Classification Perfection of Acute Kidney Injury and Chronic Kidney Diease in Рediatric Nephrology

Савенкова, Н. Д.

doi:10.24884/1561-6274-2018-22-3-11-17

Nefrologiâ (St.-Peterbg.)

2018

DOI: 10.24884/1561-6274-2018-22-3-11-17

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Classification Perfection of Acute Kidney Injury and Chronic Kidney Diease in Рediatric Nephrology

Н. Д. Савенкова¹

Abstract: РЕФЕРАТ В статье приведены педиатрические классификации острого повреждения почек и хронической болезни почек у детей, нерешенные проблемы. Ключевые слова: острое повреждение почек, хроническая болезнь почек, дети, проблемы ABSTRACT In article presentation features of classification systems acute kidney injury and chronic kidney diease in children, unsolved problems.

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Cited by 4 publications

References 8 publications

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Prediction of cardiovascular complications and progression of renal failure in pediatric patients with chronic kidney disease according to NKF-K/DOQI (2002) and KDIGO (2012) classifications

Савенкова

Григорьева

2022

Ross. vestn. perinatol. pediatr.

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Chronic kidney disease in pediatric and adult patients is an overarching global problem. Stratification of chronic kidney disease C1–5 severity by classifications of the National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI) (2002) and Kidney Disease: Improving Global Outcomes (KDIGO) (2012) carried out in pediatric patients over the age of 2 years old, taking into account the low glomerular filtration rate at the age of 0 to 2 years. Differences were found in the prognosis of cardiovascular complications and the progression of renal failure in adult patients with chronic kidney disease at stages С3а and C3b according to KDIGO (2012). The literature data demonstrate different risks of cardiovascular complications and progression of renal functions by stages of chronic kidney disease in accordance with the NKF-K/DOQI (2002) and KDIGO (2012) classifications in pediatric patients. The results indicate that children with chronic kidney disease in the pre-dialysis stages C2–4 form a high-risk group, while those on C4–5 dialysis form a group of very high risk of cardiovascular complications.

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Prediction of cardiovascular complications and progression of renal failure in pediatric patients with chronic kidney disease according to NKF-K/DOQI (2002) and KDIGO (2012) classifications

Савенкова

Григорьева

2022

Ross. vestn. perinatol. pediatr.

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Chronic kidney disease in children

Vyalkova

Зорин

Chesnokova

et al. 2019

Nefrologiâ (St.-Peterbg.)

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The goal is to discuss the criteria for the early diagnosis of chronic kidney disease (CKD) in children. The article presents data from modern literature on the epidemiology, classification, and criteria for the diagnosis of CKD, own scientific results on clinical and paraclinical characteristics of CKD and regional characteristics of CKD in children of the Orenburg region. Modern approaches to the early diagnosis of CKD in children, the identification of risk factors for the progression of nephropathy and the algorithm for the diagnosis of CKD in childhood, taking into account unfavorable regional factors, are scientifically substantiated. A set of measures for the prevention of nephropathy and a scheme of follow-up observation of children at high risk has been developed. The ways to improve the children's nephrology service are substantiated. Modern pathogenetic approaches to the diagnosis of CKD in children are presented. An algorithm for diagnosing the initial stages of CKD in children at risk for CKD and children with renal pathology without CKD with a preliminary selection of anamnestic and clinical and paraclinical indicators is proposed.

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Outcomes of hemolytic-uremic syndrome in children

Gunkova,

Vyalkova,

Chesnokova

et al. 2024

General Physician

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It is proved that HUS in children is the cause of the formation and progression of renal dysfunction with the formation of CKD. At the same time, the outcomes of HUS in childhood remain insufficiently studied. Purpose. To establish the outcomes of hemolytic-uremic syndrome in children and to develop an algorithm for their prediction.Results. Seasonality is established (May and June) HUS in children, an increase in the incidence rate. In the structure of HUS in children of the Orenburg region, STEC-HUS prevails (96.5 %), more often (68.6 %) in infants and young children. Chronic kidney diseases associated with HUS are characterized by a violation of the structure of the kidneys, a decrease in intrarenal hemodynamics, increased blood pressure, microalbuminuria, tubular dysfunction and a decrease in glomerular filtration rate in combination with an increase in the level of endothelin-1 blood, cystatin From urine and blood, uNGAL. An increase in endothelin-1 in blood, cystatin From urine and blood, uNGAL correlates with the level of increased blood pressure, a decrease in intrarenal hemodynamics, GFR and tubular dysfunction and are pathogenetic criteria for kidney damage in HUS convalescent children. Discussion. Clinical and pathogenetic markers of the formation of CKD have been established: an increase in the level of blood EТ-1, blood cystatin, urine lipocalin in combination with arterial hypertension, a decrease in GFR and intrarenal hemodynamics, an increase in tubular dysfunction and the level of microalbuminuria. Conclusion. The outcomes of HUS in children are- favorable (recovery); unfavorable (formation of chronic kidney pathology): TIBP, occurring with isolated urinary syndrome; nephropathies with isolated prenephrotic proteinuria; chronic kidney disease; fatal outcome. The developed «Algorithm for predicting chronic kidney damage in children with HUS convalescents», «Method for predicting tubulo-interstitial kidney disease in children associated with hemolytic-uremic syndrome», allow optimizing the early diagnosis of chronic kidney pathology in children after HUS, contribute to the timely appointment of preventive measures to prevent the progression of renal dysfunction and is recommended for use in the practice of pediatricians, nephrologists.

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Classification Perfection of Acute Kidney Injury and Chronic Kidney Diease in Рediatric Nephrology

Cited by 4 publications

References 8 publications

Prediction of cardiovascular complications and progression of renal failure in pediatric patients with chronic kidney disease according to NKF-K/DOQI (2002) and KDIGO (2012) classifications

Prediction of cardiovascular complications and progression of renal failure in pediatric patients with chronic kidney disease according to NKF-K/DOQI (2002) and KDIGO (2012) classifications

Chronic kidney disease in children

Outcomes of hemolytic-uremic syndrome in children

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