Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement

The isolation and characterization of putative mesenchymal stem cells from the spiny mouse

“…Similarly, isolated MSCs can be directed to differentiate in vitro, by culture with lineage specific differentiation medium, to differentiate down the osteogenic, adipogenic and chondrogenic lineages (Gregory et al 2005). The fibroblast-like cells isolated from the spiny mice in this study exhibited multilineage differentiation potential with the capacity for adipogenic, chondrogenic and osteogenic differentiation, as demonstrated for MSCs isolated from other species (Bosnakovski et al 2006;Horwitz et al 2005;Izadpanah et al 2005;Eslaminejad et al 2006;Tuli et al 2003).…”

“…A defining property of MSCs is their ability to undergo adipogenic, osteogenic and chondrogenic differentiation (Horwitz et al 2005;Alison and Islam 2009). As a part of characterizing the putative spiny mouse MSCs, it was therefore necessary to assess their tri-lineage differentiation potential.…”

Adult stem cells: potential implications for perioperative medicine

“…Par conséquent, étant donné qu'elles ne présentent pas les caractéristiques de cellules souches prototypiques, on a suggéré l'utilisation du terme « cellule stromale » pour décrire les CSM. 3 À l'origine, les CSM étaient isolées à partir de moelle osseuse adulte (dans laquelle on pense qu'elles soutiennent l'hématopoïèse), de tissu adipeux et de gelée de Wharton tirés de cordons ombilicaux. Ces sources sont, encore aujourd'hui, les mieux caractérisées; toutefois, les CSM sont désormais considérées comme des cellules omniprésentes dans littéralement tous les tissus étudiés.…”

“…Thus, it has been suggested that the term, ''stromal cell'', be applied to MSCs as they do not display prototypical stem cell characteristics. 3 Initially, MSCs were isolated from adult bone marrow (where they are believed to support hematopoiesis) as well as adipose tissue and Wharton's jelly from umbilical cords. These sources remain the best characterized; however, MSCs are now regarded to be ubiquitous cells found in virtually every tissue studied.…”

Mesenchymal stromal cells: more than inhibitory cells

“…Mesenchymal stem cells, 1 cautiously re-named recently multipotent mesenchymal stromal cells (MSCs) 2 because of their heterogeneous multipotency at single cell level and their similarities with fibroblasts, 3 have been strongly suggested in the last decade as powerful inhibitory cells for the vast majority of immune effector cells. The redundancy of the molecular pathways involved in the immune modulation suggests that this property, shared by MSCs of different tissue origin, 4 including lymphoid organs, 5,6 and by fibroblasts 3,7 has a pivotal role in tissue homeostasis in normal and pathological inflammatory reactions.…”