Class-specific circulating antibodies in infections with Eimeria tenella

Trees, A. J.; Crozier, S.J.; McKellar, Susan; Wachira, Timothy

doi:10.1016/0304-4017(85)90069-x

Cited by 16 publications

(6 citation statements)

References 11 publications

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“…produce parasite-specific antibodies in both the circulation and mucosal secretions (36,56,74,91). Circulating antibodies consist of IgM, IgG, and IgA (66,107), whereas secretory IgA was detected in bile and gut washings of infected animals (66,91). In mice, IgA ϩ and IgG ϩ B cells were increased in number in intestinal sections taken following E. falciformis infection (74).…”

Section: Host Immune Responsesmentioning

confidence: 99%

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Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites

Lillehoj¹,

Trout²

1996

Clin Microbiol Rev

294

144

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Coccidiosis, an intestinal infection caused by intracellular protozoan parasites belonging to several different species of Eimeria, seriously impairs the growth and feed utilization of livestock and poultry. Host immune responses to coccidial infection are complex. Animals infected with Eimeria spp. produce parasite-specific antibodies in both the circulation and mucosal secretions. However, it appears that antibody-mediated responses play a minor role in protection against coccidiosis. Furthermore, there is increasing evidence that cell-mediated immunity plays a major role in resistance to infection. T lymphocytes appear to respond to coccidial infection through both cytokine production and a direct cytotoxic attack on infected cells. The exact mechanisms by which T cells eliminate the parasites, however, remain unclear. Although limited information is available on the intestinal immune system of chickens, gut lymphoid tissues have evolved specialized features that reflect their role as the first line of defense at mucosal surfaces, including both immunoregulatory cells and effector cells. This review summarizes our current understanding of the avian intestinal immune system and mucosal immune responses to Eimeria spp., providing an overview of the complex cellular and molecular events involved in intestinal immune responses to enteric pathogens.

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Section: Host Immune Responsesmentioning

confidence: 99%

“…The serum IgM response peaked at 17 days p.i. for infection with E. tenella (107) and at 10 to 20 days p.i. with E. nieschulzi in rats (91).…”

Section: Host Immune Responsesmentioning

confidence: 99%

Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites

Lillehoj¹,

Trout²

1996

Clin Microbiol Rev

294

144

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“…Serum IgM peaked 13 to 17 dpi of E. tenella (Trees et al, 1985) and at 10 dpi of E. nieschulzi infection (Rose et al, 1984a). Serum IgG titres peaked 13 to 17 dpi E. tenella (Trees et al, 1985), 20 to 30 dpi E. nieschulzi (Rose et al, 1984a), and 10 to 20 dpi E. bovis infection (Hughes et al, 1989).…”

Section: Systemic Responses To Coccidiamentioning

confidence: 99%

“…Isotypes of anti-coccidia antibodies in both the circulation and mucosal secretions have been studied (Rose et al, 1984a;Trees et al, 1985;Lillehoj, 1987b;Hughes et al, 1989). Serum IgM peaked 13 to 17 dpi of E. tenella (Trees et al, 1985) and at 10 dpi of E. nieschulzi infection (Rose et al, 1984a).…”

Section: Systemic Responses To Coccidiamentioning

confidence: 99%

Coccidia: A review of recent advances on immunity and vaccine development

1993

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“…Following E. tenella infection, the first class of antibodies that appears is of type IgM at 7-14 days post-infection in the caeca, followed by IgA and IgM [42,43]. After secondary infection, IgM antibodies in the caeca were observed at 3 weeks [44].…”

Section: Evolution Of Igm In Chicken Coccidiosismentioning

confidence: 99%

Passive immunity in poultry coccidiosis.

Cozma¹,

Titilincu²

2007

CABI Reviews

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Coccidiosis is a protozoosis causing important economic losses in poultry industry throughout the world, either due to mortality or to weight losses. The species belonging to the Eimeria genus are host-specific, and the resulting immunity is species-specific. The immune response to coccidiosis is primarily cellularly mediated and secondarily humorally mediated, by means of antibodies. Within the cellular immune response, the CD4 + and CD8 + cells, and the cytokines they secrete, play an important role. Nevertheless, it seems that in the first days of life, chicks are protected against infection by maternal antibodies, transferred via egg yolk. This type of immune protection is well known in the case of the Gumboro disease. Research over the past 16 years has shown that the immunoglobulin Y (IgY) transferred via the egg yolk to the chicks prevents the appearance of clinical coccidiosis in chicks. The production of specific antibodies in breeders can be stimulated through infections or immunization. It has also been demonstrated that the maternal antibodies that appear as a result of an infection with Eimeria spp. (Eimeria maxima) offer the chicks partial protection against infection with another species (Eimeria tenella), owing to the fact that some eimerian proteins seem to be common to more species.

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Class-specific circulating antibodies in infections with Eimeria tenella

Cited by 16 publications

References 11 publications

Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites

Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites

Coccidia: A review of recent advances on immunity and vaccine development

Passive immunity in poultry coccidiosis.

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