Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life

Lu, Hanqi; You, Yanting; Zhou, Xinghong; He, Qiuxing; Wang, Ming; Chen, Liqian; Zhou, Lin; Sun, Xiaomin; Liu, Yanyan; Jiang, Pingping; Dai, Jiaojiao; Fu, Xiu‐Qiong; Kwan, Hiu Yee; Zhao, Xiaoshan; Lou, Linjie

doi:10.3389/fimmu.2021.774433

Cited by 21 publications

(10 citation statements)

References 45 publications

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“…72 Furthermore, bacteria like Oscillospira and Prevotella, which showed increased abundance in the HVA and HRA groups, have been associated with beneficial effects on lipid metabolism and liver damage, including the reduction of TC, TG, LDL-C, ALT, and AST levels, as well as the increase of HDL-C levels, which is consistent with our results. 73,74 These findings indicated that the changes observed in the abundance of specific bacterial taxa in our study could potentially contribute to the beneficial effects of VA and RA supplementation on obesity, liver damage, glucose tolerance, insulin resistance, lipid profile, and inflammation in HFD-fed mice.…”

Section: Discussionmentioning

confidence: 56%

Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice

Du,

Lü,

Chen

et al. 2023

J. Agric. Food Chem.

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In this study, blueberry (Vaccinium ssp.) anthocyanins (VA) and blackberry (Rubus L.) anthocyanins (RA) were used to investigate the effects on metabolic syndrome (MetS) and the potential mechanisms. Importantly, all of the data presented in this study were obtained from experiments conducted on mice. As a result, VA and RA reduced body weight gain and fat accumulation while improving liver damage, inflammation, glucose, and lipid metabolism induced by a high-fat diet. Moreover, VA and RA regulated the gut microbiota composition, decreasing the pro-obesity and proinflammation bacteria taxa, such as the phylum Actinobacterium and the genera Allobaculum and Bifidobacterium, and increasing those negatively associated with obesity and inflammation, such as the phylum Bacteroidetes and the genera Prevotella and Oscillospira. Additionally, the supplementation with VA and RA reversed the elevated levels of valeric, caproic, and isovaleric acids observed in the high-fat diet (HFD) group, bringing them closer to the levels observed in the Chow group. This reversal indicated that alterations in the composition and abundance of gut microbiota may contribute to the restoration of short-chain fatty acids (SCFAs) levels. Additionally, PICRUSt2 exhibited that cyanamino acid metabolism and betalain biosynthesis might be the major metabolic pathways in the HVA group compared with the HFD group, while in the HRA group, it was the phosphotransferase system. These findings suggest that VA and RA can ameliorate MetS by modulating the gut microbiota and production of SCFAs.

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Section: Discussionmentioning

confidence: 56%

Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice

Du,

Lü,

Chen

et al. 2023

J. Agric. Food Chem.

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“…Colidextribacter has been reported to produce inosine, which ameliorates acute liver injury and inflammation caused by lipopolysaccharides ( Guo et al, 2021 ). Bilophila , a lipopolysaccharide-producing bacterium, exacerbates HFD-induced inflammation and causes metabolic disturbances in mice ( Lu et al, 2021 ). Low-grade chronic mild inflammation was a feature of obesity, and pathogenic gut microbes stimulate the production and release of LPS from intestinal epithelial cells, which subsequently bind to cytokine receptors and promote the release of pro-inflammatory cytokines ( Musso et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Chen

Huang

et al. 2022

Front. Microbiol.

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Obesity is a metabolic disease associated with gut microbiota and low-grade chronic inflammation. Tremella fuciformis is a medicinal and edible fungus; polysaccharide (TP) is the main active component, which has a variety of biological activities, such as hypoglycemic and hypolipidemic. However, the anti-obesity effects and potential mechanisms of TP have never been reported. This study was conducted to elucidate the inhibitory effect of TP on high-fat diet (HFD)-induced obesity in mice. Mice were split into five groups: normal chow diet (NCD) group, NCD_TP_H group, HFD group, HFD_TP_L group and HFD_TP_H group. Our study showed that TP inhibited high-fat diet-induced weight gain and fat accumulation in mice and reduced blood glucose, hyperlipidemia and inflammation. TP also improved gut microbiota disorders by reducing the Firmicutes/Bacteroidetes ratio and modulating the relative abundance of specific gut microbiota. We also found that the anti-obesity and gut microbiota-modulating effects of TP could be transferred to HFD-fed mice via faecal microbiota transplantation (FMT), confirming that the gut microbiota was one of the targets of TP for obesity inhibition. Further studies showed that TP increased the production of short-chain fatty acids and the secretion of intestinal hormones. Our studies showed that TP inhibited obesity by modulating inflammation and the microbe-gut-brain axis, providing a rationale for developing TP to treat obesity and its complications.

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“…Compared to healthy individuals, the levels of Megamonas in the guts of obese and ASD patients are significantly higher [ 56 , 57 ]. Sutterella is one of the most prevalent Proteobacteria , and its relative abundance was dramatically elevated in obese patients, implying its involvement in the onset and development of obesity [ 58 , 59 ]. In general, we have demonstrated that SFN can improve the composition of human gut microflora by suppressing the growth of pathogenic bacteria, while maintaining the equilibrium of beneficial intestinal flora.…”

Section: Resultsmentioning

confidence: 99%

Simulated Digestion and Fermentation In Vitro by Obese Human Gut Microbiota of Sulforaphane from Broccoli Seeds

Sun

Tang

Hao

et al. 2022

Foods

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Background: sulforaphane is a kind of isothiocyanate, which is obtained by hydrolysis of glucosinolate by the unique myrosinase in plants. It has been proved to prevent the occurrence of many chronic diseases, such as obesity, diabetes and cancer. Objective: The impact of SFN on obese human gut flora, however, has not been established. Methods: In this research, SFN was isolated from broccoli seeds and then refined to achieve 95% purity. Next, an investigation was conducted into the digestion and fermentation processes of SFN. Results: The stability of the SFN in simulated saliva, gastric fluid, and intestinal juice provides evidence that it can reach the gut and be available for utilization by gut microflora. In vitro fermentation of SFN by gut microbes in obese patients results in alteration in constitution of microbiota and production of short chain fatty acids. As the result of SFN ingestion by human gut bacteria, the content of butyric and valeric acids increased 1.21- and 1.46-fold, respectively. In obese human guts, the relative abundances of the beneficial genera including Lactobacillus, Weissella, Leuconosto, Algiphilus and Faecalibacterium significantly increased, whilst the detrimental genera, such as Escherichia-Shigella, Klebsiella, Clostridium_sensu_stricto_1, Sutterella, Megamonas and Proteus drastically declined. Conclusion: Taken together, these findings demonstrate that SFN can be used as a nutraceutical ingredient for obese patients and for improving human health.

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Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life

Cited by 21 publications

References 45 publications

Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice

Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice

Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Simulated Digestion and Fermentation In Vitro by Obese Human Gut Microbiota of Sulforaphane from Broccoli Seeds

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