Clarithromycin Extended-Release Tablet

Darkes, Malcolm J.M.; Perry, Caroline M.

doi:10.1007/bf03256648

Cited by 23 publications

(2 citation statements)

References 101 publications

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“…A minimum hardness of approximately 4-6 kg/cm2 is thought to be necessary for mechanical stability for uncoated tablets. [14] Thickness Five tablets were taken from each formulation batch, and measured their diameter with a vernier calliper and a screw gauge was used to measure the tablet thicknesses. A calculation was made to determine the average thickness.…”

Section: Post Compression Evaluation Of Bilayered Tablets Physical Ap...mentioning

confidence: 99%

Formulation and evaluation of floating bilayer tablet of Aceclofenac and Esomeprazole

2024

IJFMR

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The development of bilayer floating tablets containing esomeprazole and aceclofenac was the objective of this study. OTC analgesics, like NSAIDs, are extensively used, but they are frequently abused and may be harmful, and users are often unaware of the possibility of adverse effects. It consists of an instant release aceclofenac layer and a floating sustained release esomeprazole layer manufactured using the wet granulation method. Aceclofenac was included into five immediate release layer formulations (F1–F5) made with sodium starch glycolate super disintegrants. To create five formulations of sustained release layer containing Esomeprazole (F1-F5), synthetic release retarding polymers (HPMC E15) were combined with other ingredients. The immediate release formulation (F3) released 97 % of the Aceclofenac in 1 hours, and the sustained release formulation (F5) released 96 % of the esomeprazole in 10 hours. There was an inverse relationship between the amount of polymer present and the amount of drug released. There were no chemical interactions between the drug and the polymers used, according to an FTIR analysis. 10% to 20 percent of patients who take nonsteroidal anti-inflammatory medicines (NSAIDs) develop stomach ulcers. This bilayer floating tablet containing aceclofenac and esomeprazole is useful for managing pain and inflammation in addition to NSAID-induced ulcer.

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Section: Post Compression Evaluation Of Bilayered Tablets Physical Ap...mentioning

confidence: 99%

Formulation and evaluation of floating bilayer tablet of Aceclofenac and Esomeprazole

2024

IJFMR

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“…3 The clarithromycin drug is semi-synthetic macrolide antibiotic used to treat a variety of bacterial infections and extensively engaged in usual abolition treatment of gastric H. pylori infection and upper respiratory tract infections by preventing the bacteria by reducing the protein synthesis. 4,5 The drug has short half-life of 3-4 h, which requires frequent administration with normal conventional dosage form causing large and undesirable fluctuations in plasma concentration and this shortens duration of action for providing adequate treatment. Henceforth this necessitates the formulation of ER of semisynthetic macrolide antibiotic that can be administered once or twice daily that can maintain therapeutic range of the drug.…”

Section: Introductionmentioning

confidence: 99%

Central Composite Design Aided Formulation Development and Optimization of Clarythromycin Extended-Release Tablets

Chinthaginjala¹,

Ahad²,

Bhargav³

et al. 2021

IJPER

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Objectives:The present work was designed to formulate extended-release tablets of clarithromycin by means of central composite design. To assess the systematic considerate of input and output variables and to construct design space, the central composited design was used. Methods: The concentrations of tamarind kernel powder (X 1 ), ethyl cellulose (X 2 ) and polyvinyl pyrrolidone (X 3 ) remained as independent variables and responses were drug release in 2 h, 8 h and t50%. Polynomial equations were employed to forecast the quantitative result of nondependent constraints at different levels on responses. The model stood nonlinear and the curvature outcome was significant.Henceforth the study employed central composite design for optimization. Wet granulation method was used to prepare the tablets and were evaluated for pharmacotechnical properties. Results: FTIR and DSC studies signposted that drug and excipients were compatible. Precompression constraints specified respectable flow properties. The in vitro drug release of entire formulations at the end of 12 h was found to be 96.14% -98.23%. Increase in the concentration of tamarind kernel powder, ethyl cellulose decreased percentage drug release. Contour plots were utilized to assess the relationship between independent variables and dependent variables. Conclusion: The statistical model is scientifically effective as the investigational estimates and foreseen estimates proposed by the model were relatively close to each other. The outcomes confirmed the success of the anticipated design for development of clarithromycin extended-release tablets with optimized properties.

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Short-course versus long-course therapy of the same antibiotic for community-acquired pneumonia in adolescent and adult outpatients

López‐Alcalde

Rodríguez-Barrientos

Redondo-Sánchez³

et al. 2018

Cochrane Database of Systematic Reviews

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Clarithromycin Extended-Release Tablet

Cited by 23 publications

References 101 publications

Formulation and evaluation of floating bilayer tablet of Aceclofenac and Esomeprazole

Formulation and evaluation of floating bilayer tablet of Aceclofenac and Esomeprazole

Central Composite Design Aided Formulation Development and Optimization of Clarythromycin Extended-Release Tablets

Short-course versus long-course therapy of the same antibiotic for community-acquired pneumonia in adolescent and adult outpatients

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