Classic fever of unknown origin: Analysis of a cohort of 87 patients according to the definition with qualitative study criterion

Diagnostic value of F-18 FDG PET/CT in fever or inflammation of unknown origin in a large single-center retrospective study

“…However, a 2015 pilot study identified F-18 FDG PET/CT as a cost-effective imaging routine in reducing the costs of further procedure and duration of hospitalization (€12,614 compared to €5,298 per FUO patient in the Netherlands) 35 . These findings were backed up by prospective observational study by Cachot et al 36 in 2021. Our study confirms these findings despite an unselected study population.…”

Prospective Studies Comparing Structured vs Nonstructured Diagnostic Protocol Evaluations Among Patients With Fever of Unknown Origin

“…Undiagnosed cases were reported in all but 2 studies 27 , 29 and ranged from 6.9% to 50.7%. Nine studies 1 , 2 , 6 , 15 , 16 , 17 , 18 , 19 , 29 , 30 with 1228 of the 2627 total participants (46.7%) used the criteria of Peterdorf and Beeson 4 to classify FUO, and 7 studies 21 , 22 , 24 , 26 , 27 , 28 , 31 combining 1135 participants (43.2%) were classified by the criteria of Durack and Street. 5 Three studies 20 , 23 , 25 of 264 participants (10.0%) were classified by either the Petersdorf and Beeson 4 or Durack and Street 5 criteria.…”

“…Applying an agglomerative hierarchical clustering algorithm to outcomes data of these 17 prospective studies yielded a dendrogram (eFigure 5 in the Supplement ). The WHO region for European studies was divided into 2 categories: EUR2 (Turkey 15 , 17 , 19 , 20 , 21 plus Romania 17 ) and EUR1 (all other European studies 1 , 2 , 6 , 18 , 26 , 31 ). There were many studies in the EUR1 region with far more substantial similarities in diagnostic outcomes.…”

“…The statistical adjustment for potential confounding factors is limited by the number of published, prospective studies and the completeness and consistency of their reporting. Only 4 trials, 2 using structured protocols 1 , 2 , 6 and 2 using nonstructured protocols, 28 , 31 reported some data regarding the contribution of potential diagnostic clues, making for insufficient comparison. Other variables may explain the considerable variation between studies in the same region, hospital system, or facility.…”

“…The search produced 19 prospective studies 1,2,6,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] (including 2 references for the study by de Kleijn et al 1,2 ) meeting the inclusion criteria (Figure 1). Each study's characteristics and diagnostic yield were considered individually (Table 1).…”