I would like to express my appreciation to all the people who have helped me in my 3 years of PhD research. Thanks to Mr Chandrasekar from LTA for providing the accident data. Thanks to the committee members, Assoc Prof Wang Zhiwei, David, and Asst Prof Liu Fang, for their insightful suggestions. Thanks to those anonymous reviewers whose comments lead to a big improvement in my research papers. Many thanks also go to my fellow PhD students and colleagues in the Centre for Infrastructure Systems, for friendship and collaboration. I am most grateful to the NGSIM Program for the availability of data, and to the contributors in the fields of machine learning and Python, among others. My deepest gratitude is to my wife, Dr. Chai, and our beloved parents and son, thanks for your brilliant support and love in my life. vi