CLA+ T Cell Response to Microbes in Psoriasis

Jesús‐Gil, Carmen de; Ruiz-Romeu, Ester; Ferrán, Marta; Chiriac, Anca; Deza, Gustavo; Holló, Péter; Santamaria‐Babí, Luis F.

doi:10.3389/fimmu.2018.01488

Cited by 15 publications

(16 citation statements)

References 35 publications

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“…Previously published data from our group showed CLA þ T-celledependent Th17 responses after S. pyogenes activation in vitro in patients with psoriasis (De Jesú s-Gil et al, 2018;Ruiz-Romeu et al, 2016). We found a direct correlation between IgA anti-SE and IL-17F (for plaque psoriasis) or IL-17A (for guttate psoriasis) responses in vitro when CLA þ T cells were cocultured with autologous epidermal cells and activated with SE.…”

Section: S Pyogenes Infection Can Influence Psoriasis Development Ansupporting

confidence: 61%

“…When looking at the distribution of specific IgA1 and IgA2 against S. pyogenes between the different forms of the disease, we observe that both patients with plaque ( Figure 3b) and guttate psoriasis ( Figure 3c) have slightly increased levels of anti-SE IgA1 compared with IgA2. Jesú s-Gil et al, 2018;Norrlind, 1955). Our results showed that IgA against S. pyogenes is present in plasma from patients with plaque and guttate psoriasis and its levels are directly associated to CLA þ T celledependent IL-17 response in our ex vivo model of the disease that correlates with the clinic (Ruiz-Romeu et al, 2018).…”

Section: Patients With Psoriasis Show Elevated Anti-se Iga Compared Wmentioning

confidence: 56%

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Specific IgA and CLA+ T-Cell IL-17 Response to Streptococcus pyogenes in Psoriasis

Jesús‐Gil

Nicolàs

Ruiz-Romeu

et al. 2020

Journal of Investigative Dermatology

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Streptococcus pyogenes tonsillar infection is well known to trigger and exacerbate psoriasis lesions in both guttate and plaque forms of the disease. Although mucosal and cutaneous tissues are closely involved in psoriasis pathology, the interaction between their specific immune responses has not been deeply explored. This work aims to address and characterize the presence of humoral responses against S. pyogenes in patients with psoriasis and its putative association with cytokine responses detected in vitro in our psoriasis ex vivo model, based on the coculture of cutaneous lymphocyte-associated antigen þ/À T cells with autologous epidermal cells. Patients with psoriasis presented increased IgA response to S. pyogenes when compared with control subjects. In patients with plaque psoriasis, despite being negative for anti-streptolysin O antibody titer, IgA plasma levels against S. pyogenes correlated with cutaneous lymphocyte-associated antigen þ T-celledependent IL-17F response in vitro. No association is observed for IgG levels in plaque psoriasis. Similar association is observed for IgA anti-S. pyogenes extract and IL-17A in patients with guttate psoriasis. We propose S. pyogenesespecific IgA as a potential new perspective for better understanding the role of S. pyogenes in psoriasis development.

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Section: S Pyogenes Infection Can Influence Psoriasis Development Ansupporting

confidence: 61%

Section: Patients With Psoriasis Show Elevated Anti-se Iga Compared Wmentioning

confidence: 56%

Specific IgA and CLA+ T-Cell IL-17 Response to Streptococcus pyogenes in Psoriasis

Jesús‐Gil

Nicolàs

Ruiz-Romeu

et al. 2020

Journal of Investigative Dermatology

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“…A decrease in the level of lymphocytes in group C animals may be due to their release from the circulation for the implementation of regulatory protective functions directly in the endothelial tissues, as well as, possibly, in the underlying connective tissue and peripheral immune organs. In particular, it is known that up to 15% of circulating blood cells are CLA-positive T-lymphocytes associated with the cutaneous lymphocyte antigen CLA, which is considered a receptor that controls the affinity of T-lymphocytes for the skin ( Ni and Walcheck, 2009 , De Jesús-Gil et al, 2018 ). It can be assumed that the investigated biomolecules, on the one hand, send CLA-positive T-lymphocytes from the bloodstream to the inflammation focus, and on the other hand, increase the functional activity of lymphocytes and other leukocytes remaining in the blood.…”

