Clarithromycin‐Carbamazepine Interaction: A Case Report

Albani, Fiorenzo; Riva, R.; Baruzzi, Agostino

doi:10.1111/j.1528-1157.1993.tb02391.x

Cited by 51 publications

(5 citation statements)

References 8 publications

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“…Concomitant administration of clarithromycin, josamycin, miocamycin or flurithromycin to volunteers has been shown to significantly alter the pharmacokinetic profile of carbamazepine (Periti et al, 1992). In a case report, a 10-day course of clarithromycin led to increased serum carbamazepine concentrations, despite a dosage reduction of carbamazepine (Albani, Riva & Baruzzi, 1993).…”

Section: Carbamazepinementioning

confidence: 97%

Drug interactions with azithromycin and the macrolides: an overview

Nahata¹

1996

Journal of Antimicrobial Chemotherapy

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Evidence interactions between individual macrolides and a number of pharmacologically active compounds that are frequently co-administered to patients with bacterial infections is reviewed. Theophylline is strongly associated with erythromycin interaction; clarithromycin may also interact with this drug. Azithromycin, spiramycin and rokitamycin, however, do not appear to have any effect on theophylline pharmacokinetics. The other therapeutic agents considered are cyclosporin, the antiepileptics, carbamazepine and phenytoin, terfenadine, warfarin, oral contraceptives, agents used in the management of gastritis and peptic ulcer and zidovudine. With the exception of interaction with antacids, there is no evidence that azithromycin, unlike most other macrolides, interacts with any of these agents to produce clinically significant adverse effects. The explanation for this variation appears to be azithromycin's inability to induce and bind to the cytochrome P450 IIIA enzyme system.

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Section: Carbamazepinementioning

confidence: 97%

Drug interactions with azithromycin and the macrolides: an overview

Nahata¹

1996

Journal of Antimicrobial Chemotherapy

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“…Among antibiotics used in children, clarithromycin, chloramphenicol, doxycycline, erythromycin, isoniazid and metronidazole are moderate or strong CYP3A4 inhibitors and CBZ is metabolized mainly by this cytochrome. There are several clinical studies and case reports that show that treatment with one of these antibiotics may cause an increase in CBZ blood levels, that may be even doubled, as reported with erythromycin [66] and clarithromycin [67] with consequent drug toxicity. This DDI is very frequent and often serious because CBZ is widely used, is metabolized almost only by CYP3A4 and exhibits dose-dependent adverse effects (diplopia, ataxia, dizziness) and a narrow therapeutic win-dow.…”

Section: )mentioning

confidence: 99%

A review of pharmacokinetic drug interactions between antimicrobial and antiseizure medications in children

Zaccara

Lattanzi

2021

Epileptic Disorders

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Comorbidity between epilepsy and infectious diseases in children is frequent. Pharmacokinetic drug-drug interactions (DDIs) between antiseizure medications (ASMs) and anti-infectives can occur and influence their efficacy or cause toxicity. All potential DDIs between ASMs and antimicrobial agents used in children were identified through consultation of drug compendia. Clinical studies, case reports and summaries of product characteristics of all identified drugs were also searched. A typical example of a DDI that is often observed in children is that involving valproate (VPA) and carbapenem antibiotics. This DDI has a unique mechanism of action (inhibits the enzyme that catalyses the hydrolysis of VPA-glucuronide) and leads to a fall of around 60% of VPA level, associated with seizure recurrence. An example of bidirectional DDI involves the antimycotic voriconzole and several ASMs. Voriconazole is metabolized and is a strong inhibitor of cytochrome (CYP)3A4, CYP2C9/10 and CYP2C19. There is clinical evidence of induction of voriconazole metabolism with possible loss of its efficacy by phenytoin (PHT), while voriconazole increases the levels of PHT. Other ASMs that are inducers of these enzymes, such as carbamazepine (CBZ), phenobarbital, stiripentol and to a lesser degree, oxcarbazepine, might be predicted to decrease the level of voriconazole. Voriconazole might also be predicted to increase levels of cannabidiol, CBZ, lacosamide, midazolam, and zonisamide. DDIs between ASMs and some antiviral agents are potentially even more frequent and clinically relevant.

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“…Brought to you by | Stockholms Universitet Authenticated Download Date | 7/7/15 1:34 PM S53 erythromycin, and chlorethromycine (biaxin) may lead to an increase of CBZ levels (9).…”

Section: International Journal Of Adolescent Medicine and Healthmentioning

confidence: 99%

Antiepileptic drug (AED) treatment for epilepsy in adolescence

Riviello¹

2000

International Journal of Adolescent Medicine and Health

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The prevention of recurrent seizures is the goal of epilepsy therapy and antiepileptic drugs (AED) remain the cornerstone of treatment. Advances in the treatment of epilepsy include the introduction of many new AEDs (1), identification of the basic mechanisms of epilepsy and the mechanisms of action of the AEDs (2), and new surgical treatments, such as the vagal nerve stimulator. Uncontrolled seizure activity may result in medical, developmental, and psychological disturbances, which can remit if control is achieved. This is especially so in adolescence, when seizure activity can be especially disruptive and interfere with routine daily activities, especially driving. In addition, the various AEDs may cause unwanted side effects, which interfere with treatment, and if persistent, may lead to the discontinuation of treatment. In those with medically intractable seizures, epilepsy surgery or VNS could be an option.This presentation reviews the AEDs used in epilepsy, especially the newer AEDs, and clinical situations peculiar to the female adolescent. The issue of compliance with treatment is frequent in this age group, and made more difficult, if unwanted side effects occur. Knowledge about the use of AEDs is therefore important in preventing side effects.

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Clarithromycin‐Carbamazepine Interaction: A Case Report

Cited by 51 publications

References 8 publications

Drug interactions with azithromycin and the macrolides: an overview

Drug interactions with azithromycin and the macrolides: an overview

A review of pharmacokinetic drug interactions between antimicrobial and antiseizure medications in children

Antiepileptic drug (AED) treatment for epilepsy in adolescence

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