Classifying Patients by Antipsychotic Adherence Patterns Using Latent Class Analysis: Characteristics of Nonadherent Groups in the California Medicaid (Medi-Cal) Program

Abstract

Multiple indicators of adherence to antipsychotic medication can be used to define classes of adherence that are associated with patient characteristics and distinct patterns of prior health-care use.

Long-Acting Injectable Antipsychotics: An Underutilized Treatment Option

“…In most Western countries, the prescription rate is below 10% of all antipsychotics. [2][3][4] This low rate is in contrast to evidence from naturalistic studies repeatedly demonstrating lower relapse and rehospitalization rates in patients receiving LAIs compared to oral treatment. [5][6][7] Although some colleagues might point out that recent randomized controlled trials (RCTs) [8][9][10] failed to corroborate results from the naturalistic studies, a broad consensus has developed that the patients in these RCTs (ie, those who are motivated to participate in a demanding clinical trial) are most likely not representative of those we see in our everyday clinical routine (ie, patients facing compliance problems).…”

Psychotropic Medication Adherence among Community-Based Individuals with Developmental Disabilities and Mental Illness

“…The rate of non-adherence to psychotropic drugs in our dual diagnosed target population was 25.7%, lower than the non-adherence rate in the general psychiatric population, which ranges from 39% to 64.5%, depending on the study population, setting, and method of assessment (Ahn et al, 2008;Gilmer et al, 2004;Rascati et al, 2011;Sajatovic, Valenstein, Blow, Ganoczy, & Ignacio, 2006;Stephenson et al, 2012). Wu, Erickson, Piette, and Balkrishnan (2012), who conducted a study of antidepressant adherence among Medicaid enrollees with major depressive disorder, found that the average MPRm rate [MPRm = Number of days supply/(last claim date − index date + last days' supply)] was about 0.72 in those with comorbid anxiety.…”

Development and Delivery of a Quality Improvement Program to Reduce Antipsychotic Polytherapy

“…Results of analyses of side effects with polytherapy are mixed. 7,9,[11][12][13][14][15] Adherence is decreased with antipsychotic polytherapy, 16 and the additional medication costs associated with antipsychotic polytherapy do not appear to be offset by cost savings in other areas of treatment. 17 Despite these mixed data, the use of antipsychotic polytherapy is common.…”