“Clark/dysplastic” nevi with florid fibroplasia associated with pseudomelanomatous features

Ko, Christine J.; Bolognia, Jean L.; Glusac, Earl J.

doi:10.1016/j.jaad.2010.02.046

Cited by 20 publications

(34 citation statements)

References 20 publications

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“…11 Although it may be argued whether Clark nevus as described by Ackerman and Milde was meant to be synonymous with dysplastic nevus, the term has since been widely adopted as a synonym. [12][13][14][15][16][17] Because the term ''Clark nevus'' is still used by some to refer to any nevus with a shoulder, and by others as a synonym for dysplastic nevus, it continues to be a source of confusion. Our practice is moving away from the term in favor of the term ''atypical nevus.…”

Section: Atypical Nevus/dysplastic Nevusmentioning

confidence: 99%

Practical advice regarding problematic pigmented lesions

Elston

2012

Journal of the American Academy of Dermatology

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Section: Atypical Nevus/dysplastic Nevusmentioning

confidence: 99%

Practical advice regarding problematic pigmented lesions

Elston

2012

Journal of the American Academy of Dermatology

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“…Sclerosing nevus with pseudomelanomatous features (SNPFs; syn . nevus with florid fibroplasia, nevus with regression‐like fibrosis, non‐surgically traumatized nevus) is a melanocytic nevus commonly excised to rule out melanoma. SNPF is indeed recognized as a distinct clinical and pathologic entity that can closely simulate regressing melanoma.…”

Section: Introductionmentioning

confidence: 99%

“…This anatomical site is exposed to imperceptible microtrauma or inflammatory changes as the chronic friction of clothing, sunburn, seborrhoeic eczema or acne. However, some authors postulated that this type of fibrosis might be something intrinsic to the maturation process of a dysplastic nevus …”

Section: Introductionmentioning

confidence: 99%

Sclerosing nevus with pseudomelanomatous features: dermoscopic and confocal aspects

Bombonato

Pampena

Franceschini

et al. 2018

Acad Dermatol Venereol

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Background Sclerosing nevus with pseudomelanomatous features (SNPFs) is a clinical and pathologic entity that mimics melanoma both clinically and histologically. The lesion is a melanocytic nevus, histologically characterized by fibrosis and a pseudomelanomatous proliferation. It is typically seen in young to middle‐aged individuals, mainly on the back, where microtrauma or inflammatory changes are more frequent. Dermoscopic description of SNPF has been reported so far in one case series. Objective The aim of our study was to describe the dermoscopic and confocal features of SNPF. Methods Histopathologically confirmed cases of SNPF were retrospectively collected from three referral centres in Italy. Only lesions with available clinical, dermoscopic and histopathological data were included; confocal images were also retrieved, when available. Lesions were evaluated for the presence of 12 dermoscopic and five confocal criteria previously described. Results The study population included 93 lesions in as many patients (71 men and 22 women; median age: 38 years). Dermoscopically, we found a predominance of dark colours, in particular brown and blue, which were found in all lesions and the vast majority of the lesions (86/93; 92.5%) displayed at least one structureless area. By the combination of colours and structures, we observed that the majority of the lesions (67/92; 72%) were characterized by more than one structure and more than one colour. Confocal evaluation was performed on a subset of 24/93 lesions showing a regular architecture pattern (19/24 cases, 79%), with a predominance of the ringed pattern. The presence of focal cytologic atypia at the dermal‐epidermal junction was present in 12/24 cases (50%) with a prevalent dendritic‐shaped cell proliferation. Conclusions The current study demonstrated that SNPF was frequently characterized, on dermoscopic examination, by more than one structure and more than one colour and on confocal microscopy by a regular ringed pattern with focal dendritic atypical cells.

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“…Compound dysplastic nevi with florid fibroplasia often present clinically on the backs of older men 3 and may have a ‘pseudomelanomatous’ appearance histopathologically 4 . We previously examined a series of 42 such nevi 5 with routine hematoxylin and eosin staining. These cases were typified by symmetrical ‘bookends’ of typical ‘Clark/dysplastic’ nevus flanking a central, trizonal area composed of an often atypical junctional component overlying the nested melanocytes in prominent fibroplasia.…”

mentioning

confidence: 99%

“…1A, B). 4,5 Sixteen of these cases had sufficient available tissue for elastin staining to be completed.…”

mentioning

confidence: 99%

Elastin staining of ‘Clark/dysplastic’ nevi with florid fibroplasia associated with pseudomelanomatous features

Ko¹,

Glusac

McNiff

2011

J Cutan Pathol

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“Clark/dysplastic” nevi with florid fibroplasia associated with pseudomelanomatous features

Cited by 20 publications

References 20 publications

Practical advice regarding problematic pigmented lesions

Practical advice regarding problematic pigmented lesions

Sclerosing nevus with pseudomelanomatous features: dermoscopic and confocal aspects

Elastin staining of ‘Clark/dysplastic’ nevi with florid fibroplasia associated with pseudomelanomatous features

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