Clary Sage Essential Oil and Its Effect on Human Mood and Pulse Rate: An in vivo Pilot Study

Abstract

Clary sage (Salvia sclarea) is a xerophytic biennial plant typical for the Mediterranean region. It is cultivated for its essential oil, which is widely used in the flavor and fragrance industry as well as in aromatherapy for its relaxing and immunomodulatory effect. In this pilot investigation, clary sage essential oil was analyzed by GC-MS as well as GC-FID and examined regarding its effects on pulse, blood pressure and mood in healthy human female and male subjects. Analysis of the used CSEO identified linalylacetat (61.3%) and linalool (22.1%) as main compounds. Sclareol was found at 0.3%. In the first experiment with 30 participants (with 15 female), CSEO, diluted in peanut oil, was administered to the left forearm, leading to an increase in pulse rate in women (peanut oil served as control). In men, pulse rate deceased over time (p = 0.013). In the second experiment (32 participants; 16 females) the oil was inhaled for 30 min (pure water as control). The observed decrease of pulse rate was significantly stronger in women than in men (p = 0.026). To evaluate the influence of the mode of application, a comparison of both experiments was performed showing a significant difference between sexes for the parameter of pulse rate (p = 0.034). Overall, the effects elicited by CSEO may depend on application method (inhaled/dermal) and sex (male/female).

Benefícios do uso do óleo essencial de Sálvia esclaréia em ginecologia e no ciclo gravídico puerperal: revisão integrativa

“…Biomarcadores aumentados na ansiedade, como nível de carboidrato, por exemplo, sofreram redução após 10 dias de inalação [24]. Foi constatada em outro estudo a redução da pulsação após inalação do óleo essencial de Sálvia esclaréia em mulheres, apesar de não terem sido observadas mudanças na pressão arterial nem no humor (com base nos questionários aplicados antes e após a intervenção) [10]. Com base nesses achados, percebe-se que o óleo essencial de Sálvia esclaréia pode ser útil para atenuar sintomas da ansiedade, o que pode auxiliar pessoas passando por momentos de ansiedade diversos, como durante o parto ou no pós-parto, durante o climatério, entre outros momentos.…”

“…Título/Autoria/Ano/País Resultados principais Tipo de estudo Clary sage essential oil and its effect on human mood and pulse rate: an in vivo pilot study. [10] 2020. Áustria.…”

Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

“…Effects of essential oil from S. sclarea on pulse, blood pressure and mood were analyzed on healthy female and male humans (Mitic et al, 2020). The pulse rate decreased more significantly in women than in men.…”

The role of immersive multi-sensory interior design environment in reducing students' generalized anxiety disorder

“…For instance, according to previous research, lavender has stress-relieving and pain-control impacts and may help prevent depression (Chioca et al, 2013;Nasiri et al, 2016;Zamanifar et al, 2020). Another recognized relaxing smell is Salvia Sclarea or clary sage, which studies indicated has an impact on relaxation by alleviating pain and blood pressure (Mitic et al, 2020;Yang et al, 2014;You et al, 2011).…”