Citrus flavonoids collectively dominate the α-amylase and α-glucosidase inhibitions

Sahnoun, Mouna; Trabelsi, Sahar; Béjar, Samír

doi:10.1515/biolog-2017-0091

Cited by 28 publications

(27 citation statements)

References 42 publications

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“…Naringin, as reported by Sahnoun et al (2017), showed an excellent inhibition for α-amylase and α-glucosidase enzyme, with IC 50 values of 8.0 μM and 0.55 μM, respectively. Lim et al (2018) studied the protective effects and molecular mechanisms of naringin in diabetic mice.…”

Section: Naringeninmentioning

confidence: 55%

“…The metabolic effects of hesperidin were also demonstrated by Sahnoun et al (2017) and Zeng et al (2018), who reported its ability to inhibit α-amylase, α-glucosidase, and lipase enzyme with the IC 50 values of 111 and 1 μM, and 688.25 μg/mL, respectively. In a randomized double-blind controlled clinical trial design, 23 subjects with T2DM consumed 500 mg/day hesperidin supplement for 8 weeks.…”

Section: Hesperidinmentioning

confidence: 75%

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Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Section: Naringeninmentioning

confidence: 55%

Section: Hesperidinmentioning

confidence: 75%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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“…Apigenin and phloretin were reported to reversibly inhibit α-glucosidase activity [31,32] . Tangeretin and rhoifolin were found to inhibit α-glucosidase and α-amylase activity [33] . The OGTT test was conducted to evaluate the hypoglycemic potential of these extracts.…”

Section: Resultsmentioning

confidence: 99%

Polyphenol Profile, Antioxidant and Hypoglycemic Activity of Acalypha hispida Leaf Extract

Alfarisi¹,

Diah²,

Wresdiyati³

2020

pharmaceutical-sciences

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“…The results of the present work are in agreement with previous reports on raw citrus samples. Citrus flavonoids have shown carbohydrase inhibition capacity [31]. Citrus × clementina Hort.…”

Section: Bioaccessibility Of Inhibitors Of the Enzymes α-Glucosidase And α-Amylase Composing Citrus Pomacesmentioning

confidence: 99%

In Vitro Bioaccessibility of Bioactive Compounds from Citrus Pomaces and Orange Pomace Biscuits

et al. 2021

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The present investigation aimed to provide novel information on the chemical composition and in vitro bioaccessibility of bioactive compounds from raw citrus pomaces (mandarin varieties Clemenule and Ortanique and orange varieties Navel and Valencia). The effects of the baking process on their bioaccessibility was also assessed. Samples of pomaces and biscuits containing them as an ingredient were digested, mimicking the human enzymatic oral gastrointestinal digestion process, and the composition of the digests were analyzed. UHPLC-MS/MS results of the citrus pomaces flavonoid composition showed nobiletin, hesperidin/neohesperidin, tangeretin, heptamethoxyflavone, tetramethylscutellarein, and naringin/narirutin. The analysis of the digests indicated the bioaccessibility of compounds possessing antioxidant [6.6–11.0 mg GAE/g digest, 65.5–97.1 µmol Trolox Equivalents (TE)/g digest, and 135.5–214.8 µmol TE/g digest for total phenol content (TPC), ABTS, and ORAC-FL methods, respectively; significant reduction (p < 0.05) in Reactive Oxygen Species (ROS) formation under tert-butyl hydroperoxide (1 mM)-induced conditions in IEC-6 and CCD-18Co cells when pre-treated with concentrations 5–25 µg/mL of the digests], anti-inflammatory [significant reduction (p < 0.05) in nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages], and antidiabetic (IC50 3.97–11.42 mg/mL and 58.04–105.68 mg/mL for α-glucosidase and α-amylase inhibition capacities) properties in the citrus pomaces under study. In addition, orange pomace biscuits with the nutrition claims “no-added sugars” and “source of fiber”, as well as those with good sensory quality (6.9–6.7, scale 1–9) and potential health promoting properties, were obtained. In conclusion, the results supported the feasibility of citrus pomace as a natural sustainable source of health-promoting compounds such as flavonoids. Unfractionated orange pomace may be employed as a functional food ingredient for reducing the risk of pathophysiological processes linked to oxidative stress, inflammation, and carbohydrate metabolism, such as diabetes, among others.

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Citrus flavonoids collectively dominate the α-amylase and α-glucosidase inhibitions

Abstract: A series of citrus flavonoids were evaluated for

Cited by 28 publications

References 42 publications

Citrus species: Modern functional food and nutraceutical-based product ingredient

Citrus species: Modern functional food and nutraceutical-based product ingredient

Polyphenol Profile, Antioxidant and Hypoglycemic Activity of Acalypha hispida Leaf Extract

In Vitro Bioaccessibility of Bioactive Compounds from Citrus Pomaces and Orange Pomace Biscuits

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