Classification of Renal Proliferative Lesions in Rats and/or Mice and Their Diagnostic Problems: Report from the Working Group of the Japanese Society of Toxicologic Pathology.

Mitsumori, Kunitoshi; Yoshida, Midori; Iwata, Hijiri; Katsuda, Osamu; Kouchi, Mami; Tsuda, Hiroyuki

doi:10.1293/tox.15.175

Cited by 10 publications

(18 citation statements)

References 12 publications

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“…at UNIV CALIFORNIA SANTA BARBARA on June 22, 2015 tpx.sagepub.com Downloaded from Differential diagnoses Atypical tubule hyperplasia: Proliferation does not exceed integrity of a single tubule; usually less than 6 contiguous profiles of proliferation representing convolutions of a single tubule; vascular ingrowth absent (Bannasch and Ahn 1998b;Dietrich and Swenberg, 1991;Hard 1990;Mitsumori et al 2002) Carcinoma: Larger than a few millimeters; evidence of cell and/or nuclear pleomorphism, multiple areas of necrosis or hemorrhage; usually conspicuous mitotic activity; invasion or metastasis may be present (Hard 1984;Alden et al 1992;Hard et al 2001a) Regenerative tubules in CPN: Bland cells and nuclei; no vascular ingrowth; often surrounded by thickened basement membrane with no margination of fibroblasts (Hard and Seely 2005) Oncocytoma: clusters of large, lightly eosinophilic, granular cells usually without glandular formation Comment: There is neoplastic progression of proliferative responses from atypical tubule hyperplasia through to adenoma and carcinoma (Dietrich and Swenberg 1991). Basophilic adenomas of lobular organization are by far the most common type in rats and mice.…”

Section: Proliferative Lesions: Neoplasiamentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

et al. 2012

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The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying lesions observed in the urinary tract of rats and mice. The standardized nomenclature of urinary tract lesions presented in this document is also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous developmental and aging lesions as well as those induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for urinary tract lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Section: Proliferative Lesions: Neoplasiamentioning

confidence: 99%

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

et al. 2012

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“…Rat RMTs originated from foci of atypical fibroblast-like cells in the interstitium of the outer stripe of the outer medulla, similar to congenital mesoblastic nephromas in human infants 18 , 19 . The rat RMTs are characterized by a heterogeneous connective tissue cell composition with a predominance of spindle cells with a primitive mesenchyme and smooth muscle fibers and occasional rhabdomyoblasts, striated muscle, cartilage and osteoid or hemangiosarcomatous areas 16 , 20 . Nephroblastoma in rats, equivalent to Wilms tumor in human nomenclature, originates from the metanephric blastema.…”

Section: Methodsmentioning

confidence: 99%

“…Nephroblastoma in rats, equivalent to Wilms tumor in human nomenclature, originates from the metanephric blastema. It is characterized by discrete clusters of highly basophilic blast cells surrounding mature ducts and organoid differentiation as epithelial rosettes, primitive basophilic tubules, attempted glomerulus formation, or mature epithelial ducts 16 , 20 .…”

Section: Methodsmentioning

confidence: 99%

<i>N</i>-Methyl-<i>N </i>-nitrosourea-induced Renal Tumors in Rats: Immunohistochemical Comparison to Human Wilms Tumors

