Human CLA+ Memory T Cell and Cytokines in Psoriasis

Abstract

Psoriasis is a common inflammatory skin condition resulting from the interplay between epidermal keratinocytes and immunological cellular components. This sustained inflammation is essentially driven by pro-inflammatory cytokines with the IL-23/IL-17 axis playing a critical central role, as proved by the clinical efficacy of their blockade in patients. Among all the CD45R0+ memory T cell subsets, those with special tropism for cutaneous tissues are identified by the expression of the Cutaneous Lymphocyte-associated Antigen (CLA) carbohydrate on their surface, that is induced during T cell maturation particularly in the skin-draining lymph nodes. Because of their ability to recirculate between the skin and blood, circulating CLA+ memory T cells reflect the immune abnormalities found in different human cutaneous conditions, such as psoriasis. Based on this premise, studying the effect of different environmental microbial triggers and psoriatic lesional cytokines on CLA+ memory T cells, in the presence of autologous epidermal cells from patients, revealed important IL-17 cytokines responses that are likely to enhance the pro-inflammatory loop underlying the development of psoriatic lesions. The goal of this mini-review is to present latest data regarding cytokines implicated in plaque and guttate psoriasis immunopathogenesis from the prism of CLA+ memory T cells, that are specifically related to the cutaneous immune system.

T‐cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin‐focused, allergen‐driven disease

“…41,42 A potential factor that might influence the results reported here is possible recirculation of T cells from the skin back into the blood. This concept of recirculation has been postulated several times [43][44][45] based on observations from clinical trials with LFA-1 antibodies to block skin infiltration. 46,47 These studies observed accumulating and bona fide recirculating T cells in the blood, which were CLA + .…”

Single-cell transcriptomic landscape of immunometabolism reveals intervention candidates of ascorbate and aldarate metabolism, fatty-acid degradation and PUFA metabolism of T-cell subsets in healthy controls, psoriasis and psoriatic arthritis

“…It is known that CLA, encoded by gene SELPLG , positive memory T cells distribute in a large number in psoriatic lesions, and CLA is the molecular basis for mediating cell chemotaxis to skin lesions ( 17 , 18 ). In order to explore the ideal metabolic intervention of immunometabolism reprogramming of PSO, we performed analysis at the level of Cluster_T cells and skin-homing subfractions CLA+T cells, focused on subset of CD4+ TCMs, CD8+ TEMs, Tregs, MAITs, and γδ T cells.…”

Gender-related differences in the effects of Inonotus obliquus polysaccharide on intestinal microorganisms in SD rats model

“…In male rats, polysaccharide-degrading bacteria were mainly dominated by Bacteroidia , such as Muribaculaceae ( 64 ), which could increase the expression of AhRR in intestinal immune cells as well as Bacteroides which could synthesize conjugated linoleic acid (CLA). The latter can regulate immune functions, lower blood lipids and exert anti-diabetic as well as anti-inflammatory effects ( 65 , 66 ).Through comparative analysis examining how dominant bacteria varied between sexes after consuming IOP, it was found that IOP could improve the activity of dominant bacteria in intestinal microbes, and these results could form the basis of a future approach whereby bacterial species are selected based on sex-related differences to reshape the intestinal microenvironment, while providing ideas for metabolic analysis.…”