Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.

Cladielloides C and D: Novel Eunicellin-Based Diterpenoids from an Indonesian Octocoral Cladiella sp. -New compounds, cladielloides C (I) and D (II), display moderate inhibitory effects on superoxide anion generation by human neutrophils. Additionally, cladielloide C exhibits significant cytotoxicity towards CCRF-CEM tumor cells. -(TAI, C.-Y.; CHEN, Y.-H.; HWANG, T.-L.; FANG, L.-S.; WANG, W.-H.; LIU, M.-C.; SU, J.-H.; WU, Y.-C.; SUNG*, P.-J.; Bull. Chem. Soc. Jpn. 84 (2011) 5, 531-536, http://dx.doi.org/10.1246/bcsj.20100348 ; Grad. Inst. Mar. Biotechnol., Natl. Dong Hwa Univ., Pingtung 944, Taiwan; Eng.) -C. Cyrus 36-182

A new hemiketal eunicellin-based diterpenoid, cladieunicellin H (1), was isolated from an Indonesian octocoral identified as Cladiella sp. The structure of 1 was determined by spectroscopic methods. This compound was found to display moderate inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.