Cladieunicellin H, a New Hemiketal Eunicellin-Based Diterpenoid from the Octocoral Cladiella sp

Abstract

A new hemiketal eunicellin-based diterpenoid, cladieunicellin H (1), was isolated from an Indonesian octocoral identified as Cladiella sp. The structure of 1 was determined by spectroscopic methods. This compound was found to display moderate inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

Cladiella Octocorals: Enormous Sources of Secondary Metabolites with Diverse Structural and Biological Properties

“…specimen yield two new 6-hydroxyeunicellin diterpenoids, namely cladieunicellin G (138) and 6-epi-cladieunicellin F (139), [53] and a new hemiketal eunicellin-type diterpenoid, namely cladieunicellin H (140). [54] Structurally, 6-hydroxyeunicellin 139 was an epimer of 136. Biologically, 139 displayed significant inhibitory activity against superoxide anion production (IC 50 6.57 � 0.85 μg/mL) by human neutrophils.…”

“…Continuous systematic chemical investigation on this Indonesian octocoral Cladiella sp. specimen yield two new 6‐hydroxyeunicellin diterpenoids, namely cladieunicellin G ( 138 ) and 6‐ epi ‐cladieunicellin F ( 139 ), [53] and a new hemiketal eunicellin‐type diterpenoid, namely cladieunicellin H ( 140 ) [54] . Structurally, 6‐hydroxyeunicellin 139 was an epimer of 136 .…”

Discovery of New Eunicellin-Based Diterpenoids from a Formosan Soft Coral Cladiella sp.

“…In our continuing research on the chemical constituents of octocorals belonging to the genus Cladiella (family Alcyoniidae) collected off the waters of Taiwan and Indonesia, a series of interesting eunicellin-related diterpenoids (2,11-cyclized cembranoid) were isolated [ 1 , 2 , 3 , 4 , 5 , 6 ] and the compounds of this type were proven to possess various bioactivities [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Recently, our chemical examination on an octocoral identified as Cladiella sp.…”

Cladieunicellins K and L, New Eunicellin-Based Diterpenoids from an Octocoral Cladiella sp.

“…Eunicellin-based diterpenoids, such as eleutherobin, have been proven to be potential anticancer agents [ 1 ]. In our continuing research on the chemical constituents of octocorals belonging to the genus Cladiella collected off the waters of Taiwan and Indonesia, various eunicellin-related analogues have been isolated [ 2 – 7 ]. Recently, two new eunicellin-type diterpenoids, cladieunicellins K ( 1 ) and L ( 2 ) were isolated from an octocoral identified as Cladiella sp.…”