2009
DOI: 10.1159/000189200
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Classification of Hypersensitivity Pneumonitis

Abstract: Background: Regardless of the causative antigen, hypersensitivity pneumonitis (HP) is usually classified as ‘acute’, ‘subacute’ or ‘chronic’. Considerable confusion still surrounds this classification because there are no widely accepted criteria to distinguish the various stages. The objective of this study wasto determine whether the current classification of HP truly reflects categories of patients with distinct clinical features. Methods: Data obtained from a large prospective multicenter cohort study (the… Show more

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Cited by 159 publications
(100 citation statements)
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“…Although there was environmental exposure in these cases, inhalation of the antigens was not as massive as in the other patients. It is reasonable that high-intensity exposure to the causative antigen would trigger acute forms (25), whereas low-grade, prolonged exposure would be associated with a subacute or chronic presentation. In this line, it is worthy of note that in cases 4 and 5 the latency period between the start of exposure and the development of symptoms was long, whereas in patients 1 and 2, it was a matter of days.…”
Section: Discussionmentioning
confidence: 99%
“…Although there was environmental exposure in these cases, inhalation of the antigens was not as massive as in the other patients. It is reasonable that high-intensity exposure to the causative antigen would trigger acute forms (25), whereas low-grade, prolonged exposure would be associated with a subacute or chronic presentation. In this line, it is worthy of note that in cases 4 and 5 the latency period between the start of exposure and the development of symptoms was long, whereas in patients 1 and 2, it was a matter of days.…”
Section: Discussionmentioning
confidence: 99%
“…ÔacuteÕ, ÔsubacuteÕ or ÔchronicÕ) truly reflects categories of patients with distinct clinical features (34). Data were used to divide a cohort of patients with HP into a limited number of categories (ÔclustersÕ) with maximally differing clinical patterns, without prejudgement.…”
Section: Classification Of Hpmentioning
confidence: 99%
“…HP is classified as acute or chronic 2, 3. According to a national survey in Japan, avian antigen is the cause of chronic HP in 61% of cases 4.…”
Section: Introductionmentioning
confidence: 99%