Claudin and p53 expression in vulvar lichen sclerosus and squamous-cell carcinoma

Abstract

Claudin 7 and 11 were not expressed in LS and SCC. However, there was no significant difference in expression of any of the claudins between the LS and SCC samples. Furthermore, p53 expression is the highest in SCC patients and lowest in the control group. However, expression of p53 did not vary between samples from isolated LS and LS associated SCC patients, suggesting that increased p53 expression is not the determining factor in the progression of LS lesions to SCC.

Prognostication of Vulvar Cancer Based on p14ARF Status: Molecular Assessment of Transcript and Protein

“…[1][2][3][4] Two major pathways in vulvar carcinogenesis have been the target of a range of studies: the INK4-cyclin/ cdk-Rb and ARF-MDM2-p53 pathways. The role of the tumor-suppressor genes, p53, p16INK4a, and pRb, have been widely studied; however, p14 ARF , which also is an important suppressor gene that connects both previously cited pathways, is poorly investigated.…”

Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma

“…Recently, claudin 7 expression was found to be decreased in lichen sclerosus and vulvar carcinoma compared to normal controls [14]. Low claudin 7 expression and malignant progression was previously found in squamous cell carcinoma of the esophagus [29].…”

“…Among gynecological tumors, strong claudin expression has been shown in cervical cancer and cervical intraepithelial neoplasia [11], endometriod adenocarcinoma of the uterus [7] and ovarian carcinoma [12,13]. Claudins 1, 2, 3, 4 and 5 have been found to be expressed equally in vulvar carcinoma, lichen sclerosus and normal controls, whereas claudins 7 and 11 were decreased in lichen sclerosus and vulvar carcinoma [14]. This is the first study comparing claudin expression in vulvar intraepithelial neoplasia and invasive vulvar carcinoma.…”

Perfil de expressão de claudinas nas lesões de verruga plana e carcinomas cutâneos na epidermodisplasia verruciforme

“…O aumento da expressão da claudina-1 nos CEC bem diferenciados é seguido da sua redução, com a progressão da doença 12 . Aumento da claudina-1 também foi observado nos CEC de diversos órgãos, como língua, tonsila, nasofaringe, pulmão, ovário e vulva 23,143,[150][151][152] . Entretanto, as células neoplásicas do CEC tonsilar infectadas pelo HPV não alteraram a expressão das TJ 23 .…”

“…A sua diminuição de expressão está associada ao aumento da capacidade invasiva das células nos carcinomas gástricos e de bexiga 195,196 . A redução da expressão de claudina-11 é ainda descrita no câncer e vulva, no melanoma cutâneo, no CEC de laringe e no carcinoma colorretal 143,[197][198][199] . TMA 01 "espelho"…”