Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation (Review)

Abstract

Tight junctions (TJs) are an important component of cell connectivity; they maintain cell polarity, permeability and adhesion, and participate in the regulation of cell proliferation and differentiation. The claudin (cldn) family is integral to TJs, and cldn6 is an important member of this family. abnormal expression of cldn6 can destroy the integrity of TJs through various mechanisms and can serve multiple roles in the occurrence and development of tumours. cldn6 is widely expressed in various tumours but rarely expressed in healthy adult tissues. The aim of this review is to critically examine the recent literature on cldn6, including its structure, expression in different tumours, regulatory mechanisms and therapeutic prospects. although some conclusions are controversial, in certain tumours, such as liver, ovarian, endometrial and oesophageal cancer, and atypical teratoid/rhabdoid tumours, research consistently shows that cldn6 is expressed in tumour tissues but is not expressed or is expressed at low levels in surrounding tissues. in these tumours, cldn6 has potential as a carcinoembryonic antigen and a therapeutic target. Contents1. introduction 2. Structural characteristics of cldn6 3. expression and regulation mechanisms of cldn6 in tumours 4. cldn6 and drug resistance in cancer 5. Prospect of cldn6 in the treatment of tumours 6. discussion conclusionHuan du 1,2 , XiYue YanG 2 , JinJia Fan 2 and XiaoBo du 1

CLDN6 Suppresses c–MYC–Mediated Aerobic Glycolysis to Inhibit Proliferation by TAZ in Breast Cancer

“…More than a simple static component that establishes the tight junction, CLDN6 is also a cellular signaling component that functions to receive environmental signals and transmit them intracellularly. It is relevant to multiple biological behaviors of tumors such as proliferation, apoptosis, autophagy, drug resistance, and metastasis [ 7 , 23 ]. CLDN6 is an ideal target for antibody approaches of high potency in cancers with high CLDN6 expression based on the fact that CLDN6 is undetectable in the adult tissues [ 24 , 25 , 26 ].…”

“…As a member of CLDNs, CLDN6 is involved in regulating epidermal barrier formation [ 3 , 4 , 5 ] and epithelial permeability [ 6 ]. In addition to the above canonical functions, dysregulated CLDN6 is related to neoplastic growth and aggressiveness in cancers [ 7 ]. We have reported that CLDN6 overexpression suppressed breast cancer metastasis by inhibiting EMT [ 8 ].…”

The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma

“…Overexpression of CLDN-3 and CLDN-4 is observed in EEC and may be involved in endometrial tumorgenesis [ 23 , 24 ]. CLDN-6 has potential as a carcinoembryonic antigen, is highly expressed in EEC, and promotes endometrial cancer progression [ 25 , 26 , 27 ].…”

Research progress on the mechanism of radiation enteritis

“…The tight junctions (TJs) between the intestinal epithelial cells (IECs) constitute the second barrier of the intestinal barrier ( 9 , 10 ), which are the determinant of the intestinal barrier function ( 5 ). The TJs’ structure is composed of transmembrane proteins such as claudin, occludin, tricellulin, and junction adhesion molecules ( 11 , 12 ). TJs connect IECs to form a continuous polarized single-layer structure, separating the lumen from the lamina propria ( 13 , 14 ).…”