Cladosins A–E, Hybrid Polyketides from a Deep-Sea-Derived Fungus, <i>Cladosporium sphaerospermum</i>

Wu, Guangwei; Sun, Xinhua; Yu, Ge; Wang, Wei; Zhu, Tianjiao; Gu, Qianqun; Li, Dehai

doi:10.1021/np400833x

Cited by 77 publications

(59 citation statements)

References 43 publications

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“…In addition, all seaweed derived isolates identified in this study are facultative marine fungi and can be found in marine and terrestrial ecosystems. For instance, C. sphaerospermum [61], C. ramotenellum [62], P. brevicompactum [63], E. nigrum [62], C. rosea [64], and R. oryzae [65] are mainly known from terrestrial environments, but they are also found in deep sea (C. sphaerospermum) [66], Dead Sea water (C. ramotenellum, P. brevicompactum) [67], river sediments (C. rosea) [68], associated with marine sponges (E. nigrum, P. brevicompactum) [69,70], bryozoan Bugula sp. (R. oryzae) [71] or with seagrasses Posidonia oceanica (C. rosea) [72].…”

Section: Discussionmentioning

confidence: 99%

Macroalgae Derived Fungi Have High Abilities to Degrade Algal Polymers

et al. 2019

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Marine fungi associated with macroalgae are an ecologically important group that have a strong potential for industrial applications. In this study, twenty-two marine fungi isolated from the brown seaweed Fucus sp. were examined for their abilities to produce algal and plant biomass degrading enzymes. Growth of these isolates on brown and green algal biomass revealed a good growth, but no preference for any specific algae. Based on the analysis of enzymatic activities, macroalgae derived fungi were able to produce algae specific and (hemi-)cellulose degrading enzymes both on algal and plant biomass. However, the production of algae specific activities was lower than the production of cellulases and xylanases. These data revealed the presence of different enzymatic approaches for the degradation of algal biomass by macroalgae derived fungi. In addition, the results of the present study indicate our poor understanding of the enzymes involved in algal biomass degradation and the mechanisms of algal carbon source utilization by marine derived fungi.

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Section: Discussionmentioning

confidence: 99%

Macroalgae Derived Fungi Have High Abilities to Degrade Algal Polymers

et al. 2019

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“…The differences in the 1 H NMR data between the (S)-and (R)-di-MTPA derivatives were calculated as Δδ S−R values. In previous studies, the absolute configuration of acyclic syn 1,3-diols from di-MTPA esters was determined by considering three distinct Δδ values on the left (Δδ L ), center (Δδ C ), and right (Δδ R ) sides of the di-MTPA esters [28,29]. As shown in ▶ Fig.…”

Section: Resultsmentioning

confidence: 99%

Diarylheptanoids from Curcuma phaeocaulis Suppress IL-6-Induced STAT3 Activation

et al. 2018

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Three undescribed diarylheptanoids (3: -5: ) and six known curcuminoids (1, 2: , and 6: -9: ) were obtained from the ethyl acetate-soluble fraction of an ethanolic extract of . Their chemical structures and absolute configurations were elucidated by high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, circular dichroism spectroscopy, and the modified Mosher's method. Previous studies constructed Hep3B cells stably transfected with pSTAT3-Luc plasmid containing STAT3 binding site to discover STAT3 inhibitors from natural products. The STAT3 inhibitory activities of all isolates were measured in transfected Hep3B cells after treatment with IL-6. Compound 5: ((5)-1,7-Bis(3,4-dimethoxyphenyl)-3-methoxy-1-hepten-5-ol), demethoxycurcumin (7: ), and curcumin (8: ) exhibited significant inhibitory activity (IC values: 11.1, 1.9, and 1.6 µM, respectively). Furthermore, IL-6-induced phosphorylation of STAT3, and the mRNA expression levels of inflammation-related genes such as CRP, IL-1β, ICAM-1, and SOCS3 were significantly reduced by exposure to compound 5: . These data suggested that the inhibitory activity of 5: is associated with the suppression of STAT3 phosphorylation. Thus, compound 5: may be a promising candidate for the treatment of cancer or inflammatory diseases related to the IL-6/STAT3 signaling pathway.

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“…Ten cladosins (A-D, and F-K) (254-263), a series of C-3-imine-TA analogues, were found in deep-sea-derived C. sphaerospermum. Cladosins 254-257 were discovered from deep-sea-derived C. sphaerospermum 2005-01-E3 cultured with a rice-based medium [199]. Following the OSMAC method, cladosins F-G (258-259) were isolated from the soybean-based medium fermentation of this strain [200].…”

Section: Summary Of Tetramic Acid Products From Marine Microbesmentioning

confidence: 99%

The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms

Jiang

Chen

et al. 2020

Marine Drugs

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Tetramic acid (pyrrolidine-2,4-dione) compounds, isolated from a variety of marine and terrestrial organisms, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities. In the past decade, marine-derived microorganisms have become great repositories of novel tetramic acids. Here, we discuss the biological activities of 277 tetramic acids of eight classifications (simple 3-acyl tetramic acids, 3-oligoenoyltetramic acids, 3-decalinoyltetramic acid, 3-spirotetramic acids, macrocyclic tetramic acids, N-acylated tetramic acids, α-cyclopiazonic acid-type tetramic acids, and other tetramic acids) from marine-derived microbes, including fungi, actinobacteria, bacteria, and cyanobacteria, as reported in 195 research studies up to 2019.

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Cladosins A–E, Hybrid Polyketides from a Deep-Sea-Derived Fungus, Cladosporium sphaerospermum

Cited by 77 publications

References 43 publications

Macroalgae Derived Fungi Have High Abilities to Degrade Algal Polymers

Macroalgae Derived Fungi Have High Abilities to Degrade Algal Polymers

Diarylheptanoids from Curcuma phaeocaulis Suppress IL-6-Induced STAT3 Activation

The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms

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