Class I and class II MHC polymorphisms in Mexican patients with Behçet’s disease

Study on association between polymorphism of HLA‐DRB1 alleles and Behçet's disease

“…14 In Mexico, HLA-DRB1 alleles typing in 32 BD patients was carried out by PCR sequence-specific oligonucleotide (PCR-SSO) reverse dot blot hybridization, and a significant increased frequency of HLA-DRB1*01 as well as HLA-DRB1*13 in patients was reported. 15 In Saudi Arabia, 13 patients with BD were typed for HLA-DRB1, HLA-DQB1 and HLA-DPB1 alleles by the PCR-restriction fragment length polymorphism (PCR-RFLP) method, but no significant difference was observed in HLA class II between the patients and controls. 16 In the Italian population, a previous study performed in 32 BD patients showed an association of II class antigen DRw52 with BD using serological method.…”

“…[2][3][4] Patients with this disease are scattered throughout the world but is most prevalent in countries from the Mediterranean region to Japan, along the ancient 'Silk Road'. 5,6 Although the main pathology of BD has been known to be the underlying vasculitis, the exact aetiology is still uncertain but is presumed to be multifactorial, implicating genetic predisposition, immune system dysregulation, infectious agents and some external environmental factors. 7,8 The strongest evidence of genetic susceptibility of BD is its association with a particular human leucocyte antigen (HLA) class I gene, HLA-B51.…”

“…4 In an attempt to find the association of HLA class II gene with BD, a number of studies have been performed in different ethnic groups, but the results varied with different countries and regions. [14][15][16][17][18][19][20] In a previous study, association of HLA class II with Chinese BD has been analysed grossly by serological method. 20 Recently, the new HLA genotyping method named LABType TM SSO was developed and has enabled us to rapidly detect and type the HLA-DRB1 alleles with an accurate probability of greater than 99.9% and without ambiguities.…”

Behçet’s disease and genes within the major histocompatibility complex region

“…A number of studies have investigated the association between HLA class II genes and BD in various ethnic groups [43,44,[63][64][65][66][67][68][69], but these have reported different results. Although a few studies have claimed to have found a significant association between HLA class II alleles and BD [44,[63][64][65], only a small number of patients were enrolled in these studies, and no allele was consistently identified.…”

“…Although a few studies have claimed to have found a significant association between HLA class II alleles and BD [44,[63][64][65], only a small number of patients were enrolled in these studies, and no allele was consistently identified.…”