Section: Discussionmentioning

confidence: 99%

Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing

Basov

Fedulova

Vasilevskaya

et al. 2021

Saudi Journal of Biological Sciences

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Influence of a new protein-peptide complex on promoting skin wound healing in male BALB/c mice was studied. Protein-peptide complex, extracted from Sus scrofa immune organs, was percutaneously administered using two methods: by lecithin gel-like liquid crystals and by liquid microemulsion. On the fifth day, wound closure in mice with a linear wound model become faster in group (less 2 days comparison to other ones), which was treated with lecithin liquid crystals carrying the protein-peptide complex. This promoting healing can be caused by resorption of bioactive high-molecular compounds the animal skin. In mice with the linear wound model, the tensile strength of the scars were respectively higher both in mice, treated using lecithin liquid crystals with protein-peptide complex, and in mice, treated using microemulsion containing protein-peptide complex, by 215.4% and 161.5% relative to the animals, which did not receive bioactive substances for wound treatment. It was associated with the regeneratory effects of tissue- and species-specific protein-peptide complexes, including α-thymosin Sus scrofa (C3VVV8_PIG, m / z 3802.8) and other factors, which were described as parts of the new extracted complex. This reveals that percutaneous administration of the complex reliably activates local regenerative processes in animals.

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“…Streptococcus pyogenes ( S. pyogenes ) infection is the best characterized clinically relevant trigger of PSO in patients ( 13 ). The molecular mechanism that links S. pyogenes and IL-17 response is starting to be clarified in PSO ( 14 ). Only CLA + memory T cells, but not CLA − , preferentially respond to S. pyogenes in an autologous coculture of T cells and cutaneous epidermal cells from patients with PSO ( 15 ).…”

Section: Psoriasismentioning

confidence: 99%

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

et al. 2021

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Circulating memory T cells are heterogeneous in their tissue tropism. The skin-seeking T cell subset expresses the cutaneous lymphocyte-associated antigen (CLA) on their surface. CLA+ memory T cells not only migrate from blood to skin but also recirculate between blood and skin. Studying CLA+ memory T cells in cutaneous diseases has allowed a better understanding of immune-inflammatory mechanisms that take place. The analysis of the phenotypical features of these cells, their antigen specificity, cytokine production profile, and changes in relationship to clinical status and therapies among other characteristics have led to the concept that they constitute peripheral cellular biomarkers in T cell-mediated cutaneous conditions. CLA+ memory T cells are of relevance in the pathogenesis of several cutaneous diseases, such as psoriasis (PSO), atopic dermatitis, vitiligo, and drug-induced allergic reactions, to name a few. The interaction of circulating CLA+ T cells with skin-resident cells has been investigated in different ex vivo coculture models made out of clinical samples. Interestingly, microbes that are present in the skin or related with human skin diseases are preferentially recognized by CLA+ T cells. Thus, the interaction of Streptococcus pyogenes with CLA+ T cells in PSO is providing novel concepts that help to understand disease immunopathogenesis. The goal of this review is to present latest results in the field of CLA+ T cells in T cell-mediated inflammatory skin diseases and their translational relevance for human immunodermatology.

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CLA+ T Cell Response to Microbes in Psoriasis

Cited by 15 publications

References 35 publications

Specific IgA and CLA+ T-Cell IL-17 Response to Streptococcus pyogenes in Psoriasis

Specific IgA and CLA+ T-Cell IL-17 Response to Streptococcus pyogenes in Psoriasis

Sus Scrofa immune tissues as a new source of bioactive substances for skin wound healing

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

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