Class Specific Influence of Dietary Spirulina platensis on Antibody Production in Mice.

Phycocyanin Enhances Secretary IgA Antibody Response and Suppresses Allergic IgE Antibody Response in Mice Immunized with Antigen-Entrapped Biodegradable Microparticles

“…In the previous papers, we reported that neither Spi rulina-extract nor phycocyanin ingestion for 5wk affected IgE antibody response in C3H/HeJ mice, while IgA response in the mucosa was enhanced significantly (5,9). In the present study for both C3H/HeN and BALB/cA mice, serum OVA-specific IgE, as well as OVA specific IgGl antibody response to phycocyanin was not affected by a 6wk treatment with phycocyanin.…”

“…Oral intake of Spirulina controls blood sugar levels and improves hyperlipidemia and anemia (2,4), Ingestion of either intact or a hot water extract of Spirulina promotes phagocytic capacity of macro phages, production of interleukin-1, and both cell growth and antibody production in the spleen of mice (5,6). Moreover, calcium spirulan, one of the compo nents of the hot water extract of Spirulina, can inhibit virus entry (7) and metastasis of melanoma cells to the lung (8).…”

Effects of spirulina on the number of ovary mast cells in lead‐induced toxicity in rats

“…Spirulina platensis acts as an immunostimulator (Mosulishvili et al, 2004) and has demonstrated anticarcinogenic (Mathew et al, 1995;Mishima et al, 1998) and antiviral effects (Ayehunie et al, 1998). In addition, certain Spirulina subspecies affect the immune system by enhancing phagocytic activity in macrophages (Jassby, 1988) and inhibiting allergic reactions in rodents (Hayashi et al, 1998).…”

Proliferation and Differentiation of Hematopoietic Cells and Preservation of Immune Functions

“…We have reported that Spirulina and its extracts enhanced immune responses in mice, mainly through increased production of interleukin-1 (IL-1) in macrophages (Hayashi et al, 1994;Hayashi et al, 1998). In the mice which ingested phycocyanin for 6 weeks, a marked increase of OVA antigen-specific IgA, as well as total IgA level was observed in the Peyer's patches, mesenteric lymph nodes and intestinal mucosa, as well as in the spleen cells (Nemoto-Kawamura et al, 2004).…”