Specific IgA and CLA+ T-Cell IL-17 Response to Streptococcus pyogenes in Psoriasis

Jesús‐Gil, Carmen de; Nicolàs, Lídia Sans-de San; Ruiz-Romeu, Ester; Ferrán, Marta; Soria-Martinez, Laura; Chiriac, Anca; Santamaria‐Babí, Luis F.

doi:10.1016/j.jid.2019.12.022

Cited by 22 publications

(18 citation statements)

References 36 publications

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“…titer of immunoglobulin A against S. pyogenes extract (39). We reported that anti-SE IgA values in psoriasis patients (both plaque and guttate forms) are higher than in atopic dermatitis and healthy controls.…”

Section: Plaque Psoriasis: Il-17 Production and Patients Heterogeneitymentioning

confidence: 81%

Human CLA+ Memory T Cell and Cytokines in Psoriasis

et al. 2021

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Psoriasis is a common inflammatory skin condition resulting from the interplay between epidermal keratinocytes and immunological cellular components. This sustained inflammation is essentially driven by pro-inflammatory cytokines with the IL-23/IL-17 axis playing a critical central role, as proved by the clinical efficacy of their blockade in patients. Among all the CD45R0+ memory T cell subsets, those with special tropism for cutaneous tissues are identified by the expression of the Cutaneous Lymphocyte-associated Antigen (CLA) carbohydrate on their surface, that is induced during T cell maturation particularly in the skin-draining lymph nodes. Because of their ability to recirculate between the skin and blood, circulating CLA+ memory T cells reflect the immune abnormalities found in different human cutaneous conditions, such as psoriasis. Based on this premise, studying the effect of different environmental microbial triggers and psoriatic lesional cytokines on CLA+ memory T cells, in the presence of autologous epidermal cells from patients, revealed important IL-17 cytokines responses that are likely to enhance the pro-inflammatory loop underlying the development of psoriatic lesions. The goal of this mini-review is to present latest data regarding cytokines implicated in plaque and guttate psoriasis immunopathogenesis from the prism of CLA+ memory T cells, that are specifically related to the cutaneous immune system.

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Section: Plaque Psoriasis: Il-17 Production and Patients Heterogeneitymentioning

confidence: 81%

Human CLA+ Memory T Cell and Cytokines in Psoriasis

et al. 2021

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“…5 months, Kruskal-Wallis p-value=0.035) compared to the Simulated Remission group. ( Simulated Relapse group: mean = 4.23, standard deviation = 4.17, range = [1, 16] and IQR = [1.75, 6]; Simulated Remission group: mean = 6.45, standard deviation = 4.7, range = [1, 18] and IQR = [3.75, 8.25]. )…”

Section: Resultsmentioning

confidence: 99%

“…Flares During longitudinal follow up [15,10] and during the course of the therapy some patients may experience spontaneous disease exacerbations or flares (i.e., worsening of the symptoms and signs due to undefined environmental/immunological stimuli).…”

Section: Model Personalisationmentioning

confidence: 99%

Individualised computational modelling of immune mediated disease onset, flare and clearance in psoriasis

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Reynolds

et al. 2021

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Despite increased understanding about psoriasis pathophysiology, currently there is a lack of predictive computational models. We developed a personalisable ordinary differential equations model of human epidermis that features two stable steady states: healthy skin and psoriasis. In line with experimental data, an immune stimulus initiated transition from healthy skin to psoriasis and apoptosis induced by UVB phototherapy returned the epidermis back to the healthy state. The flexibility of our model permitted the development of a patient-specific "UVB sensitivity" parameter that enabled accurate simulation of individual patients' clinical response trajectory. In a prospective clinical study of 94 patients, serial individual UVB doses and clinical response (Psoriasis Area Severity Index) values collected over the first three weeks of UVB therapy informed estimation of the "UVB sensitivity" parameter and the prediction of patient outcome at the end of phototherapy. Notably, our model was able to distinguish disease flares and offers the potential for clinical application in early assessment of response to UVB therapy outcome, and for individualised optimisation of phototherapy regimes to improve clinical outcome.

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“…Only CLA + memory T cells, but not CLA − , preferentially respond to S. pyogenes in an autologous coculture of T cells and cutaneous epidermal cells from patients with PSO (15). Besides, patients with PSO who are negative for antistreptolysin O (ASO) antibody present increases levels of immunoglobulin (Ig) A, but not IgG, to S. pyogenes, which are directly associated with CLA + T-cell-dependent IL-17 response to S. pyogenes in vitro (16). These results suggest that increased exposure to S. pyogenes, as demonstrated by the presence of specific humoral immune response even in patients with ASO negative, upon recognition by CLA + T cells can fuel pathogenic IL-17 production.…”

Section: Psoriasismentioning

confidence: 99%

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

et al. 2021

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Circulating memory T cells are heterogeneous in their tissue tropism. The skin-seeking T cell subset expresses the cutaneous lymphocyte-associated antigen (CLA) on their surface. CLA+ memory T cells not only migrate from blood to skin but also recirculate between blood and skin. Studying CLA+ memory T cells in cutaneous diseases has allowed a better understanding of immune-inflammatory mechanisms that take place. The analysis of the phenotypical features of these cells, their antigen specificity, cytokine production profile, and changes in relationship to clinical status and therapies among other characteristics have led to the concept that they constitute peripheral cellular biomarkers in T cell-mediated cutaneous conditions. CLA+ memory T cells are of relevance in the pathogenesis of several cutaneous diseases, such as psoriasis (PSO), atopic dermatitis, vitiligo, and drug-induced allergic reactions, to name a few. The interaction of circulating CLA+ T cells with skin-resident cells has been investigated in different ex vivo coculture models made out of clinical samples. Interestingly, microbes that are present in the skin or related with human skin diseases are preferentially recognized by CLA+ T cells. Thus, the interaction of Streptococcus pyogenes with CLA+ T cells in PSO is providing novel concepts that help to understand disease immunopathogenesis. The goal of this review is to present latest results in the field of CLA+ T cells in T cell-mediated inflammatory skin diseases and their translational relevance for human immunodermatology.

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Specific IgA and CLA+ T-Cell IL-17 Response to Streptococcus pyogenes in Psoriasis

Cited by 22 publications

References 36 publications

Human CLA+ Memory T Cell and Cytokines in Psoriasis

Human CLA+ Memory T Cell and Cytokines in Psoriasis

Individualised computational modelling of immune mediated disease onset, flare and clearance in psoriasis

The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders

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