrated that forty metabolites were differential metabolites in plasma between the HLJDD-treated group and the AD group, involving in histidine metabolism, arginine biosynthesis, pyrimidine metabolism, and so on. Further, targeted metabolomics analysis revealed that eleven differential metabolites, associating with physiological and biochemical indices, were significant improved in the HLJDD and its fractions groups. In conclusion, HLJDD exhibited anti-AD effects by inhibiting itching and enhancing immunity, which in turn regulating the levels of relative metabolites, and CPF and 40AEF were considered the most important components of HLJDD.

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Citrus flavonoids and their antioxidant evaluation

Cited by 124 publications

References 201 publications

Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes

Phytogenic Selenium Nanoparticles Elicited the Physiological, Biochemical, and Antioxidant Defense System Amelioration of Huanglongbing-Infected ‘Kinnow’ Mandarin Plants

Study on the Molecular Basis of Huanglian Jiedu Decoction Against Atopic Dermatitis Integrating Chemistry, Biochemistry, and Metabolomics Strategies

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