et al. 2013

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N-Methyl-N-nitrosourea (MNU)-induced renal tumors in rats and Wilms tumors in humans were compared. Renal mesenchymal tumors (RMTs) and nephroblastomas (blastemal and epithelial components) in female Lewis rats treated with a single intraperitoneal injection of 50 mg/kg MNU at birth and Wilms tumors (blastemal, epithelial and mesenchymal components) in humans were analyzed for the expression of pancytokeratin (CK), vimentin, p63, α-smooth muscle actin (SMA), desmin, S-100, CD57, CD117/c-kit, Wilms tumor 1 protein (WT1) and β-catenin. The mesenchymal components of rat RMTs and human Wilms tumors expressed vimentin, SMA and β-catenin. The blastemal components of rat nephroblastomas and human Wilms tumors expressed vimentin, CD117/c-kit and β-catenin. The epithelial components of rat nephroblastomas and human Wilms tumors expressed vimentin and β-catenin. WT1 was expressed in different cellular components of rat tumors as compared with human Wilms tumors; the expression was seen in mesenchymal tumors and blastemal components of nephroblastomas in rats and epithelial components in human Wilms tumors. CK, p63 and CD57 were not expressed in rat RMTs or nephroblastomas, while CK and WT1 were expressed in epithelial components and CD57 was expressed in blastemal and epithelial components of human Wilms tumors. Rat and human tumors were universally negative for the expression of desmin and S-100. The immunohistochemical characteristics of rat renal tumors and human Wilms tumors may provide valuable information on the differences in renal oncogenesis and biology between the two species.

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“…Nephroblastoma, known as Wilms' tumor in humans, originates from the metanephric blastema. It is characterized by discrete clusters of highly basophilic blast cells surrounding mature ducts and organoid differentiation as epithelial rosettes, primitive basophilic tubules, attempted glomerulus formation or mature epithelial ducts (20,21). Nephroblastomatosis is a small, solitary, basophilic cell mass consisting of densely crowded blast cells with ill-defined cytoplasm and basophilic nuclei and a few signs of early organoid differentiation into epithelial rosettes (20,22,23).…”

Section: Methodsmentioning

confidence: 99%

“…Mesenchymal tumors originate from foci of atypical fibroblast-like cells in the interstitium of the outer stripe of outer medulla, similar to a renal tumor of infancy described as congenital mesoblastic nephroma (22,25,26). Mesenchymal tumors are characterized by heterogeneous connective tissue cell composition with a predominance of spindle cells, primitive mesenchyme, and smooth muscle fibers and occasional rhabdomyoblasts, striated muscle, cartilage, osteoid or hemangiosarcoma-like areas (20,21). Renal mesenchymal tumors are frequently misdiagnosed as nephroblastomas due to the pre-existing tubules that survive within the tumor tissue and which can become hyperplastic and/or metaplastic (9,24).…”

Section: Methodsmentioning

confidence: 99%

Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats

et al. 2013

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Arachidonic acid (AA) is naturally found in human breast milk. AA, together with docosahexaenoic acid, is commonly added as a functional food ingredient to commercial infant formula worldwide, in accordance with the international standards of Codex Alimentarius. However, few studies of the possible renal carcinogenic effects of AA supplementation during neonatal life have been performed. The effect of dietary AA supplementation in dams during gestation and lactation was investigated on N-methyl-N-nitrosourea (MNU)-induced preneoplastic lesions in the kidneys of young Lewis rats. Dams were fed a 2.0% AA diet or a basal diet (<0.01% AA). At birth (postnatal day 0), male and female pups received a single intraperitoneal injection of 35 mg/kg MNU or vehicle. Renal morphology was examined after 7, 14, 21, 28 and 60 days. Histopathologically, renal preneoplastic lesions, such as nephroblastomatosis and mesenchymal cell proliferation, were found on day 60 in both the MNU-treated groups. There was no significant difference in lesion incidence of 38% in the basal diet group and 31% in the AA diet group. In conclusion, an AA-rich diet for dams during gestation and lactation does not modify MNU-induced renal preneoplastic lesions in their offspring.

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Classification of Renal Proliferative Lesions in Rats and/or Mice and Their Diagnostic Problems: Report from the Working Group of the Japanese Society of Toxicologic Pathology.

Abstract: The Working Group for the Proliferative Lesions of the Kidney in Rats and [175][176][177][178][179][180][181][182][183][184][185][186][187][188][189][190]

Cited by 10 publications

References 12 publications

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System

<i>N</i>-Methyl-<i>N </i>-nitrosourea-induced Renal Tumors in Rats: Immunohistochemical Comparison to Human Wilms Tumors

Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal preneoplastic lesions in young Lewis rats

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